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Medical hemostatic fibrous material with adsorption performance, and preparation method thereof

A hemostatic fiber and absorbent technology, applied in the field of absorbent medical hemostatic fiber material and its preparation, can solve the problems of allergic reaction, slow dissolution, poor blood coagulation, etc., and achieve anti-inflammatory reaction, good biocompatibility, and hemostatic effect Good results

Inactive Publication Date: 2019-02-01
李忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hemostatic gauze, hemostatic sponge, etc. often have residues in the body, causing adverse reactions to patients, and have poor curative effect, slow hemostasis, and troublesome operation
Thrombin injection for hemostasis is a physiological hemostasis method, but its cost is high, and it is difficult for ordinary patients to accept the high medical expenses
[0003] Later, a kind of hemostatic fiber fabric was developed, which was made by processing natural fibers, but its dissolution was slow and its coagulation property was poor, so there were still many deficiencies.
In recent years, people have turned their attention to gelatin, collagen, chitosan, etc. with good biocompatibility, but gelatin and collagen are mainly derived from pig bones or bovine bones, which may cause allergic reactions, and there is also a risk of mad cow disease, and the absorption rate is low ; Chitosan is expensive and slow to absorb

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of an absorbent medical hemostatic fiber material, the specific steps are as follows:

[0034] (1) The pretreated mung bean starch is treated with amylase to obtain amylase hydrolyzate, which is set aside;

[0035] (2) Silk fibroin is made after degumming, dissolved in water to make silk fibroin solution, and set aside;

[0036] (3) Add polyamino acid to the silk fibroin solution obtained in step (2), stir to dissolve, and then add polylactic acid-glycolic acid copolymer, mannuronic acid polymer, lunacin and the polyaminoacid obtained in step (1) while stirring. The amylase hydrolyzate was subjected to ultrasonic vibration for 1 hour to obtain the spinning stock solution;

[0037] (4) The spinning stock solution is spun by centrifugal method, rapidly dried into shape, freeze-dried, packaged and sterilized to obtain the finished product.

[0038] Among them, in step (1), the pretreatment method of mung bean starch is: add mung bean starch to 3 time...

Embodiment 2

[0048] A preparation method of an absorbent medical hemostatic fiber material, the specific steps are as follows:

[0049] (1) The pretreated mung bean starch is treated with amylase to obtain amylase hydrolyzate, which is set aside;

[0050] (2) Silk fibroin is made after degumming, dissolved in water to make silk fibroin solution, and set aside;

[0051] (3) Add polyamino acid to the silk fibroin solution obtained in step (2), stir to dissolve, and then add polylactic acid-glycolic acid copolymer, mannuronic acid polymer, lunacin and the polyaminoacid obtained in step (1) while stirring. The amylase hydrolyzate was subjected to ultrasonic vibration for 2 hours to obtain the spinning stock solution;

[0052] (4) The spinning stock solution is spun by centrifugal method, rapidly dried into shape, freeze-dried, packaged and sterilized to obtain the finished product.

[0053] Among them, in step (1), the pretreatment method of mung bean starch is: add mung bean starch to 4 tim...

Embodiment 3

[0063] A preparation method of an absorbent medical hemostatic fiber material, the specific steps are as follows:

[0064] (1) The pretreated mung bean starch is treated with amylase to obtain amylase hydrolyzate, which is set aside;

[0065] (2) Silk fibroin is made after degumming, dissolved in water to make silk fibroin solution, and set aside;

[0066] (3) Add polyamino acid to the silk fibroin solution obtained in step (2), stir to dissolve, and then add polylactic acid-glycolic acid copolymer, mannuronic acid polymer, lunacin and the polyaminoacid obtained in step (1) while stirring. The amylase hydrolyzate was subjected to ultrasonic vibration for 1 hour to obtain the spinning stock solution;

[0067] (4) The spinning stock solution is spun by centrifugal method, rapidly dried into shape, freeze-dried, packaged and sterilized to obtain the finished product.

[0068] Among them, in step (1), the pretreatment method of mung bean starch is: add mung bean starch to 4 time...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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PUM

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Abstract

The invention provides a medical hemostatic fibrous material with adsorption performance, and a preparation method thereof. The medical hemostatic fibrous material with adsorption performance is prepared taking silk fibroin, poly amino acid, polylactic acid-glycolic acid copolymer, mannuronic acid polymer, lunasine, and starch enzymatic hydrolysate as main raw materials, possesses excellent biocompatibility, can be degraded and adsorbed in vivo, is capable of stopping bleeding rapidly, is excellent in hemostatic effect, is capable of eliminating inflammation and inhibiting bacteria, and is capable of preventing inflammatory reaction.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an absorbent medical hemostatic fiber material and a preparation method thereof. Background technique [0002] Blood is an important link in the operation of various departments in the hospital, and plays a very important role in the success of the operation and the safety of the patient. There are two methods of hemostasis that doctors usually use in surgery, one is to use hemostatic gauze or hemostatic sponge, and the other is to use thrombin injection to stop bleeding. These two methods have great limitations. Hemostatic gauze, hemostatic sponge, etc. often have residues in the body, causing adverse reactions to patients, and poor curative effect, slow hemostasis, and troublesome operation. Thrombin injection for hemostasis is a physiological hemostasis method, but its cost is high, and it is difficult for ordinary patients to accept the high medical expenses. [0...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/04A61L24/00
CPCA61L24/0005A61L24/0015A61L24/0036A61L24/0042A61L24/046A61L24/108A61L2300/404A61L2300/418A61L2300/45A61L2400/04C08L89/00C08L77/04C08L67/04C08L29/14
Inventor 叶秀清李忠
Owner 李忠
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