A kind of lyotropic liquid crystal drug carrier and preparation method and application
A technology of lyotropic liquid crystals and ethyl oleate, which is applied in the direction of drug combinations, pharmaceutical formulas, antipyretics, etc., to achieve the effects of improving drug solubility and stability, good sustained release effect, and improving drug release properties
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[0053] 1. Drawing of phase diagram
[0054] First, according to the molar ratio of 4 / 1, accurately weigh the surfactant and place it in a colorimetric tube, and mix well; secondly, according to the change of the ratio of the surfactant to the oil phase from 10:0 to 0:10, accurately weigh the oleic acid in sequence Ethyl ester in different colorimetric tubes, stir and mix well; finally, add double distilled water drop by drop to the colorimetric tubes, the percentage of water increases at intervals of 2%, use magnetic stirring in a water bath at 40-50°C Stir evenly with a mixer, then place in a water bath at 25°C to balance, observe and record the changes in the phase state and appearance of the aggregates, and it is necessary to extend the equilibrium time of the aggregates when approaching the phase boundary. The phase boundary is preliminarily judged by visually observing the color, transparency, hardness, viscosity, etc. of the aggregates.
[0055] 2. Preparation of sample...
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