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Micro-needle patch capable of intelligently regulating blood glucose and preparation method thereof

A technology of intelligent adjustment and microneedle sticking, applied in the field of biomedicine, can solve the problems of inability to achieve glucose levels, pain, and inconvenience for patients, and achieve good skin puncture effects, pain relief, and active protection effects

Active Publication Date: 2018-11-20
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional blood sugar detection needs to prick the finger to draw blood, repeated needle pricking blood
This method of blood sugar testing and drug injection not only brings inconvenience and pain to patients, but also requires long-term compliance
More importantly, the conventional treatment without direct coupling of glucose sensing and drug therapy cannot achieve strict regulation of the patient's glucose level.

Method used

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  • Micro-needle patch capable of intelligently regulating blood glucose and preparation method thereof
  • Micro-needle patch capable of intelligently regulating blood glucose and preparation method thereof
  • Micro-needle patch capable of intelligently regulating blood glucose and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of the medicine of embodiment 1 intelligent regulation blood sugar

[0029] (1) According to the method described in the applicant's previous patent application "Gold Nanocluster Particles for Intelligently Released Insulin to Regulate Blood Sugar and Its Preparation Method" (Application No. 201810075085.8, Publication No. CN 108079282 A) to prepare intelligently released insulin to regulate blood sugar Gold nanocluster particles (GNC-FPBA-Insulin or GNC-PBA-Insulin).

[0030] (2) Preparation of gold nanocluster particles (BSA-GNC-PBA-Insulin) responsive to blood glucose regulation

[0031] 1) Preparation of BSA-coated gold nanocluster particles (BSA-GNCs)

[0032] Contains HAuCl 4 . The BSA mixed solution was reacted at 35-40° C. for 10-18 h under the condition of pH ≥ 12 to obtain BSA-coated gold nanocluster particles (BSA-GNCs).

[0033] 2) Convert the amino groups on the surface of BSA to carboxyl groups

[0034] First add glutaraldehyde to the B...

Embodiment 2

[0042] Example 2 Preparation of microneedle patch for intelligent blood sugar regulation

[0043] (1) Microneedle template

[0044] The microneedle template was purchased from Blueacre Technology Company in Ireland. The microneedle template was made of silicone material, and its design and size were as follows: figure 1 As shown: the template contains a 11×11 array of conical hole structures, wherein the diameter of the upper base of each conical hole is 300-400 μm, the height is 600-800 μm, and the distance between adjacent conical holes is 600 μm.

[0045] (2) Preparation of microneedle patch

[0046] The preparation of the microneedle patch includes the following steps:

[0047] 1) Prepare a biocompatible hydrogel solution. For example, biocompatible hydrogels include gelatin / starch hydrogels, sodium alginate hydrogels, hyaluronic acid hydrogels, polyvinyl alcohol hydrogels, and the like.

[0048] 2) Adding drugs for intelligent regulation of blood sugar (GNC-FPBA-Insul...

Embodiment 3

[0053] Example 3 Using different hydrogel materials to prepare microneedle patches for intelligent regulation of blood sugar

[0054] According to the method in Example 2, different hydrogel materials were used to prepare smart blood sugar regulation.

[0055] (1) Gelatin / starch as hydrogel material

[0056] Dissolve starch and gelatin with a mass ratio of 1:1 in deionized water respectively, heat to 60°C, stir for 30 minutes to fully dissolve, and prepare gelatin and starch with a concentration of 5% (w / v) (total concentration of gelatin+starch 10%) gelatin / starch solution.

[0057] An appropriate amount of medicine for intelligently regulating blood sugar is added to the gelatin / starch solution to obtain a medicine-containing gelatin / starch solution.

[0058] Use a pipette gun to take 50 μL of drug-containing gelatin / starch solution and deposit it directly on the surface of the microneedle template, and place it under vacuum (400mmHg) for 15 minutes to remove the air bubbl...

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Abstract

The invention discloses a micro-needle patch capable of intelligently regulating blood glucose and a preparation method thereof, and belongs to the field of biomedicine. An intelligent micro-needle part of the micro-needle patch capable of adjusting blood glucose is filled with a medicine for intelligently adjusting blood glucose, and the medicine comprises a carrier material, glucose response sensitive switch factors and medicine molecules. A micro-needle of a micro-needle template is filled with a hydrogel solution containing the medicine through a vacuumizing and centrifugation method; re-centrifugation is carried out, a base of the micro-needle patch is prepared by using the hydrogel solution without the medicine, solidification of the hydrogel material is carried out through a propermethod, and after drying, the micro-needle patch is stripped from the template to obtain the micro-needle patch for intelligently adjusting the blood glucose. The micro-needle patch can puncture skin,insulin is intelligently released in the body according to the blood glucose concentration, and the blood glucose level is intelligently adjusted. According to the micro-needle patch, painless and intelligent response type blood glucose regulation is realized, and diabetes diagnosis and treatment integration is expected to be guided.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a microneedle patch for intelligently regulating blood sugar and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease in which high glucose in the body is caused by insufficient insulin secretion or impaired insulin biological action. Among them, type 1 diabetes is due to autoimmune destruction of pancreatic beta cells leading to insufficient insulin secretion, and type 2 diabetes is a combination of insulin resistance and impaired insulin secretion. In recent years, diabetes has become an increasingly serious threat to public health in the world. According to statistics, in 2017, there were about 425 million adult patients with type 1 and type 2 diabetes in the world, and China became the country with the largest population of diabetics in the world with 114.4 million adult patients. [0003] For patients with type 1 diabetes and advan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K47/69A61K47/54A61K47/52A61K38/28A61P3/10
CPCA61K38/28A61K47/52A61K47/54A61K47/6929A61M37/0015A61P3/10A61M2037/0023A61M2037/0061A61M2037/0053A61K9/0021A61M2037/0046A61K9/06A61K47/42
Inventor 雷祎凤刘胜张玉洁李银萍
Owner WUHAN UNIV
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