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A dry suspension of tofu fruit glycosides for preventing and treating ischemic cardiovascular and cerebrovascular diseases, its preparation method and application

A technique for cardiovascular and cerebrovascular diseases and dried tofu fructose, which is applied in the field of medicine and can solve problems such as no research reports on cardiovascular and cerebrovascular diseases.

Active Publication Date: 2017-03-08
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical application of tofu glucoside in the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases has not yet been reported

Method used

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  • A dry suspension of tofu fruit glycosides for preventing and treating ischemic cardiovascular and cerebrovascular diseases, its preparation method and application
  • A dry suspension of tofu fruit glycosides for preventing and treating ischemic cardiovascular and cerebrovascular diseases, its preparation method and application
  • A dry suspension of tofu fruit glycosides for preventing and treating ischemic cardiovascular and cerebrovascular diseases, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Tofu fruit glycosides dry suspension

[0031] Prescription composition:

[0032] Tofu fruit glycosides 1000g

[0033] Microcrystalline Cellulose 2000g

[0034] Povidone 200g

[0035] Micronized silica gel 200g

[0036] Magnesium Stearate 100g

[0037] Flavor 50g

[0038] Add lactose to 5000g

[0039] According to the amount of the above components, take tofu fruit glycosides and grind them through a 120-mesh sieve, dry and pulverize other auxiliary materials except the flavoring agent respectively and pass through a 100-mesh sieve. Lactose is mixed evenly, then micronized silica gel, magnesium stearate and flavoring agent are added and mixed well to form a solid powder, which is divided into single doses to make 1000 bags in total, each weighing 5g, containing 1g tofu glucoside.

Embodiment 2

[0041] Tofu fruit glycosides dry suspension

[0042] Prescription composition:

[0043] Tofu fruit glycosides 200g

[0044] Hydroxypropyl Methyl Cellulose 1000g

[0045] Sodium Carboxymethyl Cellulose 100g

[0046] Magnesium Stearate 50g

[0047] Flavor 50g

[0048] Add mannitol to 2000g

[0049] According to the amount of the above components, take tofu fruit glycosides and grind them through a 120-mesh sieve, dry and pulverize other auxiliary materials except the flavoring agent respectively and pass through a 100-mesh sieve, and use an equal-amount incremental method to mix the dried tofu fruit with hydroxypropyl methylcellulose and carboxylate. Sodium methylcellulose and mannitol are mixed evenly, then magnesium stearate and flavoring agent are added and mixed thoroughly to form a solid powder, which is divided into single doses to make 1000 bags in total, each bag weighing 2g, which contains tofu glucoside 0.2g.

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Abstract

The invention discloses a hilicidum dry suspension for preventing and treating ischemic cardiovascular and cerebrovascular diseases as well as a preparation method and application thereof. The dry suspension comprises 20-2000 parts of hilicidum, 20-2000 parts of filling agent, 20-200 parts of suspending aid, 20-100 parts of flow aid, 20-100 parts of lubricating agent, 1-50 parts of surfactant and 1-50 parts of flavouring agent by weight. The preparation method is characterized by comprising the following steps: grinding the hilicidum, then sieving the ground hilicidum with a 120-mesh sieve, respectively drying and grinding the auxiliary materials except the flavouring agent, sieving the ground materials with a 100-mesh sieve, uniformly mixing the hilicidum with the filling agent and the suspending aid by an equivalent gradual increase method, then adding the flow aid, the lubricating agent and the flavouring agent and fully mixing the materials uniformly to obtain solid powder, thus obtaining the target preparation. The hilicidum dry suspension is applied to medicaments for preventing and / or treating ischemic cardiovascular and cerebrovascular diseases. The hilicidum in the hilicidum dry suspension can obviously reduce the volume of global cerebral ischemic and focal ischemic cerebral infarction and is used for preventing and treating ischemic cerebral infarction.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a dry suspension of bean curd fruit glycosides for preventing and treating ischemic cardiovascular and cerebrovascular diseases, a preparation method and application thereof. Background technique [0002] Ischemic cardiovascular and cerebrovascular diseases are one of the most important diseases leading to death and disability in modern society. In particular, China has become a high-incidence area for ischemic cardiovascular and cerebrovascular diseases. This disease is a series of heart or brain tissue damage caused by ischemia and hypoxia in the corresponding area of ​​the heart or brain tissue caused by heart and / or brain blood supply disorders. Diseases such as abnormal biochemical metabolism, loss of physiological functions, and softening and changing of patient morphology are diseases that damage the heart and brain tissue at multiple levels and in many ways. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/7034A61P9/10
Inventor 张伟杨兆祥刘一丹
Owner KPC PHARM INC