Radix isatidis syrup and preparation method thereof

A technology of Radix Radix and Syrup, which is applied in the direction of pharmaceutical formula, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of product quality stability between batches, clinical efficacy cannot be guaranteed, and the appearance of Radix Radix Syrup Problems such as dark color and unsuitable for children to take to achieve the effect of improving consumer experience, improving product effectiveness and quality stability, and improving appearance properties

Inactive Publication Date: 2018-12-18
YAAN THREE NINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation method of Banlangen syrup only conforms to the general rules of syrup preparation, and the quality stability and clinical efficacy of the product between batches cannot be guaranteed.
Moreover, Radix Radix Syrup has a dark appearance and a fishy smell, so it is not suitable for children to take

Method used

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  • Radix isatidis syrup and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation method of Radix Radix Radix syrup described in the present embodiment, comprises the steps:

[0048] (1) Select Radix Radix:

[0049] Pulverize the Radix isatidis medicinal material and pass through a No. 4 sieve to obtain the Radix Radix isatidis powder; weigh 2.5 g of the Radix Radix isatidis powder, place it in a 100 mL conical flask with a stopper, add 25 mL of ethanol aqueous solution with a mass fraction of 80%, seal it, and weigh it;

[0050]Ultrasonic treatment for 60 minutes, the ultrasonic conditions are: power 530W, frequency 60kHz; Filter with filter paper, and get the continued filtrate;

[0051] Heat the subsequent filtrate in a water bath at 30°C for 10 minutes, take it out and test it quickly at room temperature, take the ethanol aqueous solution with a mass fraction of 80% as a blank, measure at a wavelength of 440nm, record the absorbance, and select the isatidis corresponding to the subsequent filtrate with an absorbance ≤ 0.70 powde...

Embodiment 2

[0059] The preparation method of Radix Radix Radix syrup described in the present embodiment, comprises the steps:

[0060] (1) Select Radix Radix:

[0061] Pulverize the Radix isatidis medicinal material and pass through a No. 4 sieve to obtain the Radix Radix isatidis powder; weigh 2.5 g of the Radix Radix isatidis powder, place it in a 100 mL conical flask with a stopper, add 25 mL of ethanol aqueous solution with a mass fraction of 80%, seal it, and weigh it;

[0062] Ultrasonic treatment for 60 minutes, the ultrasonic conditions are: power 530W, frequency 60kHz; Filter with filter paper, and get the continued filtrate;

[0063] Heat the subsequent filtrate in a water bath at 30°C for 10 minutes, take it out and test it quickly at room temperature, take the ethanol aqueous solution with a mass fraction of 80% as a blank, measure at a wavelength of 440nm, record the absorbance, and select the isatidis corresponding to the subsequent filtrate with an absorbance ≤ 0.70 powd...

Embodiment 3

[0071] The preparation method of Radix Radix Radix syrup described in the present embodiment, comprises the steps:

[0072] (1) Select Radix Radix:

[0073] Pulverize the Radix isatidis medicinal material and pass through a No. 4 sieve to obtain the Radix Radix isatidis powder; weigh 2.5 g of the Radix Radix isatidis powder, place it in a 100 mL conical flask with a stopper, add 25 mL of ethanol aqueous solution with a mass fraction of 80%, seal it, and weigh it;

[0074] Ultrasonic treatment for 60 minutes, the ultrasonic conditions are: power 530W, frequency 60kHz; Filter with filter paper, and get the continued filtrate;

[0075] Heat the subsequent filtrate in a water bath at 30°C for 10 minutes, take it out and test it quickly at room temperature, take the ethanol aqueous solution with a mass fraction of 80% as a blank, measure at a wavelength of 440nm, record the absorbance, and select the isatidis corresponding to the subsequent filtrate with an absorbance ≤ 0.70 powd...

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Abstract

The invention relates to the technical field of medicine preparation, in particular to radix isatidis syrup and a preparation method thereof. The preparation method of the radix isatidis syrup comprises the following steps: selecting radix isatidis, using water as a solvent, and extracting the radix isatidis in a circulating way at 65-80 DEG C, collecting extract and concentrating, and carrying out centrifugal filtration to obtain radix isatidis liquid medicine; dissolving sucrose into water for boiling, and mixing the boiled product with the radix isatidis liquid medicine to obtain the radixisatidis syrup. The preparation method provided by the invention extracts the radix isatidis in a circulating way under the low temperature condition, so that the degradation of the extracted components such as polysaccharides and amino acids can be avoided, the content of (R-S)-epigoitrin is increased, and the product effectiveness and the quality stability are improved; furthermore, the concentrated liquid is centrifuged, and the color of the liquid medicine is controlled from the raw materials, so that the clarity of the liquid medicine is improved; the sucrose is processed by using boilingprocess, so that the aromatic degree of the liquid medicine can be improved; the product taste and the consumer experience are improved on the basis of not adding other flavoring auxiliary materials.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a Radix isatidis syrup and a preparation method thereof. Background technique [0002] Isatis root is the dried root of the cruciferous plant Isatis indigo, which has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. Clinically, it is widely used in the treatment of influenza, mumps, acute and chronic pharyngitis, and herpes simplex keratitis. [0003] Isatidis preparations include Isatidis Injection, Isatidis Granules, Isatidis Capsules, Isatidis Oral Liquid, Isatidis Syrup, etc. [0004] At present, the preparation method of Radix Radix Radix Syrup only conforms to the general rules of syrup preparation, and the quality stability and clinical efficacy of the product between batches cannot be guaranteed. Moreover, Radix Radix Radix Syrup has a dark appearance and a fishy smell, which is not suitable for children to take. [0005] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/315A61K9/08A61K47/26A61P11/04A61P29/00A61P31/14A61P1/16A61P31/20
CPCA61K47/26A61P1/16A61P11/04A61P29/00A61P31/14A61P31/20A61K9/0095A61K36/315A61K2236/53A61K2236/331
Inventor 侯新莲袁海英蔡帮军周鑫
Owner YAAN THREE NINE PHARMA
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