Binder-type hydrogel, and preparation method and application thereof

A hydrogel and adhesive technology, which is used in drug combinations, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of loss, insufficient mechanical strength of hydrogels, etc., and achieve tight force and improve viscosity. , good biocompatibility

Active Publication Date: 2019-01-25
朱飞燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the contradiction between the viscosity and the optimization of mechanical properties of the scaffold material hydrogel of the current cartilage tissue engineering, and solve the problem

Method used

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Example Embodiment

[0021] Specific embodiment 1: In this embodiment, the binder type hydrogel is compounded (introduced) bridging polymer on the surface of the hybrid hydrogel, wherein the hybrid hydrogel is the chitosan or chitosan derivative and The polyethylene glycol cross-linked hydrogel is obtained by hybridizing inorganic nanoparticles; the polyethylene glycol is a polyethylene glycol whose end groups are aldehyde groups; and the bridging polymer includes biological macromolecules Materials and inorganic nanoparticles; among them, the biological macromolecular materials are chitosan, chitosan derivatives, gelatin or collagen;

[0022] The inorganic nanoparticles are silica nanoparticles, hydroxyapatite nanoparticles, alumina nanoparticles or nano silver.

[0023] In this embodiment, polyethylene glycol whose end group is an aldehyde group can be directly synthesized by RAFT, or can be obtained by reacting polyethylene glycol with a small molecule compound containing an aldehyde group. Small m...

Example Embodiment

[0025] Specific embodiment two: this embodiment is different from specific embodiment one in that the derivative of chitosan is carboxymethyl chitosan or hydroxyethyl chitosan.

Example Embodiment

[0026] Specific embodiment three: This embodiment is different from specific embodiment one or two in that the molecular weight of the polyethylene glycol is 500-10k Da.

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PUM

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Abstract

A binder-type hydrogel and its preparation method and application are disclosed. The present invention belongs to the field of hydrogel, and aims to solve the problem that the mechanical strength of hydrogel is not enough in the application process of cartilage tissue engineering, and the hydrogel is easy to be lost from tissue. The binder-type hydrogel of the invention is a composite bridging polymer on the surface of a hybrid hydrogel, wherein the hybrid hydrogel is a hydrogel crosslinked by chitosan or a derivative of chitosan and polyethylene glycol, and inorganic nanoparticles are hybridized in the hydrogel, and the bridging polymer comprises a biomacromolecular material and inorganic nanoparticles. The preparation method comprise the following steps: 1, mixing that chitosan solutionand the polyethylene glycol solution to obtain a hydrogel; 2, mixing that biomacromolecular material solution and the inorganic nanometer particles to obtain a bridging polymer; and 3, the bridging polymer adheres to the surface of the hydrogel. The adhesive hydrogel of the invention is used for preparing a scaffold material in cartilage damage repair, and has excellent mechanical properties and adhesion strength due to the addition of inorganic nanoparticles.

Description

technical field [0001] The invention belongs to the field of hydrogels, in particular to a hydrogel with strong viscosity on a wet surface and its preparation and application. Background technique [0002] Currently, cartilage damage due to improper exercise is increasing. In addition, excessive walking and long-term weight bearing are common causes of osteoarticular cartilage defects. Once the articular cartilage is damaged, it cannot repair itself, and the prognosis is poor, and there is no specific treatment. At present, the research of cartilage tissue engineering has brought great hope for the treatment of cartilage damage. The three basic elements of tissue engineering are scaffold materials, seed cells and growth factors. The current scaffold materials are easy to lose from the tissue site, which seriously limits the clinical application of the scaffold materials. Therefore, it is imminent to develop a scaffold material with strong adhesion. [0003] Recently, "S...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/20A61L27/18A61L27/02A61L27/12A61L27/04A61L27/22A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56A61K47/36A61K47/10A61K47/02A61K47/04A61K47/42A61P19/04
CPCA61K47/02A61K47/10A61K47/36A61K47/42A61L27/025A61L27/047A61L27/12A61L27/18A61L27/20A61L27/222A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56A61L2300/412A61L2400/12A61L2430/06A61P19/04C08L5/08C08L71/02
Inventor 朱飞燕熊建义梁仟朱天飞
Owner 朱飞燕
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