Hempleaf groundsel herb phenolic acid ingredient as well as preparation method and application thereof

A technology of rejuvenating phenolic acid and rejuvenating grass, which is applied in the field of biomedicine and can solve the problems of increased drug resistance, allergic reactions, secondary infections, etc.

Inactive Publication Date: 2018-10-12
吉林益民堂制药有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antibiotics such as azithromycin and cefofloxacin are mainly used for anti-inflammatory treatment in the clinical treatment of pulmonary infection. Long-term use will cause increased drug resistance and side effects such as allergic reactions, body flora imbalance, and secondary infection, breaking the body’s immune system. systemic and antioxidant system balance

Method used

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  • Hempleaf groundsel herb phenolic acid ingredient as well as preparation method and application thereof
  • Hempleaf groundsel herb phenolic acid ingredient as well as preparation method and application thereof
  • Hempleaf groundsel herb phenolic acid ingredient as well as preparation method and application thereof

Examples

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Embodiment Construction

[0029] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field, or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that can be purchased through formal channels.

[0030] The following experiments are used to further illustrate the invention.

[0031] 1. Extraction of fenugreek phenolic acid

[0032] Add water and decoct the Herb Resurrection Soul to obtain the decoction liquid, filter the decoction liquid with a membrane with a molecular weight cut-off of 5000-30000, then concentrate the filtrate into a thick paste by nanofiltration, and finally dry and pulverize the thick paste to obtain the Resurrection Soul Grass water ...

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Abstract

The invention provides a hempleaf groundsel herb phenolic acid ingredient as well as a preparation method and application thereof. The hempleaf groundsel herb phenolic acid ingredient is the ethanol washing part obtained by separating a hempleaf groundsel herb aqueous extract through D101 macroporous resin, and the total phenolic acid purity is 70.42-76.43%. The antioxidant, anti-inflammation andanti-bacterial capabilities of the hempleaf groundsel herb phenolic acid ingredient are evaluated through a chemical and biological method, and the result shows that the hempleaf groundsel herb phenolic acid ingredient has the outstanding treatment effect in a oxidative damage model of human bronchial epithelial cells. The hempleaf groundsel herb phenolic acid ingredient can be applied to treatment or auxiliary treatment of diversified human or animal bacteriosis, lung infection, cancers and various kinds of diseases such as systemic inflammation and oxidative stress caused by different reasons, and has the wide application prospects.

Description

technical field [0001] The invention relates to a rejuvenating phenolic acid component, and provides its application in the fields of anti-oxidation, anti-inflammation and antibacterial, and belongs to the field of biomedicine. Background technique [0002] Senecionis Cannabifolii Herba (SCH), also known as Qingwan, Ziqian, etc., is a perennial herb of the genus Senecion in the Asteraceae family. Flavonoids mainly include flavonoids, phenolic acids, alkaloids, volatile oils and trace elements. Among them, phenolic acids have biological functions such as anti-oxidation, anti-tumor, anti-inflammation and sterilization. It has been reported to have antiviral, antibacterial, anti-acute lung injury, anti-inflammatory, immune-regulating, antipyretic and anti-gastric ulcer activities, so it is widely used in the treatment of cough and asthma, acute inflammation of the lungs, and chronic inflammation. [0003] Fenhuncao granule is a unilateral preparation obtained from Fenhuncao gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P39/06A61P29/00A61P31/04
CPCA61K36/28A61K2236/331A61K2236/55A61P29/00A61P31/04A61P39/06
Inventor 纪圣君郭晶李艳茹金英贾东旭王春驰周婷婷赵昱伟高其品
Owner 吉林益民堂制药有限公司
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