A microfluidic chip processing method based on an inserted capillary
A technology of microfluidic chips and processing methods, which is applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., and can solve problems such as poor transparency, observation of internal microchannels from the side of the chip, and large roughness of cutting sections. , to achieve the effect of cost saving, abundant sources and high transparency
Active Publication Date: 2021-03-30
BEIJING UNIV OF TECH
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Problems solved by technology
In the traditional droplet generation, due to the characteristics of the cured PDMS material, the cutting section of the blade and the PDMS model has a large roughness and poor transparency during the chip cutting process, and it is impossible to directly observe the internal microchannel from the side of the chip.
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[0036] 1. Processing requirements
[0037] a) The key link of the invention is to ensure the controllability of the capillary insertion position and the depth, in order to ensure that the capillary insertion microscope assisted by high speed or inverted microscope assisted in the capillary insertion, it is necessary to accurately adjust the capillary insertion depth and angle after the capillary insertion. It is guaranteed that the height error is not higher than 1 um and no more than 1 ° angle error, thereby ensuring accurate and controllable regulating the size, frequency and position of the droplets.
[0038]b) The existing microscope can only observe the droplets from the upper position of the droplets, and the surface of the entire droplet generation process is observed from the side. Sub-casting, the casting must completely cover the side to ensure that the side surface of the droplet generation process can be clearly observed.
[0039] c) To ensure that the droplets can be...
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Abstract
The invention discloses a micro-channel liquid drop three-dimensional generation method based on an inserted capillary tube. An existing generation mode of two-dimensional plane generation liquid drops is changed, only one main channel needs to be processed on the lower wall face of a PDMS microchip through a soft photoetching method, a side channel is provided with the capillary tube which is vertically inserted into the main channel, and the insertion position and depth are controllable; the position and depth of the capillary tube inserted into the micro-channel are changed, so that the liquid drops with different sizes and frequencies required by production are generated through the same PDMS channel. The technology can be applied to controllable liquid drop generation using the micro-channel technology and other related micro-channel three-dimensional flow visual research fields.
Description
Technical field [0001] The present invention relates to a new type of microfluidic chip, which can generate droplets of different sizes depending on different needs at the same location. The process belongs to the related three-dimensional flow field visualization of microchannel controlled liquid droplet generation technology. Background technique [0002] Microfluidic technology refers to the technical and science of controlling fluid flow, heat transfer, chemical reactions in micron-level mechanism, and is widely used in biological, chemical medicine, energy, aerospace and other fields. The technology is also characterized by fast generating rate, short reaction time, sufficient, no cross-contamination, and is 21st century emerging technology. In recent years, microfluidic technology at home and abroad has developed faster, and applied. Microfluidic core technology includes: Microchannel structure design and manufacturing, microbial scale fluid drive and control, microfluidic ...
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IPC IPC(8): B01L3/00
CPCB01L3/502707B01L2300/0832B01L2300/12
Inventor 申峰代建峰刘赵淼
Owner BEIJING UNIV OF TECH