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Application of anthraquinone dimer derived from Cordyceps sinensis in the preparation of drugs for the treatment of primary lung cancer

An anthraquinone dimer, primary technology, applied in the field of natural medicine, can solve the problems of no relevant reports in the literature, and achieve the effect of inhibiting growth and cloning formation ability

Active Publication Date: 2020-02-14
广州金蝉花科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cicadaquinone, an anthraquinone dimer, belongs to anthraquinone compounds. It is a new type of organic drug molecule with anti-tumor activity found in the fungus Cordyceps cicadae. There is no relevant report in the literature.

Method used

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  • Application of anthraquinone dimer derived from Cordyceps sinensis in the preparation of drugs for the treatment of primary lung cancer
  • Application of anthraquinone dimer derived from Cordyceps sinensis in the preparation of drugs for the treatment of primary lung cancer
  • Application of anthraquinone dimer derived from Cordyceps sinensis in the preparation of drugs for the treatment of primary lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Carry out cytotoxic activity experiment on anthraquinone dimer Cicadaquinone

[0016] 1. Materials:

[0017] 1.1 Tetrazole compound (MTS):

[0018] (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, CellTiter 96 Aqueous One Solution Reagent, Promega, USA).

[0019] 1.2 Preparation of target cells: recovery and culture of human breast cancer cell line MDA-MB-435, human liver cancer cell line HepG2, human colon cancer cell line HCT116 and human lung cancer cell line H460.

[0020] a. Take out the cryopreservation tubes of human breast cancer cell line MDA-MB-435, human liver cancer cell line HepG2, human colon cancer cell line HCT116, human lung cancer cell line H460 and human normal cell MCF10A from the liquid nitrogen tank, and quickly put them into In a 37°C water bath, shake continuously to dissolve it quickly, and transfer it into a centrifuge tube aseptically;

[0021] b. Add DMEM complete culture solution to 10mL...

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Abstract

The invention discloses the application of anthraquinone dimer derived from Cordyceps sinensis in the preparation of medicine for treating primary lung cancer. The invention discloses for the first time the use of anthraquinone dimer Cicadaquinone in the preparation of drugs for the treatment of primary lung cancer, which can effectively inhibit the growth and clone formation ability of lung cancer cell lines, and the compound is derived from natural drug resources and has low toxicity , high-efficiency characteristics, providing a new choice and thinking for the current primary lung cancer drugs.

Description

technical field [0001] The invention relates to the application of anthraquinone dimer Cicadaquinone, in particular to the application of anthraquinone dimer Cicadaquinone in the preparation of drugs for treating primary lung cancer, which belongs to the field of natural medicines. Background technique [0002] Currently, the treatment methods for lung cancer mainly include surgery, arterial chemoembolization, local radiofrequency ablation, and biological therapy. How to consolidate the effect of interventional therapy, delay tumor recurrence, reduce metastasis, and prolong the survival of patients is the difficulty of current treatment. Therefore, it is of great significance to seek drugs with low toxicity, high efficiency and strong selectivity for the treatment of primary lung cancer. [0003] Cicadaquinone, an anthraquinone dimer, belongs to anthraquinone compounds. It is a new type of organic drug molecule with anti-tumor activity found in the fungus Cordyceps cicadae....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K31/337A61P35/00
CPCA61K31/122A61K31/337A61K36/068A61P35/00A61K2300/00
Inventor 佘志刚潘亚宏黄锡山梅秀丽李闯彪
Owner 广州金蝉花科技有限公司