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Application of chickpea extract in preparation of drug for treating androgen-dependent diseases

A technology of chickpea and extract, applied in the field of medicine, can solve problems such as erectile dysfunction, abnormal sexual function, adverse reactions and the like

Active Publication Date: 2018-12-07
新疆维吾尔自治区分析测试研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some existing 5α-reductase inhibitors have been widely used clinically, but they all have strong adverse reactions, such as causing erectile dysfunction, abnormal sexual function, feminization of male breasts, etc.

Method used

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  • Application of chickpea extract in preparation of drug for treating androgen-dependent diseases
  • Application of chickpea extract in preparation of drug for treating androgen-dependent diseases
  • Application of chickpea extract in preparation of drug for treating androgen-dependent diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] Chickpea Extract Inhibition of 5α-Reductase Activity:

[0021] 1.1 Experimental method:

[0022] 1.1.1 Preparation of Chickpea Extract:

[0023] a. Select chickpeas with well-proportioned size and full grains, wash them with clean water for 3 times, add pure water to soak them for 2 hours, cultivate them at 28°C, and change the water every 12 hours. After 72 hours, the chickpea sprouts will grow to 2cm. It is divided into three parts: germinated chickpea hypocotyl A, germinated chickpea cotyledon B, and germinated chickpea whole bean C. After being freeze-dried by a freeze dryer, the prototype is crushed to obtain the germinated chickpea hypocotyl A powder, germinated chickpea cotyledon B powder and germinated chickpea whole bean C powder;

[0024] b. Select chickpea dried beans in addition, grind the sample with a pulverizer, and obtain ungerminated whole bean D powder of chickpeas;

[0025] c. Weigh the germinated chickpea hypocotyl A powder, germinated chickpea co...

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Abstract

The invention relates to application of a chickpea extract in the preparation of a drug for treating androgen-dependent diseases. The chickpea extract is prepared by the steps of sprouting chickpeas,carrying out freeze-drying crushing, extraction and concentration so as to obtain extracts of sprouted chickpea hypocotyls A, sprouted chickpea cotyledons B, sprouted whole chickpeas C and non-sprouted whole chickpeas, carrying out bioactive screening by virtue of a 5-alpha reductase in-vitro screening model, so as to obtain an optimal active component, namely the sprouted chickpea hypocotyls A. The chickpea extract has wide medical application prospects in the field of the drug for treating the androgen-dependent diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application of chickpea extracts in the preparation of medicines for treating androgen-dependent diseases. Background technique [0002] China has gradually entered an aging society, androgen-dependent diseases have received more and more attention, such as acne, hirsutism, androgenetic alopecia, benign prostatic hyperplasia (BPH) and prostate cancer. In particular, benign prostatic hyperplasia (BPH) is more common in middle-aged and elderly people. The incidence rate of men over 50 years old is nearly 40%, the incidence rate of men over 65 years old is nearly 70%, and the incidence rate of men over 70 years old is nearly 90%. For patients with BPH, due to the oppression of the urethra by the hypertrophy of the prostate tissue, it will cause poor urination and dysuria, and more serious cases may cause urinary retention, which is very painful for the patient. It can be seen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P5/28A23L33/105A61K131/00
CPCA23V2200/00A61K36/48A61K2236/333A61K2236/39A61K2236/51A23L33/105A61P5/28A23V2200/30A23V2250/21
Inventor 王苗苗李慕春韩飞
Owner 新疆维吾尔自治区分析测试研究院
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