Antibody coupling bismuth selenide nanometer particles for united treatment of tumor thermal treatment and immunotherapy and preparation method of antibody coupling bismuth selenide nanometer particles
A nanoparticle and antibody coupling technology, which is applied in the direction of antibodies, anti-tumor drugs, antibody medical components, etc., can solve problems such as anemia, and achieve the effects of enhanced phagocytosis, high photothermal conversion performance, and simple preparation process
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[0040] A method for preparing antibody-coupled bismuth selenide nanoparticles for photothermal therapy of tumors combined with immunotherapy, comprising the following steps:
[0041] In the first step, bismuth selenide nanoparticles (Bi 2 Se 3 )
[0042] 1.1) Accurately weigh 365mg of Bi(NO 3 ) 3 ·5H 2 O dissolved in 10mL 1mol / L NHO 3 solution and placed in a 100mL small beaker, then add 106mg of NaOH to the mixed solution to obtain a mixed solution. Add 1.2 g of polyvinylpyrrolidone (PVP) to 50 mL of ethylene glycol (EG) on a magnetic stirrer while stirring at a power of 1200 r / min, and then ultrasonicate the mixed solution for 5 min. Finally, the above two reaction solutions were mixed and transferred to a high-pressure reactor, and heated at 150° C. for 3 hours. The obtained reaction solution was washed three times with deionized water, and then dissolved in 10 mL of deionized water again for subsequent reaction.
[0043] 1.2) Mix 10mL of bismuth oxide solution with...
Embodiment 2
[0067] A method for preparing antibody-coupled bismuth selenide nanoparticles for photothermal therapy of tumors combined with immunotherapy, comprising the following steps:
[0068] In the first step, bismuth selenide nanoparticles (Bi 2 Se 3 )
[0069] 1.1) Accurately weigh 182mg of Bi(NO 3 ) 3 ·5H 2 O dissolved in 5 mL of 1mol / L NHO 3 solution and placed in a 100mL small beaker, then 80mg of NaOH was added to the mixed solution to obtain a mixed solution. Add 0.8 g of polyvinylpyrrolidone (PVP) to 25 mL of ethylene glycol (EG) on a magnetic stirrer while stirring at a power of 1500 r / min, and then ultrasonicate the mixed solution for 5 min. Finally, the above two reaction solutions were mixed and transferred to a high-pressure reactor, and heated at 130° C. for 3 hours. The obtained reaction solution was washed three times with deionized water, and dissolved in 5 mL of deionized water again for subsequent reaction.
[0070] 1.2) Mix 5mL of bismuth oxide solution wit...
Embodiment 3
[0080] A method for preparing antibody-coupled bismuth selenide nanoparticles for photothermal therapy of tumors combined with immunotherapy, comprising the following steps:
[0081] In the first step, bismuth selenide nanoparticles (Bi 2 Se 3 )
[0082] 1.1) Accurately weigh 728mg of Bi(NO 3 ) 3 ·5H 2 O dissolved in 20mL 1mol / L NHO 3 solution and placed in a 100mL small beaker, then add 320mg of NaOH to the mixed solution to obtain a mixed solution. 100mL of ethylene glycol (EG) was placed on a magnetic stirrer with stirring at a power of 1500r / min, and 1.8g of polyvinylpyrrolidone (PVP) was added, and then the mixed solution was sonicated for 5min. Finally, the above two reaction solutions were mixed and transferred to a high-pressure reactor, and heated at 180° C. for 5 hours. The obtained reaction solution was washed three times with deionized water, and dissolved in 20 mL of deionized water again for subsequent reaction.
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