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Compound growth factor antimicrobial repair-promoting gel and preparation method and application thereof

A technology for compounding growth factors and growth factors, which is applied in the field of gels compounded with growth factors and their preparation, and can solve the problems of bacterial infection in the microenvironment of wounds and the like

Pending Publication Date: 2019-04-05
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the process of clinical wound repair, the wound microenvironment also faces the risk of various bacterial infections, etc.

Method used

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  • Compound growth factor antimicrobial repair-promoting gel and preparation method and application thereof
  • Compound growth factor antimicrobial repair-promoting gel and preparation method and application thereof
  • Compound growth factor antimicrobial repair-promoting gel and preparation method and application thereof

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Experimental program
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Embodiment approach

[0039] According to a preferred embodiment of the present invention, the gel further includes glycerin and a protein protecting agent.

[0040] In a further preferred embodiment, the protein protecting agent is mannitol.

[0041] Wherein, the function of the glycerin in the gel is a moisturizing agent and a solubilizing agent, and the function of the protein protection agent is to maintain the activity of growth factors.

[0042] According to a preferred embodiment of the present invention, based on 1000 parts by weight of the gel, the glycerol is used in an amount of 10-40 parts by weight.

[0043] In a further preferred embodiment, based on 1000 parts by weight of the gel, the glycerol is used in an amount of 20-40 parts by weight.

[0044] In a further preferred embodiment, based on 1000 parts by weight of the gel, the amount of glycerol is 30 parts by weight.

[0045] Wherein, the glycerin within this range not only makes the gel have better moisturizing effect, but also...

Embodiment 1

[0079] 0.5g chlorhexidine acetate is added in 900g water, obtains bacteriostat aqueous solution;

[0080] 20g carboxymethyl chitosan, 15g hydroxyethyl cellulose and 20g glycerin are added in the bacteriostat aqueous solution that step 1 obtains, stir, then carry out sterilization treatment (10KGy radiation sterilization), obtain gel matrix;

[0081] Add 15mg of human basic growth factor, 15mg of human intravascular epidermal growth factor and 10g of mannitol into 100g of water to dissolve, then filter and sterilize to obtain the active ingredient;

[0082] Under sterile conditions, the obtained gel matrix is ​​mixed with the active ingredient, stirred evenly, divided into aluminum tubes, and sealed to obtain the composite growth factor-promoting repair gel.

Embodiment 2

[0084] 0.7g chlorhexidine acetate is added in 900g water, obtains bacteriostat aqueous solution;

[0085] 30g carboxymethyl chitosan, 8g hydroxyethyl cellulose and 30g glycerin are added in the bacteriostat aqueous solution that step 1 obtains, stir, then carry out sterilization treatment (10KGy radiation sterilization), obtain gel matrix;

[0086] Add 10mg of human basic growth factor, 10mg of human intravascular epidermal growth factor and 7g of mannitol into 100g of water to dissolve, then filter and sterilize to obtain the active ingredient;

[0087] Under sterile conditions, the obtained gel matrix is ​​mixed with the active ingredient, stirred evenly, divided into aluminum tubes, and sealed to obtain the composite growth factor-promoting repair gel.

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Abstract

The invention discloses compound growth factor antimicrobial repair-promoting gel and a preparation method and application thereof. According to the compound growth factor antimicrobial repair-promoting gel, a compound gel substrate is formed by carboxymethyl chitosan, hydroxyethyl cellulose and sodium hyaluronate, then the compound gel substrate is internally loaded with human basic fibrolast growth factors and human vascular endothelial growth factors, thus combination of the growth factors and the gel substrate is achieved, and a wound surface repair microenvironment is constructed in a bionic mode so as to promote wound surface healing. The preparation method comprises the steps: the compound gel substrate is prepared firstly, then heparin sodium and mannitol are compounded with the growth factors to form active ingredients, finally, the compound gel substrate and the active ingredients are mixed to obtain the compound growth factor repair-promoting gel. The growth factors are compounded in the repair-promoting gel, the wound surface repair microenvironment is constructed in the bionic mode, meanwhile the significant antimicrobial function is further achieved, the microenvironment of the wound surface area is improved, healing of a wound and the wound surface is promoted, the wound surface healing rate is increased, and the wound surface healing time is shortened.

Description

technical field [0001] The invention belongs to the gel field, in particular to a gel compounded with growth factors, a preparation method and application thereof. Background technique [0002] Wound healing refers to a series of pathophysiological processes in which local tissues are repaired through regeneration, repair, and reconstruction after tissue defects are caused by trauma or other injuries. It is a dynamic, complex process that involves the extracellular matrix, kinases, various types of cells, and many other factors. Due to the complexity of pathological and physiological processes in wound healing, it is extremely difficult to completely achieve tissue regeneration. In addition, in the process of clinical wound repair, the wound microenvironment also faces the risk of various bacterial infections. Contents of the invention [0003] In order to overcome the above-mentioned problems, the present inventors have carried out intensive research, combined human bas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L26/008A61L2300/216A61L2300/252A61L2300/404A61L2300/414A61L2300/45C08L5/08C08L1/284
Inventor 肖健张宏宇许可孔晓霞吴疆李政懋赵应征
Owner WENZHOU MEDICAL UNIV