Serum exosomal protein markers in obstructive sleep apnea-hypopnea syndrome and their applications

Abstract

The invention provides serum exosomal protein markers for obstructive sleep apnea hypopnea syndrome and applications thereof. Specifically, the present invention provides the application of detection reagents for protein markers in the preparation of kits for detecting obstructive sleep apnea hypopnea syndrome, wherein the protein markers are selected from C-reactive protein, binding beads protein and fibronectin, the kit detects the concentration of the protein marker in the serum exosomes of the subject, wherein compared with the normal control, C-reactive protein in the serum exosomes of the subject Elevated concentrations, increased haptoglobin concentrations, and / or decreased fibronectin concentrations indicate an increased probability of obstructive sleep apnea-hypopnea syndrome. The invention also provides related kits and detection systems. The concentration changes of the above three protein markers derived from serum exosomes can be used to detect obstructive sleep apnea hypopnea syndrome.

Description

technical field [0001] The invention relates to the field of obstructive sleep apnea hypopnea syndrome, in particular to a serum exosome protein marker related to obstructive sleep apnea hypopnea syndrome and its application. Background technique [0002] Among sleep disorders, the most common is Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). OSAHS is an independent risk factor for cardiovascular and cerebrovascular diseases and is also associated with excessive daytime sleepiness leading to mental decline, mood changes, and increased motor vehicle accidents. The latest "Sleep White Paper" shows that 20.4% of adults in our country suffer from OSAHS. In the United States, uncontrolled moderate-to-severe OSAHS will increase personal health consumption by 2700-3000 US dollars per year, and the total annual economic cost will reach 65-165 billion US dollars. At present, there is still a lack of research on the impact of OSAHS on health consumption in my country, but it is ...

AI Technical Summary

Problems solved by technology

However, the diagnosis of PSG has the following problems: A. The PSG diagnosis data of OSAHS needs to be analyzed and interpreted by professionals with certain technical training and reviewed by sleep experts certified by the committee. The detection process is complex, time-consuming and expensive, and cannot meet the needs of large-scale clinical screening of OSAHS patients; B. For patients, this diagnostic technology is not convenient enough, and overnight bedside detection and wearing of a large number of sensors in hospitals or clinical facilities are also inconvenient. It will affect the patient's mood, which will affect the accuracy of the monitoring results

Such a complex composition also makes the function of exosomes present the characteristics of dynamics, diversity and complexity, and the current research is far from fully revealing

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