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A modified electrode and a method for electrochemically detecting sulpiride

An electrochemical, glassy carbon electrode technology, applied in the electrochemical detection of Sulpiride, α-MoO3 nanorod modified glassy carbon electrode field, can solve the problems of low efficiency of Sulpiride, long analysis time, high catalytic activity, etc., to achieve strong application value , The effect of high electrochemical activity and high sensitivity

Active Publication Date: 2020-12-25
山东信开源科技创新发展有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The methods for determining the content of sulpiride and pharmacokinetics mainly include ultraviolet absorption spectroscopy, fluorescence photometry, thin-layer scanning, capillary electrophoresis, etc. These chromatographic or spectral analysis methods are expensive in equipment, complicated in operation, and long in analysis time, etc. Weaknesses, needs improvement
[0004] Molybdenum oxide has the advantages of wide band gap, small resistivity and high catalytic activity. And its method for the electrochemical detection of sulpiride has not been reported so far
The present invention proposes an electrochemically modified electrode and a detection method for solving the low efficiency of chromatographic or spectroscopic detection of sulpiride and improving the electrochemical catalytic effect and detection sensitivity of electrochemical detection of sulpiride

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  • A modified electrode and a method for electrochemically detecting sulpiride

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Embodiment 1

[0024] Preparation of α-MoO 3 Nanorod modified glassy carbon electrode:

[0025] (1) α-MoO 3 Preparation of powder: ultrasonically disperse anhydrous sodium molybdate and hydrochloric acid in deionized water at a molar ratio of 1:3, then transfer the dispersion to a polytetrafluoroethylene high-pressure reactor, and place the reactor in a heating device 1 h at 150°C, cooled naturally to room temperature, filtered, dried, and then placed in a tube furnace and calcined at 350°C for 1 h in an air atmosphere to obtain α-MoO 3 powder;

[0026] (2) Glassy carbon electrode pretreatment: the glassy carbon electrode was polished with 0.1 μm and 0.05 μm alumina powder for 2 minutes in turn, and polished to a mirror surface, and the polished glassy carbon electrode was ultrasonically cleaned with acetone and deionized water for 3 minutes, respectively, to obtain Pretreated glassy carbon electrodes;

[0027] (3)α-MoO 3 Nanorod-modified glassy carbon electrodes: using prepared α-MoO ...

Embodiment 2

[0029] Preparation of α-MoO 3 Nanorod modified glassy carbon electrode:

[0030] (1) α-MoO 3 Powder preparation: ultrasonically disperse anhydrous sodium molybdate and hydrochloric acid in deionized water at a molar ratio of 1:7, then transfer the dispersion to a polytetrafluoroethylene high-pressure reactor, and place the reactor in a heating device In 190°C, hydrothermal reaction was carried out for 4h, naturally cooled to room temperature, filtered, dried, then placed in a tube furnace, and calcined at 500°C for 4h in an air atmosphere to obtain α-MoO 3 powder;

[0031] (2) Glassy carbon electrode pretreatment: the glassy carbon electrode was polished with 0.1 μm and 0.05 μm alumina powder for 2 minutes in turn, and polished to a mirror surface, and the polished glassy carbon electrode was ultrasonically cleaned with acetone and deionized water for 3 minutes, respectively, to obtain Pretreated glassy carbon electrodes;

[0032] (3)α-MoO 3 Nanorod-modified glassy carbon...

Embodiment 3

[0034] α-MoO 3 Preparation of nanorod modified glassy carbon electrodes:

[0035] (1) α-MoO 3 Preparation of powder: ultrasonically disperse anhydrous sodium molybdate and hydrochloric acid in deionized water at a molar ratio of 1:5, then transfer the dispersion to a polytetrafluoroethylene high-pressure reactor, and place the reactor in a heating device in 170°C for 2h, cooled to room temperature naturally, filtered, dried, and then placed in a tube furnace, calcined at 400°C for 2h in an air atmosphere to obtain α-MoO 3 powder;

[0036] (2) Glassy carbon electrode pretreatment: the glassy carbon electrode was polished with 0.1 μm and 0.05 μm alumina powder for 2 minutes in turn, and polished to a mirror surface, and the polished glassy carbon electrode was ultrasonically cleaned with acetone and deionized water for 3 minutes, respectively, to obtain Pretreated glassy carbon electrodes;

[0037] (3)α-MoO 3 Nanorod-modified glassy carbon electrodes: using prepared α-MoO ...

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Abstract

The invention discloses an electrochemical detection method for sulpiride. The method comprises the steps of preparing alpha-MoO3 powder by a hydro-thermal synthesis method, and depositing alpha-MoO3in the form of nanometer rods on the surface of a pretreated glassy carbon electrode by using a thermal evaporation method; preparing the sulpiride into standard solution with different concentrationsby using Tris-HCl, adjusting the pH value of the solution, soaking the glassy carbon electrode modified by the alpha-MoO3 nanometer rods into the solution to perform differential pulse volt-ampere detection, preparing a peak current-concentration standard curve, and displaying a good linear relation; and placing the modified electrode into the solution to be detected for detecting, and working out the concentration of the sulpiride in the solution to be detected according to the standard curve. The method can quickly measure the concentration of the sulpiride, the measurement limit reaches 1.0*10<-8>mol / L, the linear range is 5.0*10<-8>-1.0*10<-5>, and the sensitivity is high.

Description

technical field [0001] The present invention relates to a modified electrode and its application, further, to a kind of α-MoO 3 Nanorod modified glassy carbon electrode and its application in electrochemical detection of sulpiride. Background technique [0002] Sulpiride, also known as Zhivoling, is a sulfonamide derivative and a selective antagonist of central dopamine receptors. It has strong antipsychotic and antiemetic effects, as well as mental stimulation. Withdrawal, stupor, depression, hallucinations, delusions and other symptoms have a good curative effect, and it is a kind of psychotropic drug that has developed rapidly in recent years. [0003] The methods for determining the content of sulpiride and pharmacokinetics mainly include ultraviolet absorption spectroscopy, fluorescence photometry, thin-layer scanning, capillary electrophoresis, etc. These chromatographic or spectral analysis methods are expensive in equipment, complicated in operation, and long in ana...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/48G01N27/30C23C14/24C23C14/08
CPCC23C14/083C23C14/24G01N27/308G01N27/48
Inventor 孟青
Owner 山东信开源科技创新发展有限责任公司