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Compound containing imatinib and plant polysaccharide

A technology of plant polysaccharide and composition, applied in the field of medicine

Inactive Publication Date: 2018-12-18
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the prior art, there is no technical inspiration for using the combination of imatinib and plant polysaccharides to produce a synergistic anti-tumor effect

Method used

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  • Compound containing imatinib and plant polysaccharide
  • Compound containing imatinib and plant polysaccharide
  • Compound containing imatinib and plant polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1 Preparation of capsules comprising imatinib mesylate and ganoderma polysaccharide

[0074] Prescription (according to 100 capsules)

[0075]

[0076] Preparation

[0077] Get the prescribed amount of imatinib mesylate, ganoderma polysaccharide, microcrystalline cellulose and sodium stearyl fumarate, mix thoroughly, fill capsules, and pack separately to obtain 100 capsules.

Embodiment 2

[0078] Embodiment 2 The preparation of the capsule comprising imatinib mesylate and Yunzhi polysaccharide

[0079] Prescription (according to 100 tablets)

[0080]

[0081]

[0082] Preparation

[0083] Take the prescribed amount of imatinib mesylate, versicolor polysaccharide, microcrystalline cellulose and sodium stearyl fumarate, fully mix, and press into 100 tablets.

Embodiment 3

[0084] Example 3 Preparation of Capsules Comprising Imatinib Mesylate and Astragalus Polysaccharide

[0085] prescription

[0086]

[0087] Preparation

[0088] Take the prescribed amount of imatinib mesylate, astragalus polysaccharide, microcrystalline cellulose and sodium stearyl fumarate, mix them thoroughly, and pack them separately.

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Abstract

The invention provides a compound containing imatinib or pharmaceutically acceptable salt of the imatinib and plant polysaccharide. The plant polysaccharide is selected from one of ganoderma lucidum polysaccharide, coriolus versicolor polysaccharide and cynanchum otophyllum polysaccharide. Animal tests show that the compound can generate a synergistic anti-tumor effect on liver cancer, gastric cancer, a lung carcinoma model, gallbladder carcinoma and / or kidney cancer.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition containing imatinib and plant polysaccharides. Background technique [0002] Imatinib (also known as STI-571, CGP57148B) is a phenylaminopyrimidine derivative with a chemical name of (4-[(4-methyl-1-piperazine)methyl]-N-[ 4-Methyl-3-{(4-(3-pyridine)2-pyrimidine)}amino]phenyl)aniline, its mesylate salt for medicinal purposes, its structural formula is shown below. [0003] [0004] Imatinib is a selective tyrosine kinase inhibitor, which inhibits its tyrosine kinase activity by competitively binding to the ATP-binding site on BCR-ABL kinase, blocking the kinase's autophosphorylation and Substrate phosphorylation level, thereby specifically inhibiting the proliferation of BCR-ABL positive cells and inducing their apoptosis. The FDA-approved indications for imatinib include hematological tumors such as chronic myeloid leukemia (CML) and solid tumors such as gastr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P35/00A61K31/506
CPCA61K31/506A61K31/715A61P35/00A61K2300/00
Inventor 向飞周婷孙伟光黄泳华
Owner 黄泳华
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