Three-dimensional liquid chromatography separation system

A chromatographic separation and three-dimensional liquid phase technology, applied in the direction of material separation, analysis materials, measuring devices, etc., can solve the problems of inability to enrich the enrichment column and not exert the efficiency of the enrichment column, so as to reduce the total separation time and control the use Flexible, convenient and scalable effects

Pending Publication Date: 2019-04-02
李宜珊
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Problems solved by technology

However, this kind of system cannot use all the enrichment columns for the enrichment of components in the two-dimensional chromatographic separation mode, and the efficiency of all the enrichment columns has not been brought into play.

Method used

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  • Three-dimensional liquid chromatography separation system
  • Three-dimensional liquid chromatography separation system
  • Three-dimensional liquid chromatography separation system

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Embodiment

[0043] Embodiment A kind of three-dimensional high performance liquid chromatography separation system structure

[0044] In this embodiment, the enrichment column array A is a two-stage enrichment column array, and each enrichment column array has 9 enrichment columns, that is, the enrichment column array A has 18 enrichment columns, which are sequentially numbered as the enrichment column array The 1st enrichment column of A, the 2nd enrichment column, etc., the last number is the 18th enrichment column of enrichment column array A; the enrichment column array B has 9 enrichment columns, which are sequentially numbered as enrichment column The first enrichment column of column array B, the second enrichment column, etc., the last number is the ninth enrichment column of enrichment column array B; the liquid chromatography separation column array has 5 separation columns, which are numbered sequentially 1st separation column, 2nd separation column, etc., the last one is the 5...

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Abstract

The invention relates to a three-dimensional liquid chromatography separation system, comprising a high-performance liquid chromatography pump A, a high-performance liquid chromatography pump B, a gradient mixer A, a gradient mixer B, an injection valve, a two-position ten-way valve, a two-position six-way valve, an enrichment column array A, an enrichment column array B, a liquid chromatography separation column array, a detector, a diluent pump, a fraction collector and a connecting pipeline. According to the scheme of the invention, the two-position ten-way valve and the two-position six-way valve are used for switching multi-dimensional separation states, so that one-dimensional, two-dimensional or three-dimensional chromatography separation capabilities are realized. The three-dimensional liquid chromatography separation system has strong expansibility, and can be upgraded to a multi-dimensional liquid chromatography separation system only by reconnecting system pipelines on the premise of not increasing the system cost, so that the system has higher dimensional separation capabilities such as four-dimensional chromatography separation and the like; the system can also be taken as a common full three-dimensional liquid chromatography separation system by reconnecting the pipelines when necessary; and the system has a very broad application prospect in the separation and analysis of complex system samples with high separation difficulty.

Description

technical field [0001] The invention belongs to the technical field of high performance liquid chromatography separation and relates to a three-dimensional high performance liquid chromatography separation system. Background technique [0002] The limited resolution and peak capacity provided by ordinary one-dimensional chromatographic separation systems can hardly meet the requirements for the separation and analysis of all components of extremely complex system samples. Multidimensional chromatography technology can greatly improve the peak capacity and separation selectivity of the entire system, and has a unique and irreplaceable role in solving samples with complex components, uneven content, severe interference, and unknown components, and has quickly become a field of chromatography science research. one of the hotspots. [0003] There are three most common multidimensional liquid chromatography interface technologies: interface technology based on sample loop; inter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李宜珊
Owner 李宜珊
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