Application of Flexible Transparent Carbon Nanotube Neural Electrode Arrays in Neural Optoelectronic Interfaces

A technology of electrode array and carbon nanotube film, which is applied in the field of materials to achieve high light transmittance, huge application potential, and favorable signal-to-noise ratio.

Active Publication Date: 2021-10-15
PEKING UNIV
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Problems solved by technology

In basic research, due to the huge amount of information in neural activities, it is necessary to collect information with high temporal / spatial resolution at the same time, and a single electrical recording technology or optical imaging technology cannot meet the requirements. Scientific research is of great significance

Method used

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  • Application of Flexible Transparent Carbon Nanotube Neural Electrode Arrays in Neural Optoelectronic Interfaces
  • Application of Flexible Transparent Carbon Nanotube Neural Electrode Arrays in Neural Optoelectronic Interfaces
  • Application of Flexible Transparent Carbon Nanotube Neural Electrode Arrays in Neural Optoelectronic Interfaces

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Embodiment 1

[0053] Example 1, carbon nanotube film in preparing applications with mechanical active nervous system devices

[0054] 1) Characterization of carbon nanotube thin film electrode properties

[0055] We characterize the CNT film electrode array from electrical properties, mechanical properties, and two angles. In terms of electrical properties, in order to initially measure the electrical properties of the microelectrode array in the biological fluid, we first use phosphate buffer Saline, PBS to simulate the body fluid environment, and determine the micro-microdetic three-point test method in electrolyte solution Impedance of electrode arrays at different frequencies. The so-called three-point test method is based on Ag / AGCL as the reference electrode, and platinum wire is the counter electrode, the microelectrode array is a working electrode, and its electrochemical impedance spectroscopy (Electrochemical Impedancespectroscopy, EIS) is measured.

[0056] The result of the result...

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Abstract

The invention discloses the application of a flexible transparent carbon nanotube nerve electrode array in a nerve electro-optical interface. The invention utilizes the characteristics that the carbon nanotube electrode array has high light transmittance in a wide wavelength range, and can still maintain excellent electrochemical properties and optical properties in a stretched state, and realizes electrophysiological signals of cortical epilepsy and two-photon Simultaneous in situ recording of calcium imaging, and real-time recording of EEG under photostimulation, allow observation of neural activity with high temporal / spatial resolution. Utilizing the superior flexibility and extensibility of the carbon nanotube electrode array, it can be used for real-time monitoring of brain electrical activity under brain injury; at the same time, the carbon nanotube electrode array can fit perfectly with the tissue to form a more efficient brain / The electrode interface is conducive to the improvement of the signal-to-noise ratio. The above results all reflect the great application potential of carbon nanotube electrode arrays in the nervous system, especially in the electro-optical interface of mechanically active systems.

Description

Technical field [0001] The present invention belongs to the field of material, and the application of a flexible transparent carbon nanotube neural electrode array in a neural electro-optical interface. Background technique [0002] During modern biomedical research and application, neurons connected to in vitro environments are important. In basic research, due to huge amounts of information in neurological activities, it is necessary to simultaneously collect information with high-time / spatial resolution, and single electrical recording technology or optical imaging techniques can meet the requirements, so the development of new photoelectric neurons face nerves. Scientific research is of great significance. In addition, the appearance of optical genetic technology provides more possibilities for accurate control of neurons. It has penetrated every corner of neuroscience. The researchers not only use it to study the basic function of the brain, but also explore the pathogenes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/05A61N1/36
CPCA61N1/0529A61N1/0551A61N1/36064
Inventor 段小洁曹安源张菁徐文静刘小军楚芳冰
Owner PEKING UNIV
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