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Application of traditional Chinese medicine composition to preparation of medicines for preventing and treating chronic renal anemia

A technology of renal anemia and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of chronic renal anemia, which can solve the problems of long course of disease and increased burden on the liver, and achieve the improvement of immune function without hepatotoxicity Side effects, effects of enhancing regulation

Inactive Publication Date: 2019-03-29
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with chronic renal anemia need to take medicine for a long time due to the long course of the disease, but long-term use of most medicines will increase the burden on the liver

Method used

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  • Application of traditional Chinese medicine composition to preparation of medicines for preventing and treating chronic renal anemia
  • Application of traditional Chinese medicine composition to preparation of medicines for preventing and treating chronic renal anemia
  • Application of traditional Chinese medicine composition to preparation of medicines for preventing and treating chronic renal anemia

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preparation example Construction

[0028] Further, the preparation method of the Chinese medicine composition comprises the following steps:

[0029] (1) Crush Atractylodes macrocephala, 1 / 3 of yam, cardamom, rhubarb and roasted licorice into fine powder, set aside;

[0030] (2) Add astragalus, 2 / 3 yam, Cistanche cistanche and Salvia miltiorrhiza with 8 times the weight of water, decoct 2 times, decoct for 1 hour each time, filter the decoction, combine the filtrates, concentrate until the relative density is 1.2 clear ointment;

[0031] (3) Mix the fine powder obtained in step (1) with the clear paste obtained in step (2) to obtain a traditional Chinese medicine composition.

[0032] Further, the application of the traditional Chinese medicine composition in the preparation of medicine for treating renal anemia in rats.

[0033] Further, the application of the traditional Chinese medicine composition in the preparation of medicine for treating renal anemia in 5 / 6 nephrectomy rats.

[0034] The present inven...

Embodiment 1

[0042]Application of a traditional Chinese medicine composition in the preparation of medicines for preventing and treating chronic renal anemia, the traditional Chinese medicine composition is prepared from 450g of astragalus, 150g of Atractylodes macrocephala, 450g of Chinese yam, 150g of cistanche cistanche, 150g of cardamom, 225g of salvia miltiorrhiza, 150g of rhubarb and 90g of roasted licorice Form; Described preparation method comprises the following steps:

[0043] (1) Grind Atractylodes macrocephala 150g, yam 150g, cardamom 150g, rhubarb 150g and roasted licorice 90g into fine powder, set aside;

[0044] (2) Add 450g of Astragalus membranaceus, 300g of Chinese yam, 150g of cistanche cistanche and 225g of salvia miltiorrhiza, add 8 times the weight of water, decoct twice, 1 hour each time, filter the decoction, combine the filtrates, and concentrate at 60°C To a clear paste with a relative density of 1.2, cool to 25°C for later use;

[0045] (3) Mix the fine powder o...

Embodiment 2

[0048] The preparation method of the traditional Chinese medicine composition that is used for preventing and treating chronic renal anemia, described Chinese medicine composition is made of Radix Astragali 450g, Atractylodes macrocephala 150g, Chinese yam 450g, cistanche cistanche 150g, cardamom 150g, salvia miltiorrhiza 225g, rhubarb 150g and Radix Glycyrrhizae 90g; The preparation method comprises the following steps:

[0049] (1) Grind 150g Atractylodes macrocephala, 150g yam, 150g cardamom, 150g rhubarb and 90g roasted licorice into fine powder, set aside;

[0050] (2) Add 450g of Astragalus membranaceus, 300g of Chinese yam, 150g of cistanche cistanche and 225g of salvia miltiorrhiza, add 8 times the weight of water, decoct twice, 1 hour each time, filter the decoction, combine the filtrates, and concentrate at 60°C To a clear paste with a relative density of 1.2, cool to 25°C for later use;

[0051] (3) Mix the fine powder obtained in step (1) with the cooled clear pas...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition to preparation of medicines for preventing and treating chronic renal anemia, and belongs to the technical field oftraditional Chinese medicines. The traditional Chinese medicine composition can be applied to preparation of medicines for preventing and treating chronic renal anemia. After being applied to the medicines for preventing and treating chronic renal anemia, the traditional Chinese medicine composition can invigorate the spleen, nourish the kidney and improve anemia symptoms. The traditional Chinesemedicine composition cannot cause side effect of hepatotoxicity, and cannot aggravate the burden of livers of patients when being used for preventing and treating the chronic renal anemia. The invention further discloses a preparation method of the traditional Chinese medicine composition for preventing and treating chronic renal anemia. The traditional Chinese medicine composition is prepared through the following steps of crushing bighead atractylodes rhizomes, 1 / 3 of Chinese yams, cardamun, radix et rhizoma rhei and radix glycyrrhizae preparata to obtain fine powder for standby application; adding water to radix astragali, 2 / 3 of the Chinese yams, cistanche deserticola soaked in wine and radix salviae miltiorrhizae, wherein the weight of the added water is 8 times of that of componentsof the radix astragali, 2 / 3 of the Chinese yams, the cistanche deserticola soaked in wine and the radix salviae miltiorrhizae, performing decoction twice, wherein the time for decoction each time is1 hour, filtering filtrate obtained by decoction, merging the filtrate, and performing concentrating to obtain sugarless paste of which the relative density is 1.2; and uniformly mixing the fine powder with the sugarless paste.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and treating chronic renal anemia. Background technique [0002] The core feature of renal anemia is that the production of erythropoietin (EPO) is relatively insufficient, which affects the production of red blood cells. It is a common complication of chronic kidney disease (CKD). With the decline of renal function, the incidence of renal anemia gradually increases, and the degree of anemia gradually increases. Without early diagnosis and timely intervention, renal anemia will seriously affect the quality of life of CKD patients and increase the risk of death. At present, the clinical treatment of renal anemia is mainly based on the injection of erythropoiesis-stimulating agent (ESA) drugs, but due to the existence of adverse reactions s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P13/12A61P7/06
CPCA61K36/284A61K36/481A61K36/484A61K36/537A61K36/64A61K36/708A61K36/8945A61K36/9064A61K2236/331A61K2236/39A61K2236/51A61P7/06A61P13/12A61K2300/00
Inventor 陈剑平李顺民张尚斌刘新辉陈秋谷胡兆流王佛长黄诗莹祁爱蓉卢建东郑平
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL