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Steviol glycoside compositions for oral ingestion or use

A technology of steviol glycoside and composition, which is applied in the field of steviol glycoside composition and can solve the problems of unsatisfactory solubility of rebaudioside, high processing temperature and the like

Pending Publication Date: 2019-04-16
CARGILL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Certain approaches to improve rebaudioside solubility are less than ideal as they are labor intensive, require high processing temperatures and use excipient compounds

Method used

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  • Steviol glycoside compositions for oral ingestion or use
  • Steviol glycoside compositions for oral ingestion or use
  • Steviol glycoside compositions for oral ingestion or use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] Fermentation for the production of steviol glycosides including compounds SG101-104

[0198] Steviol glycoside compounds (including compounds SG101-104, rebaudioside D and rebaudioside M) were produced by genetically engineering Saccharomyces cerevisiae. Saccharomyces cerevisiae strains EFSC 3261 and EFSC 3841 are described in International Application No. WO2014 / 122227.

[0199] Batch-fed fermentations were performed aerobically in 2 L (working volume) fermenters, which consisted of A growth period of approximately 16 hours followed by a defined feed medium containing glucose for approximately 100 hours. Glucose is used as carbon and energy source and combined with trace metals, vitamins and salts. The pH was maintained around pH 5-6 with a temperature set point of 30 °C. Feed rates were controlled to prevent oxygen depletion and minimize ethanol formation (glucose-limited conditions). The fermentation basal medium is based on Verduyn C, Postma E, Scheffers WA, Van...

Embodiment 2

[0201] Purification and NMR spectrum of compound SG101-104

[0202] Compound SG101-104 (in figure 2 and 3 designated as OPS1-1, OPS1-2, OPS1-4 and OPS1-5 in the purification chromatograms shown in ) were purified by preparative liquid chromatography as follows. Dried fermentation broth enriched in these compounds was used as starting material for purification. The material was dissolved in 50:50 ethanol:water by sonication at 50°C. 5 mL of the solution was filtered through a 0.2 μm nylon syringe tip filter into a 5 mL autosampler vial for injection onto an Agilent 1260 preparative LC.

[0203] Compound SG101 (OPS1-1) and Compound SG102 (OPS1-2) fractions were purified as follows: 2.5 mL of sample was injected onto a Phenomenex Kinetex XB-C18 5 μm, 21.2×250 mm column. A mixture of methanol and water (40:60 v / v) was used as solvent. The flow rate was set at 20 mL / min and the maximum pressure was 400 bar. figure 2 SG101 and SG102 purification chromatograms are shown. Via...

Embodiment 3

[0209] Steviol glycoside composition purified from fermentation broth

[0210] The steviol glycoside composition prepared from Example 1 was analyzed to determine the type and amount of steviol glycoside compounds, including compounds SG101-104.

[0211] Table 1. Overview of 140501-B1

[0212]

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PUM

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Abstract

Compositions and uses for steviol glycoside compounds having four glucopyranose residues attached via the number 13 carbon (C13) of the steviol moiety and a second group of two or three glucopyranoseresidues attached via the number 19 carbon (C19) of the steviol moiety are described, and exemplified by compounds SG101-104. A steviol glycoside composition including one or more of compounds SG101-104 in combination with other steviol glycosides including other rebaudiosides can be used as a sweetener composition to sweeten other compositions (sweetenable compositions) such as foods, beverages,medicines, oral hygiene compositions, pharmaceuticals, nutraceuticals, and the like.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 351,640, entitled STEVIOL GLYCOSIDE COMPOUNDS FOR ORALINGESTION OR USE, filed June 17, 2016, which states The patent application is hereby incorporated by reference in its entirety. [0003] This application is related to International Application No. PCT / US2015 / 066419, filed December 17, 2015, which is related to U.S. Provisional Application No. 62 / 093,213, filed December 17, 2014, both of which are incorporated herein by reference in their entirety . technical field [0004] The present disclosure relates to steviol glycoside compositions having a plurality of steviol glycosides and methods of use thereof. The present disclosure also relates to sweetener compositions and syrups to prepare sweetened compositions, including foods, beverages, dental products, pharmaceuticals, nutraceuticals, and the like. Background technique [0005] S...

Claims

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Application Information

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IPC IPC(8): C07H15/256
CPCC07H15/256A23L27/00A23L27/36A23L2/60
Inventor 汀·柳·卡尔森丹·S·加斯帕德迈克尔·艾伦·莫滕森
Owner CARGILL INC
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