Unlock instant, AI-driven research and patent intelligence for your innovation.

Specific molecular probe for breast cancer MR-fluorescent bimodal imaging combined photo-thermal therapy

A technology of photothermal therapy and molecular probes, applied to diseases, drug combinations, preparations for in vivo tests, etc.

Inactive Publication Date: 2019-02-15
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, this multifunctional nanoprobe has not been shown in preclinical studies in HER-2-positive breast cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Specific molecular probe for breast cancer MR-fluorescent bimodal imaging combined photo-thermal therapy
  • Specific molecular probe for breast cancer MR-fluorescent bimodal imaging combined photo-thermal therapy
  • Specific molecular probe for breast cancer MR-fluorescent bimodal imaging combined photo-thermal therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Such as Figure 1-2 As shown, a specific molecular probe for breast cancer MR-fluorescence dual-modal imaging combined with photothermal therapy, including superparamagnetic iron oxide carrier, monoclonal anti-human epidermal growth factor receptor 2 (HER-2) Antibody—trastuzumab 3 and fluorescent molecule 4, the superparamagnetic iron oxide carrier is PEGylated superparamagnetic iron oxide nanoparticles, including Fe 3 o 4 Inner core 1 and DSPE-PEG2000 molecular coating layer 2, the superparamagnetic iron oxide carrier is directly connected to the amino group of trastuzumab 3, and the terminal carboxyl group of the fluorescent molecule 4 is combined with the amino group of trastuzumab 3, so The fluorescent molecule 4 is indocyanine green ICG-Sulfo-OSu.

[0030] Such as image 3 As shown, the specific molecular probes for breast cancer MR-fluorescence dual-modal imaging combined with photothermal therapy were prepared by the following steps:

[0031] (1) Coating DSPE...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a specific molecular probe for breast cancer MR-fluorescent bimodal imaging combined photo-thermal therapy. The specific molecular probe comprises a superparamagnetic iron oxide carrier, trastuzumab and a fluorescent molecule, wherein the superparamagnetic iron oxide carrier is PEG superparamagnetic iron oxide nanoparticles and is directly connected to the amino group of the trastuzumab, and the terminal carboxyl group of the fluorescent molecule is bonded with the amino group of the trastuzumab. The specific molecular probe for breast cancer MR-fluorescent bimodal imaging combined photo-thermal therapy can be used for MR-fluorescent bimodal imaging combined photo-thermal therapy of breast cancer living bodies.

Description

technical field [0001] The invention relates to the field of medical and health technologies, in particular to a specific molecular probe for breast cancer MR-fluorescence dual-modal imaging combined with photothermal therapy. Background technique [0002] Magnetic resonance examination has the characteristics of high soft tissue resolution, no ionizing radiation, and the ability to provide multi-parameter, multi-contrast images. It has become the most important examination method for clinical imaging examination of breast cancer. Optical imaging has the advantages of no radioactive radiation and reproducible detection, and has been widely used in molecular imaging. Some studies have used fluorescence imaging to qualitatively and quantitatively detect the expression of HER-2 receptors in breast cancer. However, fluorescence imaging also has the disadvantages of low resolution and poor tissue penetration. The emergence of multimodal nanoprobes has enabled the fusion of MRI a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K49/12A61K49/16A61K49/00A61K41/00A61P35/00A61P15/14
CPCA61K41/0052A61K49/0034A61K49/0054A61K49/0058A61K49/126A61K49/16A61P15/14A61P35/00
Inventor 洛小珺
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI