Granules of traditional Chinese medicine composition for reducing blood fat and softening blood vessels and granulation method thereof

A technology for softening blood vessels and compositions, applied in the directions of drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., can solve the problems of large loss of active ingredients, difficulty in forming preparations, poor solubility, etc., and achieves small loss of active ingredients and improved Good medication compliance and solubility

Active Publication Date: 2019-04-16
CHANGCHUN RENMIN PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the original production process has the problems of difficult formulation molding, long production cycle, large loss of active ingredients, and poor solubility

Method used

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  • Granules of traditional Chinese medicine composition for reducing blood fat and softening blood vessels and granulation method thereof
  • Granules of traditional Chinese medicine composition for reducing blood fat and softening blood vessels and granulation method thereof
  • Granules of traditional Chinese medicine composition for reducing blood fat and softening blood vessels and granulation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Granules of the Chinese Medicine Composition for Lowering Blood Fat and Softening Blood Vessels of the Present Invention

[0033] The preparation of Qing Gao, a traditional Chinese medicine composition for lowering blood fat and softening blood vessels:

[0034] 25 parts of cassia seed, 75 parts of lotus leaf, 25 parts of Radix Polygoni Multiflori, 500 parts of hawthorn (pitted);

[0035] Concentrating the water extracts of Semen Cassiae and Hawthorn respectively to clear pastes with relative densities of 1.05-1.15, 1.15-1.25 and 1.25-1.30 (50°C) by using the prior art;

[0036] Concentrating the alcohol extracts of lotus leaf and Radix Polygoni Multiflori by using the prior art to clear pastes with relative densities of 1.05-1.15, 1.15-1.25 and 1.25-1.30 (50°C);

[0037] Three relative densities clear ointment samples prepared by concentrating the above-mentioned alcohol extract and water extract were mixed in pairs with similar densities, sti...

Embodiment 2

[0053]Example 2 Preparation of Granules of the Chinese Medicine Composition for Lowering Blood Fat and Softening Blood Vessels of the Present Invention

[0054] The preparation of the blood fat-lowering and blood-vessel softening traditional Chinese medicine composition clear ointment and powdered sugar is the same as that in Example 1.

[0055] Preparation of spray granulation: take 100kg of powdered sugar and put it in the spray granulator, set the inlet air temperature to 110°C, and boil for 15 minutes; At ≥50°C), start the peristaltic pump and adjust the atomization pressure to 0.3Mpa. Spray 65.0kg of ointment (batch number 20180502) to start granulation. After all the ointment is sprayed in, turn off the peristaltic pump and start the drying process, so that the formed granules continue to be dried by sending hot air in the bed. The drying time is 10 minutes, and stop drying when there is no sense of moisture.

[0056] Preparation of medicinal powder: take the sprayed g...

Embodiment 3

[0067] Example 3 Preparation of Granules of the Chinese Medicine Composition for Lowering Blood Fat and Softening Blood Vessels of the Present Invention

[0068] The preparation of the blood fat-lowering and blood-vessel softening traditional Chinese medicine composition clear ointment and powdered sugar is the same as that in Example 1.

[0069] Preparation of spray granulation: take 100kg of powdered sugar and put it in the spray granulator, set the inlet air temperature at 120°C, and boil for 15 minutes; At ≥50°C), start the peristaltic pump and adjust the atomization pressure to 0.4Mpa. Spray 55.0kg of ointment (batch number 20180503) to start granulation. After all the ointment is sprayed in, turn off the peristaltic pump and start the drying process so that the formed granules continue to be dried by hot air in the bed. The drying time is 12 minutes, stop drying when there is no sense of moisture.

[0070] Preparation of medicinal powder: take the spray granulated part...

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Abstract

The invention discloses granules of a traditional Chinese medicine composition for reducing blood fat and softening blood vessels and a granulation method thereof, belongs to the technical field of traditional Chinese medicine and natural medicine processing, and solves the problems in the prior art of preparation molding difficulty, long production cycle, high loss of active ingredients and poordissolubility. The granulation method comprises the step a of concentrating an aqueous extract of cassia seeds and hawthorn fruit to clearing paste; the step b of concentrating an alcohol extract of lotus leaves and polygonum multiflorum to the clearing paste; the step c of mixing the clearing paste in the step a and the step b with powdered sugar, combining a spraying granulation method and a swing granulation method, and drying to make the granules of the traditional Chinese medicine composition for reducing blood fat and softening blood vessels. Compared with the original granulation method, the granulation method has strong operability and short production cycle, and is suitable for industrialized large-scale production. The prepared granules have better solvability, and the solution clarity is improved after dissolution. The granules are small in loss of the effective ingredients, and the yield is high.

Description

technical field [0001] The invention relates to the technical field of processing traditional Chinese medicines and natural medicines, in particular to a granule of a Chinese medicine composition for lowering blood fat and softening blood vessels and a granulation method thereof. Background technique [0002] Jiangzhining granules are composed of four traditional Chinese medicines: cassia seed, lotus leaf, Polygonum multiflorum and hawthorn, which have the functions of lowering blood fat and softening blood vessels. Clinically used to enhance coronary blood circulation, anti-arrhythmia and hyperlipidemia. [0003] The original preparation process of Jiangzhining Granules adopts shaking granulation. Due to the large amount of ointment in the prescription, the granulation cannot be completed at one time. It needs to be added in batches, and it needs to go through 4-5 times of granulation, drying, crushing, and then adding ointment granulation. The process, the whole preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/16A61P3/06A61P9/06A61P9/10
CPCA61K9/1623A61K36/482A61K36/62A61K36/704A61K36/734A61K2236/331A61K2236/333A61P3/06A61P9/06A61P9/10A61K2300/00
Inventor 田涵雯隋义东陈革
Owner CHANGCHUN RENMIN PHARMA GROUP
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