Radix sophorae flavescentis lipidosome composite with inflammation reduction and odor removal functions and preparation method and application of composite

Abstract

The invention discloses a radix sophorae flavescentis lipidosome composite with inflammation reduction and odor removal functions and a preparation method and application of the composite. The radix sophorae flavescentis lipidosome composite comprises a radix sophorae flavescentis lipidosome and a skin relieving element lipidosome, the radix sophorae flavescentis lipidosome comprises a folium artemisiae argyi extract, a radix sophorae flavescentis extract, a green tea extract, a langehead atractylodes rhizome extract, an astragalus root extract and a blumea balsamifera extract, and the skin relieving element lipidosome comprises a ginger extract. The main active component of the radix sophorae flavescentis transdermal absorption lipidosome has the treatment functions of clearing heat, removing toxicity, removing dampness, relieving swelling and pain, removing odor and relieving tickle, quickly permeates into the skin through the transdermal effect and is directly applied to the coriumlayer, the skin relieving element lipidosome helps to promote timely discharging of metabolite, deposition and skin injuries are avoided, deep nursing and timely discharging of metabolite are achieved, the original one-way application mechanism is changed, the nursing dual-way transdermal absorption is achieved, and the composite can be applied to preparation of medicine for treating symptoms suchas gynecological inflammation pruritus.

Description

technical field [0001] The present invention relates to the technical field of anti-inflammatory and deodorant pharmaceutical preparations, and more particularly relates to a Sophora flavescens liposome composition with anti-inflammatory and deodorant effects and its preparation method and application. Background technique [0002] Vaginitis refers to the inflammation of vaginal mucosa and submucosal connective tissue, which is a common disease in gynecological clinics. According to statistics, about 42.1% of married women of childbearing age in my country have reproductive tract infection. Normal vaginal discharge is clear, transparent and odorless, and will not cause irritation and itching in the vulva. However, the discharge of vaginal inflammation is yellow and has a sour smell. The vaginal discharge will increase and cause vaginal discharge. Itching of the vulva. The clinical manifestations of general vaginitis include increased leucorrhea, yellow, yellow-green purule...

AI Technical Summary

Problems solved by technology

Western medicine is effective in treating vaginitis, although it is effective quickly, it is prone to drug resistance, and may relapse, and the treatment effect is not very good; while traditional Chinese medicine can be treated based on syndrome differentiation, although it is slow in effect, the curative effect is stable, and there are few adverse reactions. better

[0003] Chinese herbal ingredients such as Artemisia argyi have the effect of warming the meridian and relieving pain, but the current inflammation treatment drugs containing Chinese herbal ingredients such as Artemisia argyi are mostly prepared in the form of suppositories, and are rarely combined with transdermal lipid absorption preparations in the form of liposomes. The absorption effect is limited. Related The efficacy of the active ingredients of traditional Chinese medicine is also greatly reduced

Liposomes are composed of lipid bilayers, and closed vesicles with a water phase inside are called liposomes. The structure of liposomes is similar to biological membranes, so they are also called artificial biological membranes. Various substances can be wrapped in it. In recent years, with the continuous development of biotechnology, the preparation process of liposomes has been gradually improved, and it has been applied to a certain extent in daily chemical skin care, but it has not been reported in pharmaceutical preparations.

Prior art CN108542820A discloses a skin absorption accelerator, skin care matrix and its preparation method and application, but the liposome matrix in the prior art only has one-way transdermal absorption, and the metabolism produced after the active ingredient enters the skin Drugs also need to be slowly excreted from the body through natural mechanisms, which can easily cause deposition under the skin epidermis, affect the use effect, and even damage the skin

Therefore, only the above-mentioned Chinese medicine composition is prepared into a general liposome absorption preparation, although it is helpful for its absorption and utilization, there are also the above-mentioned side effects of metabolites.

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