Application of hyperoside and cerebral ischemia-reperfusion injury treatment medicine
A technology of cerebral ischemia reperfusion and hyperin, which is applied in the field of medicine to achieve the effect of reducing the ischemic area of brain tissue, reducing the apoptosis of nerve cells, and reducing the ischemic area of brain tissue
Pending Publication Date: 2022-01-21
肖瑞
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Whether hyperoside can reduce the apoptosis caused by cerebral ischemia / reperfusion injury by regulating the Bnip3 apoptosis pathway, and it can be used for the treatment of cerebral ischemia-reperfusion injury diseases, there is no research report
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[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.
[0023] Experimental materials: SD rats were selected for animal experiments; hyperin, purity >98%, structural formula:
[0024]
[0025] The SD rat cerebral ischemia (Ischemia-I) / reperfusion (Reperfusion-R) injury model was established. The rat model adopts the modeling method described in the modified Nagasawa method: the animal is anesthetized with ip 7% chloral hydrate (350 mg / kg). A median neck incision was made, and the right common caroti...
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The invention provides application of hyperoside and a cerebral ischemia reperfusion injury treatment medicine. The method comprises the following steps: establishing an SD rat brain ischemia / reperfusion injury model, observing the activity of peroxide dismutase (SOD), the content of malondialdehyde (MDA), carrying out morphological observation on brain tissue cells, observing the infarct area of brain tissues by TTC staining, observing neuronal lesions of hippocampus CA1 regions of the brain tissues by HE staining, detecting the expression levels of Bnip3 proteins and genes by Western-blot and RT-PCR, and detecting the regulation and control conditions of Hyp on the Bnip3 proteins and genes. The results prove that the hyperoside has a protective effect on the cerebral ischemia reperfusion injury, can reduce the ischemic area of the cerebral tissue of the cerebral ischemia reperfusion injury, can reduce the ischemic area of the cerebral tissue during cerebral ischemia reperfusion by blocking a Bnip3 apoptosis pathway, reduces nerve cell apoptosis caused by the cerebral ischemia reperfusion injury, and can be used for treating the cerebral ischemia reperfusion injury. The compound can be used for preparing a therapeutic drug for resisting cerebral ischemia-reperfusion injury.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to the use of hyperin and a drug for treating cerebral ischemia-reperfusion injury. Background technique [0002] Ischemic stroke is the main clinical type of cerebrovascular disease, which is a sudden brain blood circulation disorder disease, manifested as a clinicopathological process of local brain tissue hypoxia, ischemia and nerve necrosis. The treatment of ischemic stroke is often to use thrombolysis or interventional therapy in the early stage of onset to recanalize the blocked blood vessel early and restore blood supply, so as to minimize the loss of neurological function; however, serious consequences caused by reperfusion injury such as oxidative stress Injury and cell apoptosis will bring serious adverse consequences, often aggravating the loss of neurological function, leading to serious sequelae such as limb hemiplegia, which will bring serious manpower and material re...
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IPC IPC(8): A61K31/7048A61P9/10A61K36/38
CPCA61K31/7048A61P9/10A61K36/38
Inventor 肖瑞向安莉郑莉黄敏黄芳郭琳夏丽秀易在凤赖星
Owner 肖瑞