Zinc-cooper coating for bone implantation and preparation method thereof

A technology of copper coating and bone implantation, which is applied in medical materials, filling materials for joint replacement and human tissue defects, antibacterial implant materials, and dental implants. It can solve the problems of unsatisfactory adhesion and growth of bone cells. , to achieve the effect of improving immunity, wide application range and good biocompatibility

Inactive Publication Date: 2019-04-19
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Metal materials have always been considered to be biologically stable. Although people have carried o

Method used

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  • Zinc-cooper coating for bone implantation and preparation method thereof
  • Zinc-cooper coating for bone implantation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Put the porous titanium alloy (Ti-6Al-4V) sample into the furnace body 1 of the deposition chamber; put the copper chloride powder into the furnace body 2 of the evaporation chamber, and put pure zinc into the high temperature zone of the furnace body 1 of the deposition chamber, and the atomic ratio is Zinc: copper chloride = 25:1, then connect the air circuit, check the sealing condition, and draw a limit vacuum (10 -4 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 300°C, the zinc evaporation temperature to 700°C, the copper chloride source evaporation temperature to 200°C, the working vacuum degree to 5Pa, the hydrogen flow rate to 50SCCM, the deposition time to 3h, the thickness of the deposited metal zinc-copper layer to be 200μm, and the mass of copper The percentage is 2%. In order to determine the effect of the coating on promoting osteogenesis, an alkaline phosph...

Embodiment 2

[0026] Put the porous titanium alloy (Ti-6Al-4V) sample into the furnace body 1 of the deposition chamber; put the copper chloride powder into the furnace body 2 of the evaporation chamber, and put pure zinc into the high temperature zone of the furnace body 1 of the deposition chamber, and the atomic ratio is Zinc: copper chloride = 20:1, then connect the air circuit, check the sealing condition, and draw a limit vacuum (10 -4 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 200°C, the zinc evaporation temperature to 600°C, the copper chloride source evaporation temperature to 300°C, the working vacuum to 5Pa, the hydrogen flow to 100SCCM, the deposition time to 2h, the thickness of the deposited metal zinc-copper layer to be 100μm, and the mass of copper The percentage is 5%.

Embodiment 3

[0028] Put the porous titanium alloy (Ti-6Al-4V) sample into the furnace body 1 of the deposition chamber; put the copper chloride powder into the furnace body 2 of the evaporation chamber, and put pure zinc into the high temperature zone of the furnace body 1 of the deposition chamber, and the atomic ratio is Zinc: copper chloride = 15:1, then connect the air circuit, check the sealing condition, and draw a limit vacuum (10 -4 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 150°C, the zinc evaporation temperature to 500°C, the copper chloride source evaporation temperature to 300°C, the working vacuum to 50Pa, the hydrogen flow to 100SCCM, the deposition time to 1.5h, and the thickness of the deposited metal zinc-copper layer to be 150μm, copper The mass percentage is 7%.

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PUM

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Abstract

In order to solve the problem of bone bonding and infection of implant materials, the invention provides a zinc-cooper coating for bone implantation and a preparation method thereof. A chemical vapordeposition technology and an evaporation technology are adopted, the zinc-cooper coating is prepared on an entity made of titanium and titanium alloy, cobalt-based alloy, stainless steel, a polymer material or mesh-shaped glass carbon and a porous structure base body, wherein the thickness of the coating is 0.1-200 microns, and the coating comprises, by mass, greater than 0% and less than or equalto 10% of Cu. According to the zinc-cooper coating for bone implantation and the preparation method thereof, the problems of bone compatibility and infection of existing implant materials can be solved; and the permanent implantation material obtained by using the preparation method is suitable for mechanical property requirements of various implantation parts, is excellent in biocompatibility and has a sterilization function at the same time.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to dental implants, joint replacements and filling materials for human tissue defects and the antibacterial technical field of implant materials; in particular, it is a zinc-copper coating material on the surface of implants and a preparation method thereof . Background technique [0002] Implants such as artificial joints only have a lifespan of 10-15 years due to adverse cell reactions caused by implant loosening and abrasion, which cannot meet the long-term use requirements. Meanwhile, infection remains one of the disastrous postoperative complications of orthopedic implants. Metallic foreign bodies implanted in the body are risk factors for such infections, and a series of in vivo reactions, including the weakening of macrophage function and the passivation of the local immune system, create favorable conditions for the proliferation of pathogens. In addition, the proteins ads...

Claims

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Application Information

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IPC IPC(8): C23C14/24C23C14/14C23C16/14A61L27/30A61L27/54A61L27/58
CPCA61L27/306A61L27/54A61L27/58A61L2300/102A61L2300/404A61L2300/412A61L2300/45A61L2300/606A61L2400/18A61L2420/02A61L2420/06A61L2430/02C23C14/14C23C14/24C23C16/14
Inventor 于晓明谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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