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A method of using graphene oxide to improve the interface bonding performance of polyether ether ketone and polyvinyl alcohol composite bone scaffold

A technology of polyether ether ketone and polyvinyl alcohol, which is applied in prosthesis, tissue regeneration, additive processing, etc., can solve the problems of poor interface bonding, poor composite effect, poor compatibility, etc., to improve biological performance, Good hydrophilicity and good mechanical properties

Inactive Publication Date: 2020-04-24
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the defects of hydrophobicity and non-degradability of PEEK bone scaffold materials in the prior art, and the poor compatibility of PEEK and hydrophilic polymer materials, poor interface bonding, resulting in poor composite effects, etc., the purpose of the present invention is to provide A method for improving the binding properties of polyether ether ketone and polyvinyl alcohol by using GO rich in large π-conjugated structures and surface oxygen-containing functional groups. Binding ability, improve the interfacial properties between polyether ether ketone and polyvinyl alcohol, so as to obtain PEEK / PVA composite bone scaffold with better biological and mechanical properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Using an electronic balance, weigh 49.5 g of PEEK powder with a particle size of 40 μm and a melting point of 330° C.; 49.5 g of PVA powder with a particle size of 40 μm and a melting point of 220° C. Put the two powders into a beaker with 100ml of alcohol, and mix them evenly by magnetic stirring and ultrasonic dispersion;

[0026] 2) Use an electronic balance to weigh 1 g of GO powder with a thickness of 1 nm and a diameter of 3 μm. Put the powder into a beaker filled with 20ml of alcohol, and mix evenly by magnetic stirring and ultrasonic dispersion;

[0027] 3) Pour the above two solutions into the same beaker, and mix them uniformly by magnetic stirring and ultrasonic dispersion. The magnetic stirring time is 40min, the magnetic stirring speed is 600r / min, the stirring temperature is 50°C, and the ultrasonic dispersion time is 40min. , the ultrasonic dispersion temperature is 50°C;

[0028] 4) The mixed solution is filtered, dried, and ground to obtain a compo...

Embodiment 2

[0037] 1) Using an electronic balance, weigh 49.5 g of PEEK powder with a particle size of 40 μm and a melting point of 330° C.; 49.5 g of PVA powder with a particle size of 40 μm and a melting point of 220° C. Put the two powders into a beaker with 100ml of alcohol, and mix them evenly by magnetic stirring and ultrasonic dispersion;

[0038] 2) Use an electronic balance to weigh 1 g of GO powder with a thickness of 1 nm and a diameter of 3 μm. Put the powder into a beaker filled with 20ml of alcohol, and mix evenly by magnetic stirring and ultrasonic dispersion;

[0039]3) Pour the above two solutions into the same beaker, and mix them uniformly by magnetic stirring and ultrasonic dispersion. The magnetic stirring time is 40min, the magnetic stirring speed is 600r / min, the stirring temperature is 50°C, and the ultrasonic dispersion time is 40min. , the ultrasonic dispersion temperature is 50°C;

[0040] 4) The mixed solution is filtered, dried, and ground to obtain a compos...

Embodiment 3

[0044] 1) Using an electronic balance, weigh 49.5 g of PEEK powder with a particle size of 40 μm and a melting point of 330° C.; 49.5 g of PVA powder with a particle size of 40 μm and a melting point of 220° C. Put the two powders into a beaker with 100ml of alcohol, and mix them evenly by magnetic stirring and ultrasonic dispersion;

[0045] 2) Use an electronic balance to weigh 1 g of GO powder with a thickness of 1 nm and a diameter of 3 μm. Put the powder into a beaker filled with 20ml of alcohol, and mix evenly by magnetic stirring and ultrasonic dispersion;

[0046] 3) Pour the above two solutions into the same beaker, and mix them uniformly by magnetic stirring and ultrasonic dispersion. The magnetic stirring time is 40min, the magnetic stirring speed is 600r / min, the stirring temperature is 50°C, and the ultrasonic dispersion time is 40min. , the ultrasonic dispersion temperature is 50°C;

[0047] 4) The mixed solution is filtered, dried, and ground to obtain a compo...

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Abstract

The invention discloses a method for improving interface binding ability of polyether-ether-ketone and polyvinyl alcohol composite bone scaffold by using oxidized graphene. The method comprises the following steps: after mixing polyether-ether-ketone (PEEK) powder, polyvinyl alcohol (PVA) powder and oxidized graphene (GO) powder through a liquid phase, carrying out solid-liquid separation, dryingand grinding a solid to obtain composite powder; and preparing the composite powder into a composite bone scaffold through a laser 3D printing technology. According to the method, the oxidized graphene has preferable binding capacity with polyether-ether-ketone and polyvinyl alcohol, so that the interfacial properties between the polyether-ether-ketone and the polyvinyl alcohol are improved.

Description

technical field [0001] The invention relates to a preparation method of polyether ether ketone and polyvinyl alcohol composite bone scaffold, in particular to a method for improving the interfacial bonding performance of polyether ether ketone and polyvinyl alcohol composite bone scaffold by using graphene oxide, belonging to the technical field of bone scaffold preparation . Background technique [0002] Polyetheretherketone (PEEK) is a new polymer material with excellent comprehensive properties. It has excellent mechanical properties, good biocompatibility and processability, and has broad application prospects in the field of bone scaffolds. However, its The extremely strong hydrophobicity and non-degradability hinder cell adhesion and tissue growth, and the extremely strong hydrophobicity of polyetheretherketone leads to poor compatibility with hydrophilic polymer materials, and it is difficult to produce good interfacial bonding, affecting Therefore, there is no good ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/443A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L29/04C08L61/16
Inventor 冯佩帅词俊
Owner CENT SOUTH UNIV