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New application of geraniol, preparation for preventing and treating pruritus not caused by disease, and method

A technology of geraniol and preparations, which is applied in the field of biomedicine, can solve the problems of geraniol's antipruritic antipruritic mechanism, no direct relationship between geraniol and no high-efficiency drugs for itching, etc., so as to prevent skin itching effect

Inactive Publication Date: 2019-03-22
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent only uses geraniol in the compounded Chinese herbal medicine, but the effect of geraniol and the antipruritic mechanism of antipruritic toilet water are not clear
[0009] In summary, the prior art has not disclosed the direct relationship between geraniol and pruritus, and there is no highly effective drug for pruritus

Method used

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  • New application of geraniol, preparation for preventing and treating pruritus not caused by disease, and method
  • New application of geraniol, preparation for preventing and treating pruritus not caused by disease, and method
  • New application of geraniol, preparation for preventing and treating pruritus not caused by disease, and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 prepares antipruritic pharmaceutical composition

[0032] Geraniol was dissolved in corn oil and administered in four different gradients, wherein the dosage of geraniol was 25 mg / kg, 50 mg / kg, 100 mg / kg, and 200 mg / kg.

Embodiment 2

[0033] Example 2 Geraniol is used for the treatment of histamine-dependent pruritus

[0034] 1. Main experimental animals and reagents

[0035] Mice: SPF grade male C57BL / 6 mice used in this experiment, 8-10 weeks old, weighing 16-20 g (Shanghai Slack Experimental Animal Co., Ltd.). The feeding conditions are clean level, 5-6 birds / cage, free water supply. The experimental animals were divided into groups by completely random method.

[0036] Reagents: corn oil, the antipruritic pharmaceutical composition prepared in Example 1, compound 48 / 80 (synthesis of 48 / 80, product number C2313).

[0037] 2. Method for establishing a histamine-dependent pruritus model

[0038] Male C57BL / 6 mice were selected, and the compound 48 / 80 was injected intradermally on the back of the neck, and the mice showed significant scratching behavior within 30 minutes after modeling.

[0039] 3. Experimental method

[0040] Experimental group: Intraperitoneal injection of different doses of geraniol...

Embodiment 3

[0046] Example 3 Geraniol is used to treat non-histamine-dependent pruritus experiment

[0047]1. Main experimental animals and reagents

[0048] Mice: SPF grade male C57BL / 6 mice used in this experiment, 8-10 weeks old, weighing 16-20 g (Shanghai Slack Experimental Animal Co., Ltd.). The feeding conditions are clean level, 5-6 birds / cage, free water supply. The experimental animals were divided into groups by completely random method.

[0049] Reagents: corn oil, the antipruritic pharmaceutical composition prepared in Example 1, 200ug / 50ul chloroquine (Chloroquine, CQ, product number C6628).

[0050] 2. Establishment of non-histamine-dependent pruritus model

[0051] Male C57BL / 6 mice were selected and intradermally injected with chloroquine on the back of the neck. The mice showed significant scratching behavior within 30 minutes after modeling.

[0052] 3. Administration

[0053] Experimental group: geraniol (25, 50, 100, 200 mg / kg) at different doses were injected int...

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Abstract

The invention discloses geraniol or application of pharmaceutically acceptable ingredients thereof for preparing a medicine composition for preventing and treating pruritus, and a method for preventing and treating pruritus not caused by disease. The medicine composition or a preparation provided by the invention is used for performing individual administration. The invention provides the geraniolor the application of pharmaceutically acceptable ingredients thereof for preparing the medicine composition for preventing and treating pruritus, the preparation for preventing and treating pruritus, and the method.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a new application of geraniol, a preparation and a method for preventing and treating non-disease-induced pruritus. Background technique [0002] Pruritus is a common unpleasant sensation often accompanied by scratching. It is the main symptom of many systemic diseases and skin diseases, which can seriously affect the physical and mental health of patients and reduce the quality of life. Acute pruritus is mostly caused by kidney and biliary diseases and side effects of drugs, while chronic and severe pruritus often occurs in skin diseases such as atopic dermatitis in addition to the above diseases. Pruritus can be directly caused by chemical mediators of the skin, or it can be caused by changes in physical factors (such as temperature), which in turn can cause reactions in peripheral nerve fibers or even the central nervous system. [0003] The generation of pruritus is the result of ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P17/04
CPCA61K31/045A61P17/04
Inventor 米文丽杜利霞乔铮朱健瑜王彦青
Owner FUDAN UNIV
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