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Application of shayacha extract in preparation of anti-alcohol product

The technology of Shiya tea and extract is applied in the field of medical technology and health care products, and can solve the problems such as not being well developed and utilized, so as to prolong the incubation period of intoxication and the climbing time, improve the activity of acetaldehyde dehydrogenase, and reduce the concentration of ethanol. Effect

Active Publication Date: 2019-02-15
广州华农大营养科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Shiya tea is a kind of tea that people like, it has not been well developed and utilized, especially the application of Shiya tea extract in the preparation of food or medicine with anti-alcoholic effect, there is no report

Method used

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  • Application of shayacha extract in preparation of anti-alcohol product
  • Application of shayacha extract in preparation of anti-alcohol product
  • Application of shayacha extract in preparation of anti-alcohol product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Shiya tea extract

[0021] Put Shiya tea in a constant temperature drying oven at 60°C for 4 hours, pulverize it with a traditional Chinese medicine grinder, and pass through an 80-mesh sieve to obtain Shiya tea powder. Weigh Shiya tea powder and add 70% ethanol solution with a solid-liquid ratio of 1:20, gently shake the conical flask with stopper, so that the powder in the conical flask with stopper is evenly dissolved in the ethanol solution, and then in 80 Under the temperature of ℃, ultrasonic assisted extraction for 30min, after the first extraction, the obtained extract was centrifuged at 3000r / min for 10min, the supernatant was collected, and the filter residue was added with 70% ethanol at a solid-liquid ratio of 1:10 The solution was subjected to the second ultrasonic extraction at 80°C for 30 minutes. At this time, the obtained extract was centrifuged, the filter residue was discarded, and the obtained supernatant was combined...

Embodiment 2

[0022] Example 2 The Behavioral Effects of Shiya Tea Extract on Drunken Mice

[0023] 50 male Kunming mice were randomly divided into 5 groups according to body weight, namely: blank control group, drunken model control group, low-dose Shiya tea extract group, medium-dose Shiya tea extract group, high-dose Shiya tea extract group, and high-dose Shiya tea extract group. Tea extract group, 10 rats in each group. Food and water were fasted overnight (12h) before the experiment. Blank control group mice were fed with 10mL / (kg bw) of distilled water; model group mice and low, medium and high dose groups of Shiya tea extract were fed with 50% of 10mL / (kg bw) ( V / V) Ethanol. After 30 minutes, the mice in the blank control group and the mice in the model group were fed with 12mL / (kg bw) of distilled water; (kg·bw)) were intragastrically administered low, medium and high doses of Shiya tea extract. Conduct behavioral experiments on them, which are divided into two parts: righting r...

Embodiment 3

[0029] Example 3 The effect of Shiya tea extract on the activation of alcohol dehydrogenase and acetaldehyde dehydrogenase in vitro (in vitro experiment)

[0030] The activity of alcohol dehydrogenase was determined by the modified Valle&Hoch method. 1.5mL 32mM sodium pyrophosphate buffer (pH8.8), 1.0mL 27mM NAD + Solution, 0.5mL 11.5% (v / v) ethanol, 0.1mL 30mg / mL Shiya tea extract, mix well, after incubating at 25°C for 5min, immediately add 0.1mL ADH (0.64μg / mL) solution. In the control group, 0.1 mL of distilled water was used instead of the Shiya tea extract solution, and the rest of the operations were the same. Immediately at a wavelength of 340nm, read once every 10s, and measure continuously for 5min. Alcohol dehydrogenase activity calculation method plots A against time, and calculates A 340 / 10s increase value, according to the molar extinction coefficient of NADH at 340nm is 6.22, calculate the enzyme activity. The activity of ADH is expressed in nanomoles of NA...

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Abstract

The invention discloses application of a shayacha extract in the preparation of an anti-alcohol product, in particular to the application of the shayacha extract as an anti-alcohol active substance inthe preparation of a drug, food or health care product with an anti-alcohol effect. After the shayacha extract is applied to a drunken mouse, the concentration of ethanol in the blood of the drunkenmouse is significantly reduced and the sober-up time is shortened; at the same time, the incubation period and climbing time for intoxication of the mouse are significantly prolonged, and the ethanoldehydrogenase activity and the acetaldehyde dehydrogenase activity in the liver of the body are improved, as a result, ethanol can be effectively metabolized to acetaldehyde in the liver of the body,acetaldehyde can be metabolized to acetic acid, and finally acetic acid can be converted into carbon dioxide and water, and excreted from the body, thereby effectively relieving alcoholism and gettingrid of a drunk state. Therefore, the shayacha extract can be used for preparing the drug, food or health care product with the anti-alcohol effect.

Description

technical field [0001] The invention relates to the technical fields of medical technology and health products, and more specifically, relates to the application of Shiya tea extract in the preparation of hangover-relief products. Background technique [0002] "Wine culture" is an important part of the food culture of the Chinese nation, and long-term excessive drinking has great harm to the human body. For example, the intake of alcohol and its toxic metabolite acetaldehyde can indirectly or directly cause fatty liver, cirrhosis, Blood sugar, hyperlipidemia, damage to the central nervous system and other diseases. Therefore, seeking effective hangover agent is one of hot spots that people pay close attention to for a long time. [0003] Adinandra nitida, also known as Adinandra nitida, is a plant of the genus Yangtong in the family Theaceae. Among them, the total flavonoid content is very rich, generally as high as 20%, much higher than other teas; and its caffeine conten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P39/02A23L33/105
CPCA23V2002/00A61K36/82A23L33/105A61P39/02A23V2200/334A23V2250/21
Inventor 孙远明李郡李美英谌国莲
Owner 广州华农大营养科技有限公司
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