Gentian compound extract and its preparation method and application

Abstract

The invention discloses gentian compound extract. The gentian compound extract is prepared from 10-25 parts by weight of gentian root, 5-20 parts by weight of radix scutellariae, 3-10 parts by weightof centella asiatica, 1-8 parts by weight of radix sophorae flavescentis, 1-5 parts by weight of licorice root, 1-5 parts by weight of a plant extract enzyme, 10-30 parts by weight of low molecular weight alcohol and 40-80 parts by weight of deionized water. The invention also provides a preparation method of the gentian compound extract. The preparation method comprises: raw material crushing, temperature difference method extraction, enzymatic hydrolysis extraction, enzyme inactivation treatment and extraction liquid filtration. The contents of the five raw materials and other components arecontrolled in the optimal range and have reasonable compatibility so that the inhibition rate of hyaluronidase activity can reach to 76%. The gentian compound extract can fast resist allergy and relieve itching to reduce patient's pain. The wall is broken through a temperature difference-enzymatic hydrolysis method so that the gentiopicroside content is 2180.5ppm and thus the extraction rate of the active ingredients is greatly improved, the problem that the traditional method easily causes viscous substance blocking in the filter in extraction is solved, the energy consumption and equipmentrequirements are reduced and large-scale production is feasible.

Description

technical field [0001] The invention relates to the technical field of natural product extraction, in particular to a compound extract of gentian and a preparation method and application thereof. Background technique [0002] Skin allergy refers to abnormal specific immune responses such as physiological dysfunction or body damage when the skin is stimulated by allergens. It is often accompanied by symptoms such as itching, redness, and scaling of the skin. There are currently four recognized ways of anti-allergic and anti-itching: (1) isolate allergens; (2) improve skin protection function, reduce skin sensitivity by repairing or enhancing skin barrier protection function, and play an anti-allergic effect; (3) Inhibit the release of inflammatory factors, by inhibiting the generation or release of mediator factors such as histamine and heparin; (4) Improve the skin's self-repair function, through the action of topical active substances, improve the skin's repair ability and...

AI Technical Summary

Problems solved by technology

Currently commonly used extraction techniques include solvent extraction, ultrasonic extraction, microwave extraction, supercritical fluid extraction, etc. Among them, solvent extraction has problems such as high extraction temperature, low extraction rate, and high cost; The location and other requirements are high, and there are problems such as engineering equipment amplification; the microwave extraction method has limitations that are only suitable for thermally stable substances; the supercritical fluid extraction method has problems such as poor solubility of water-soluble components, expensive equipment, and difficult cleaning.

[0005] For example, the Chinese patent with application number 201810033550.1 discloses "a kind of gentian extract and its extraction process". Insoluble or water-insoluble ingredients such as gentianine increase the yield of active ingredients, but because microwave heating is only suitable for thermally stable substances during extraction, there are certain limitations

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