Eye drop composition containing nacre powder for relieving eye fatigue, preparation method and application

A technology of nacre powder and eye drops, which is applied in the field of medicine, can solve problems such as irreversible damage to the cornea, irritation of the cornea, and increased irritation, and achieve the effects of relieving eye fatigue, reducing irritation, and prolonging the action time Effect
CN109260145BActive Publication Date: 2020-12-22湖北远大天天明制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
湖北远大天天明制药有限公司
Publication Date
2020-12-22

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Abstract

A liquid eye drop composition containing nacreous layer powder for relieving eye fatigue is provided. The liquid eye drop composition is characterized by comprising an active ingredient, adjuvant andsolvent, the active ingredient is composed of nacreous layer powder, borneol, zinc gluconate and carboxymethyl chitosan. The carboxymethyl chitosan used in the formula is a natural product, safe, non-toxic, and inherently preservative, which can make the new formula without or with less preservatives and reduce the irritation of the eye drops. At that same time, the eye drop composition doe not add the polyvinyl alcohol in the original drug, which can improve the problem that the pH drops dure the storage period of the drug, resulting in the eye irritation enhancement of the patient: the inventor found that the polyvinyl alcohol can catalyze the ester bond cleavage in the zinc gluconate, thereby dissociating the carboxyl group, so that the pH drops too fast. Furthermore, the use of carboxymethyl chitosan can also increase the viscosity of eye drops, which helps to prolong the action time of the drug, and can enhance the effect of relieving eye fatigue.
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Description

technical field

[0001] The invention relates to an eye drop, which belongs to the field of medicine. Background technique

[0002] Existing eye drop composition containing nacre powder can relieve eye fatigue, it contains nacre powder, borneol, zinc gluconate, polyvinyl alcohol and osmotic pressure regulator (sodium chloride), pH regulator (citrate) sodium citrate), solubilizer (Tween 80), solubilizer (ethanol) and preservatives (phenoxyethanol, benzalkonium chloride, ethylparaben, etc.).

[0003] During the later use of the eye drops of this formula, due to the solubilizer (Tween 80), solubilizer (ethanol) and preservatives (phenoxyethanol, benzalkonium chloride, ethyl paraben, etc.) used in the formula Both are irritating to the cornea, especially preservatives may cause irreversible damage to the cornea.

[0004] In addition, relevant literature reports that the pH of the formula will drop during long-term storage, which will lead to further acidification and increase t...

Claims

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