SERS (Surface Enhanced Raman Scattering) substrate structure, preparation method and detection method

A detection method and substrate technology, which are applied in measurement devices, instruments, material analysis by optical means, etc., can solve the problem of difficult to effectively adapt to the substrate performance SERS substrate detection, etc., to achieve reuse, improve access capability, and improve SERS capability. Effect

Active Publication Date: 2019-04-02
NINGBO UNIV
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Problems solved by technology

[0005] In view of the shortcomings of the prior art described above, the object of the present invention is to provide a SERS substrate structure, preparation method and detection method, which are used to solve the problem of fixing the SERS substrate structure, fixing the SERS capability and the distance between nanoparticles in the prior art. Difficult to effectively adapt to substrate performance and detection of SERS substrates

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  • SERS (Surface Enhanced Raman Scattering) substrate structure, preparation method and detection method
  • SERS (Surface Enhanced Raman Scattering) substrate structure, preparation method and detection method
  • SERS (Surface Enhanced Raman Scattering) substrate structure, preparation method and detection method

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[0056] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0057] see Figure 1 to Figure 10 . It should be noted that the diagrams provided in this embodiment are only schematically illustrating the basic concept of the present invention, although only the components related to the present invention are shown in the diagrams rather than the number, shape and Dimensional drawing, the shape, quantity and proportion of each component can be changed arbitrarily during actual implementation, and...

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Abstract

The invention provides an SERS (Surface Enhanced Raman Scattering) substrate structure, a preparation method and a detection method. The SERS substrate structure comprises a base plate; a photosensitive structure layer and a nano-particle layer, wherein the photosensitive structure layer is located on the base plate; and the nano-particle layer is located on the photosensitive structure layer; thenanoparticle layer comprises a plurality of nano-particles, the nano-particles are subjected to spectral detection of a to-be-detected molecule under irradiation of a detection light wave. Through the above scheme, the variable structure of the SERS substrate is implemented through the design of the SERS substrate structure and the photosensitive structure layer, thereby realizing the variation of the SERS capability; the SERS capability can be improved under the condition of larger initial nanoparticle gaps through the design; the intrusion capability of the to-be-detected molecule and the SERS capability of the SERS substrate can be simultaneously improved, and the recycling of the SERS substrate can be also achieved.

Description

technical field [0001] The invention belongs to the technical field of molecular detection, and in particular relates to a SERS substrate structure, a preparation method and a detection method. Background technique [0002] Surface-enhanced Raman scattering (SERS) is a high-efficiency spectroscopic analysis technique with a sensitivity up to the single-molecule level. It has important application prospects in the fields of chemistry, environment, food and life sciences. For example, enhanced Raman spectroscopy can directly analyze water phase It is a non-destructive and non-contact detection technology for the structural state of biomolecules and a small amount of use. It has the characteristics of high efficiency, sensitivity, high cost performance, and convenient on-site rapid detection. Due to the long-range electromagnetic enhancement and short-range chemical enhancement, the SERS substrate can amplify the weak Raman (Raman) signal of the measured molecule (adsorbed on t...

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 王松帆顾辰杰王春燕王梦琦吴冠毅吕炜烽周灿梁
Owner NINGBO UNIV
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