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A kind of mulberry leaf extract and its preparation method, application and health wine

A mulberry leaf extract and mulberry leaf technology, applied in the field of extraction of plant components, can solve the problems of long process cycle, high production cost, and difficult promotion, and achieve the effects of high purity, low production cost and high yield

Active Publication Date: 2022-02-18
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the special structure of DNJ, there are not many methods suitable for separating DNJ. The main method is ion exchange. The specific extraction method is to heat and reflux to extract the crude extract of mulberry leaf water with more impurities, and then use macroporous resin to adsorb and remove flavonoids, Impurities such as polysaccharides are enriched and purified by ion exchange resins to prepare mulberry leaf DNJ, but this process has a long cycle and complicated process, is not easy to popularize, and has high production costs

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  • A kind of mulberry leaf extract and its preparation method, application and health wine

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preparation example Construction

[0029] see figure 1 Shown, the embodiment of the present invention provides a kind of preparation method of mulberry leaf extract, it comprises the following steps:

[0030] (1) Extraction: take mulberry leaf medicinal material and deionized water, the dosage ratio of mulberry leaf medicinal material and deionized water is 1g: 15-20mL, heat and reflux at 80-90°C for 2-3 times, 1-2 times each time hour, after coarse filtration with a 100-mesh filter screen, the combined filtrate was collected to obtain the crude extract of mulberry leaf water.

[0031] (2) Filtration: the crude mulberry leaf water extract is filtered, generally by a disc centrifuge to obtain a clarified mulberry leaf extract.

[0032] (3) Resin adsorption: Put the mulberry leaf extract on the cation exchange resin, the sample loading speed is generally 1-4BV / h, and after the sample loading is completed, let it stand for 1-3 hours for adsorption. Because the molecular structure of DNJ contains -NH, which exist...

Embodiment 1

[0046] This embodiment provides a kind of mulberry leaf extract, which is extracted by the following preparation method:

[0047] (1) Extraction: Take 100kg of mulberry leaf medicinal material, add water to extract twice, add water 1500L each time, extract at 80°C for 2 hours, filter through a 100-mesh filter, collect and combine the filtrates to obtain a crude mulberry leaf water extract.

[0048] (2) Filtration: filter the crude mulberry leaf water extract through a disc centrifuge to obtain a clarified mulberry leaf extract.

[0049] (3) Resin adsorption: Put the mulberry leaf extract on the 001*7 type cation (H type) exchange resin at a flow rate of 2BV / h, and then let it stand for 2 hours for adsorption after the sample loading is completed.

[0050] (4) Resin elution: After the adsorption is completed, first add 4 times the volume of the resin to elute with purified water, then add 5 times the volume of the resin and 0.25mol / L ammonia water for elution, and the elution r...

Embodiment 2

[0054] This embodiment provides a kind of mulberry leaf extract, which is extracted by the following preparation method:

[0055] (1) Extraction: Take 200kg of mulberry leaf medicinal material, add water to extract 3 times, add water 4000L each time, extract at 85°C for 1 hour, filter through a 100-mesh filter, collect and combine the filtrates to obtain a crude mulberry leaf water extract.

[0056] (2) Filtration: filter the crude mulberry leaf water extract through a disc centrifuge to obtain a clarified mulberry leaf extract.

[0057] (3) Resin adsorption: put the filtered mulberry leaf extract on the R120 type (Na type) cation exchange resin at a flow rate of 2BV / h, and let it stand for adsorption for 2 hours after the sample loading is completed.

[0058] (4) Resin elution: After the adsorption is completed, first add 4 times the volume of resin for elution with pure water, then add 4 times the volume of resin and 0.30mol / L ammonia water for elution, and the elution rate ...

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Abstract

A mulberry leaf extract, its preparation method, application and health wine, relate to the field of extraction of plant components. The preparation method of the mulberry leaf extract in the embodiment of the present invention is to filter the crude mulberry leaf water extract to obtain the mulberry leaf extract; apply the mulberry leaf extract to a cation exchange resin, and then let the mulberry leaf extract stand for adsorption for 1 to 3 hours; first add pure water to elute, then add ammonia to elute to obtain the ammonia eluate; the ammonia eluate is concentrated and dried to obtain the mulberry leaf extract. The preparation method has simple process, low production cost, and DNJ purity High, high yield, suitable for industrialized large-scale production; DNJ purity is high in the mulberry leaf extract of the embodiment of the present invention; the application of the other mulberry leaf extract of the embodiment of the present invention is for preparing health wine; the embodiment of the present invention Health wine contains a lot of effective functional ingredients DNJ.

Description

technical field [0001] The invention relates to the field of extraction of plant components, and in particular to a mulberry leaf extract, its preparation method, application and health wine. Background technique [0002] Mulberry leaves, also known as iron fan, are leaves of Moraceae Morus alba L., native to China and Korea, and distributed in tropical Asia, tropical Africa, north temperate zone and America. Mulberry leaves are rich in nutrition, contain a variety of active ingredients, and have the characteristics of mild medicinal properties and no side effects. Mulberry leaves contain a variety of effective functional ingredients, such as amino acids, proteins, polysaccharides, flavonoids, alkaloids, phytosterols, isoquercetin glycosides, multivitamins and trace elements. Our country is rich in mulberry leaf resources, with a variety of varieties and a wide distribution area, but the utilization rate is low. Except for silkworm rearing, most of them are withered and ro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605C12G3/055A61P3/10
CPCA61P3/10A61K36/605C12G3/04A61K2236/39A61K2236/55A61K2236/51A61K2236/331
Inventor 江丹石万银陈志元
Owner 劲牌持正堂药业有限公司