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A bone repair scaffold that simultaneously releases zinc ions and strontium ions and its preparation method

A technology of strontium ions and zinc ions, applied in the field of bone repair scaffolds that simultaneously release zinc ions and strontium ions and its preparation, can solve problems such as the gap in the bionic level of comprehensive performance of materials, achieve improved degradation performance, high mechanical strength, and promote growth bone effect

Active Publication Date: 2021-07-16
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, research has been devoted to the development and preparation of collagen-based or biomaterials that use it as an additive phase for bone tissue repair, but the comprehensive performance and bionic degree of the obtained materials are still far from the application requirements.

Method used

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  • A bone repair scaffold that simultaneously releases zinc ions and strontium ions and its preparation method
  • A bone repair scaffold that simultaneously releases zinc ions and strontium ions and its preparation method
  • A bone repair scaffold that simultaneously releases zinc ions and strontium ions and its preparation method

Examples

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preparation example Construction

[0037] The preparation method of strontium-doped octacalcium phosphate of the present invention is:

[0038] (1) prepare the mixed solution containing calcium nitrate and strontium acetate;

[0039] (2) prepare ammonium dihydrogen phosphate and urea solution;

[0040] (3) Add the mixed solution in step (1) dropwise to the ammonium dihydrogen phosphate and urea solution in step (2), stir for 2-4 hours at 70-90°C, wash and dry to obtain the obtained strontium-doped octacalcium phosphate.

[0041] The preparation method of zinc-doped hydroxyapatite of the present invention is:

[0042] (a) dissolving zinc nitrate and calcium nitrate in water to obtain a calcium-zinc solution;

[0043] (b) dissolving diammonium hydrogen phosphate in water, adjusting the pH value to 10-12 to obtain a diammonium hydrogen phosphate solution;

[0044] (c) Add the diammonium hydrogen phosphate solution dropwise to the calcium zinc solution, react at 70-90°C for 3-4 hours, keep the pH value of the s...

Embodiment 1

[0046] As an embodiment of the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions in the present invention, the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions described in this embodiment includes the following steps:

[0047](1) Mix and grind zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate in a mass ratio of 80:5:15 to obtain a solid phase powder, wherein the degree of substitution of strontium of strontium-doped octacalcium phosphate 10 mol%, the zinc substitution degree of zinc-doped hydroxyapatite is 5 mol%, and the particle diameters of zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate are 50-200 μm;

[0048] (2) carboxymethyl chitosan and collagen are dissolved in citric acid solution, stir evenly, obtain mixed solution, wherein, the massfraction of carboxymethyl chitosan is 1%, the mass r...

Embodiment 2

[0054] As an embodiment of the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions according to the present invention, the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions described in this embodiment includes the following steps:

[0055] (1) Mix and grind zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate in a mass ratio of 82:8:10 to obtain a solid phase powder, wherein the degree of substitution of strontium of strontium-doped octacalcium phosphate 10 mol%, the zinc substitution degree of zinc-doped hydroxyapatite is 5 mol%, and the particle diameters of zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate are 50-200 μm;

[0056] (2) carboxymethyl chitosan and collagen are dissolved in citric acid solution, stir evenly, obtain mixed solution, wherein, the massfraction of carboxymethyl chitosan is 1%,...

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Abstract

The invention discloses a bone repair support capable of simultaneously releasing zinc ions and strontium ions and a preparation method thereof. In the present invention, the solid phase powder is mixed with carboxymethyl chitosan and collagen solution, frozen to form oriented ice crystals, and finally the ice crystals are sublimated under the action of freeze-drying. Pores, and the connectivity of the porous structure is high. In the scaffold of the present invention, zinc-doped hydroxyapatite is used as the zinc source, strontium-doped octacalcium phosphate is used as the strontium source, and calcium silicate is used as the silicon source. Due to the different degradation rates of the materials, zinc ions, strontium ions and silicon ions are With different release rates, by adjusting the content of zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate, the degradation performance of the scaffold can be further improved and osteogenesis can be promoted. The bracket of the invention will have a good application prospect as a biomedical material in the fields of bone tissue repair and the like.

Description

technical field [0001] The invention relates to the technical field of bone repair materials, in particular to a bone repair support capable of simultaneously releasing zinc ions and strontium ions and a preparation method thereof. Background technique [0002] Bone is an important tissue of the human body. Although it has bone regeneration and self-repair capabilities, for bone defects caused by tumors, trauma, and abnormal bone growth, in the case that bone self-repair alone cannot heal, it is necessary to use implant materials to assist the damage. Tissue repair and healing. From the perspective of bone tissue self-healing, an ideal bone repair scaffold needs to have good biocompatibility, biodegradability, three-dimensional porous structure, and a complex shape that matches the defect site. [0003] The porous bone repair scaffold has a high specific surface area and space, which is conducive to the loading of active factors, cell adhesion and growth, deposition of extr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/54A61L27/50A61L27/20A61L27/24A61L27/12A61L27/02
CPCA61L27/025A61L27/12A61L27/20A61L27/24A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2300/45A61L2300/604A61L2430/02C08L5/08
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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