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Quartz crystal microbalance (QCM) and localized surface plasmon resonance (LSPR) biosensor with transparent electrode

A biosensor and transparent electrode technology, which is applied in the field of semiconductor physical devices, can solve the problems of inability to distinguish the quality of biomolecules and the quality of coupling solvents, achieve good technical prospects, and enhance the effect of extinction spectrum signal intensity

Inactive Publication Date: 2019-04-23
JIANGSU UNIV OF SCI & TECH
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Problems solved by technology

However, QCM (Quartz Crystal Microbalance, quartz crystal microbalance) is also a quartz wafer. The measured mass of the substance is the total adsorption mass, and it is impossible to distinguish the mass of biomolecules from the mass of the coupling solvent.

Method used

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  • Quartz crystal microbalance (QCM) and localized surface plasmon resonance (LSPR) biosensor with transparent electrode
  • Quartz crystal microbalance (QCM) and localized surface plasmon resonance (LSPR) biosensor with transparent electrode
  • Quartz crystal microbalance (QCM) and localized surface plasmon resonance (LSPR) biosensor with transparent electrode

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Embodiment Construction

[0019] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0020] Such as figure 1 , 2 , 3, a QCM and LSPR biosensor with transparent electrodes consists of a quartz wafer 1, an ITO electrode 2 prepared on the top of the quartz wafer 1 and a gold electrode 3 at the bottom, and silver nanoparticles 5 prepared on the ITO electrode 2. The biosensor combines QCM technology and nanomaterial-based LSPR technology to form a dual-technology fusion sensor, enabling the two technologies to operate simultaneously to obtain complex biofilm parameters. The pair of working electrodes of the quartz wafer 1 in the QCM part are the ITO electrode 2 on the top and the gold electrode 3 on the bottom respectively, and the quartz wafer 1 is oscillated based on the piezoelectric effect. The LSPR phenomenon is achieved by chemically disposing silver nanoparticles 5 on the ITO electrode 2 . Modification of biological probes...

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Abstract

The invention discloses a quartz crystal microbalance (QCM) and localized surface plasmon resonance (LSPR) biosensor with a transparent electrode. The quartz crystal microbalance (QCM) and localized surface plasmon resonance (LSPR) biosensor with the transparent electrode is composed of a quartz wafer, an indium tin oxide (ITO) electrode prepared at the top of the quartz wafer, a gold electrode prepared at the bottom of the quartz wafer, and silver nanoparticles prepared on the ITO electrode. According to the biosensor, a QCM technology and an LSPR technology based on the nanomaterial silver nanoparticles are combined to form a dual technology fusion sensor to enable the two technologies to operate simultaneously to obtain complex biofilm parameters, wherein a pair of working electrodes ofthe quartz wafer in a QCM part are the ITO electrode at the top and the gold electrode at the bottom correspondingly, and based on the piezoelectric effect, the working electrodes make the quartz wafer oscillate. The silver nanoparticles are arranged on the ITO electrode through a chemical method to achieve the LSPR phenomenon. The silver nanoparticles are modified with biological probes for detecting protein biomolecules.

Description

technical field [0001] The invention relates to a QCM and LSPR biosensor with a transparent electrode, in particular to a biosensor with a combined structure of a transparent electrode-gold electrode, so as to realize the simultaneous measurement of biomolecules by QCM and LSPR technology, and belongs to the field of semiconductor physical devices . Background technique [0002] A quartz wafer is a noninvasive electromechanical sensor sensitive to small mass changes on its surface. The quartz crystal oscillator is excited by an external voltage to form a mechanical shear oscillation in the quartz crystal, and its frequency can be the fundamental frequency or harmonic frequency. When the mass of the adsorbed substance is much smaller than that of the quartz wafer, and the adsorbed substance is evenly and rigidly distributed on the surface of the quartz wafer, the variation Δf of the resonant frequency of the quartz crystal oscillator is proportional to the variation Δm of th...

Claims

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Application Information

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IPC IPC(8): G01N29/02G01N29/036G01N21/552C12Q1/68
CPCC12Q1/68G01N21/554G01N29/022G01N29/036G01N2291/014
Inventor 朱琎马澄
Owner JIANGSU UNIV OF SCI & TECH
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