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Medicinal use of extract of chu-lan tree flower or leaf against ischemic stroke

A technology of extract and celery, applied in the field of medicinal use of celiac extract for anti-ischemic cerebral apoplexy

Active Publication Date: 2019-02-19
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the research of modern medicine, the current reports on the pharmacological activities of Mizalan plants mainly focus on anti-inflammatory and immune regulation, anti-virus, anti-tumor and other activities, and there are no reports on neuroprotection.

Method used

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  • Medicinal use of extract of chu-lan tree flower or leaf against ischemic stroke
  • Medicinal use of extract of chu-lan tree flower or leaf against ischemic stroke
  • Medicinal use of extract of chu-lan tree flower or leaf against ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of miza orchid leaf extract

[0026] Take 200g of mizilan leaves and grind them with a pulverizer. Ultrasonic extraction with 8 times the amount of 95% ethanol was performed 3 times, 1 hour each time. The solvent was recovered from the extract under reduced pressure to obtain a 95% ethanol extract, and after the solvent was completely evaporated until there was no alcohol smell, 5 g of the extract of Mizilan leaves was obtained.

Embodiment 2

[0027] Example 2 Protective effect of miza orchid leaf extract on cerebral ischemia-reperfusion injury in rats

[0028] 2.1 Test animals: SD rats, 8 weeks old, male, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0029] 2.2 Test drugs:

[0030] Mizilan leaf extract is dissolved in 0.5% CMCNa solution to prepare a 5 mg / mL drug solution.

[0031] 2.3 Grouping and handling of animals:

[0032] 24 SD rats were fed adaptively for 1 week, 8 in each group, and randomly divided into 3 groups: sham group (sham operation group, only cut the epidermis but not arterial ligation), model group (normal saline 300ml / kg ), mizalan leaf extract group (300mg / kg). Both the model group and the mizalan leaf extract group underwent the following operations:

[0033] The right common carotid artery (CCA), internal carotid artery (ICA) and external carotid artery (ECA) were isolated from SD rats, the ECA was ligated and cut off, and the CCA was temporarily blocked with a silk t...

Embodiment 3

[0044] Example 3 Improvement of neuroethology induced by cerebral ischemia-reperfusion in rats with miza orchid leaf extract

[0045] 3.1 Test animals: SD rats, 8 weeks old, male, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0046] 3.2 Test drugs:

[0047] Mizilan leaf extract is dissolved in 0.5% CMCNa solution to prepare a 5 mg / mL drug solution.

[0048] 3.3 Grouping and handling of animals:

[0049] 24 SD rats were fed adaptively for 1 week, 8 in each group, and randomly divided into 3 groups: sham group (sham operation group, only cut the epidermis but not arterial ligation), model group (normal saline 300ml / kg ), mizalan leaf extract group (300mg / kg). The animals in the model group and the mizalan leaf extract group were all subjected to the following operations:

[0050] The right common carotid artery (CCA), internal carotid artery (ICA) and external carotid artery (ECA) were isolated from SD rats, the ECA was ligated and cut off, and the CCA w...

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Abstract

The invention relates to a new medical use of the extract of chu-lan tree flower or leaf, in particular to the use of the extract of chu-lan tree flower or leaf in the preparation of drugs for treating ischemic stroke. The invention also provides the use of the extract of chu-lan tree flower or leaf in the preparation of drugs for prevention and / or treatment of acute and chronic complications caused by ischemic stroke.

Description

technical field [0001] The present invention relates to the medical use of mizilan extract, in particular to the application of mizilan extract in the preparation of neuroprotective drugs, in particular to the application of mizilan in the preparation of anti-ischemic stroke drugs, and the The medicine of zilan extract. Background technique [0002] Ischemic stroke, also known as apoplexy, is acute neuronal necrosis induced by decreased cerebral blood perfusion. Therefore, ischemic stroke has become the neurological disease with the highest disability rate. How to improve the cranial nerve damage caused by ischemic stroke has always been the goal pursued by the medical community. At present, a variety of neuroprotective agents are used clinically, including edaravone, gangliosides, cerebroside carnosine, butylphthalide, etc. , but their efficacy and safety need to be further verified, and there is still an urgent need to develop new neuroprotective agents for improving bra...

Claims

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Application Information

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IPC IPC(8): A61K36/58A61P9/10A61P25/28A61P25/16A61P25/00A61P27/02A61P21/00A23L33/105A61K127/00
CPCA23V2002/00A61K36/58A61K2236/15A61K2236/333A61K2236/39A61K2236/51A23L33/105A61P9/10A61P21/00A61P25/00A61P25/16A61P25/28A61P27/02A23V2250/21A23V2200/322
Inventor 曾克武姜勇屠鹏飞王竞康
Owner PEKING UNIV