Method for measuring glycated hemoglobin and device for measuring glycated hemoglobin

A technology of glycosylated hemoglobin and hemoglobin, applied in the field of glycosylated hemoglobin, can solve problems such as difficult to reflect symptoms
CN109073616BActive Publication Date: 2020-10-09TOSOH CORP

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TOSOH CORP
Publication Date
2020-10-09

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Abstract

The object of the present invention is to eliminate the influence of the abnormal hemoglobin when measuring a blood sample containing abnormal hemoglobin D, abnormal hemoglobin S, or abnormal hemoglobin C by cation exchange chromatography, and to obtain a test result reflecting the subject who provided the blood sample. Symptomatic SA1c measurement results. The present invention solves the above-mentioned problems by a method for measuring the ratio (%) of SA1c, which is characterized in that, when a peak derived from abnormal hemoglobin D, abnormal hemoglobin S, or abnormal hemoglobin C is identified, the area of ​​the peak is calculated, The ratio (%) of the corrected SA1c was determined using the calculation result.
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Description

technical field

[0001] The present invention relates to a method and device for measuring glycated hemoglobin in a blood sample by liquid chromatography, and more particularly to a glycated hemoglobin capable of measuring glycated hemoglobin as a diagnostic index for diabetes in a blood sample group in which blood samples containing abnormal hemoglobin may be mixed measuring method and measuring device. Background technique

[0002] Hemoglobin has an α2β2 structure consisting of 2 α chains and 2 β chains. In addition to hemoglobin A, which accounts for about 97% of the total hemoglobin, it is composed of hemoglobin F and hemoglobin A2. The hemoglobin F has 2 α chains and 2 The α2γ2 structure composed of γ chains accounts for less than 1% of the total hemoglobin, and the hemoglobin A2 has an α2δ2 structure composed of two α chains and two δ chains and accounts for less than 1% of the total hemoglobin.

[0003] Hemoglobin non-enzymatically combines with sugar (blood sugar) pr...

Claims

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