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Preparation method and application of multifunctional pcs hybrid nanofiber biomedical elastomer

A nanofiber, biomedical technology, applied in the field of preparation of multifunctional PCS hybrid nanofiber biomedical elastomer, can solve the problems of less function, no anti-microbial infection ability, no photothermal ability, photothermal therapy, etc. Achieve strong photothermal properties and good monomer biocompatibility

Active Publication Date: 2020-08-28
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, at present, most bioelastomer applications still have the shortcomings of few functions, such as lack of imaging ability to achieve real-time tracking, lack of anti-microbial infection ability to cause graft infection, lack of photothermal ability to achieve photothermal therapy, etc.

Method used

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  • Preparation method and application of multifunctional pcs hybrid nanofiber biomedical elastomer
  • Preparation method and application of multifunctional pcs hybrid nanofiber biomedical elastomer
  • Preparation method and application of multifunctional pcs hybrid nanofiber biomedical elastomer

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preparation example Construction

[0043] 1) Preparation of PCS prepolymer: Add citric acid and 1,8-octanediol in a molar ratio of 1:1 into a 50mL round bottom flask, conduct thermal polymerization in an oil bath at 160°C under the protection of nitrogen, and wait until it is completely melted Finally, after adding (3-aminopropyl)triethoxysilane, cool down to 140°C and react for 2 hours; the product is purified in deionized water, freeze-dried and retained;

[0044] 2) Preparation of CSNW nanofibers: First, 1.0 mmol of cuprous(I) chloride (CuCl) and 10.0 ml of oleylamine (OM) were added into a three-necked flask (50 mL) at room temperature, and heated in vacuum to 130°C to remove oxygen and water. At the same time, 2.5 mmol of sodium diethyldithiocarbamate (NaDDTC) was dispersed in 6.0 ml of OM by ultrasonic waves, injected into the CuCl / OM solution at 260 °C, and then the mixture was kept at 260 °C for 15 min, the color It is gray-black. The precipitate (CSNW) was collected by centrifugation at 8500 rpm for ...

Embodiment 1

[0058] 1) Preparation of PCS prepolymer: citric acid with a total mass of 6g, 1,8-octanediol and (3-aminopropyl) triethoxysilane according to 1:1:0.4, firstly mix citric acid and 1, Add 8-octanediol to a 50mL round-bottomed flask, stir and melt in an oil bath at 160°C under nitrogen atmosphere; after it is completely melted, immediately lower the temperature to 140°C, add (3-aminopropyl)triethoxy Silane, reacted under nitrogen atmosphere for 2h. The reaction product was dissolved in DMSO, purified by dialysis in deionized water for 2 days, and freeze-dried for later use;

[0059] 2) Preparation of CSNW nanofibers: First, 1.0 mmol of cuprous(I) chloride (CuCl) and 10.0 ml of oleylamine (OM) were added into a three-necked flask (50 mL) at room temperature, and heated in vacuum to 130°C to remove oxygen and water. At the same time, 2.5 mmol of sodium diethyldithiocarbamate (NaDDTC) was dispersed in 6.0 ml of OM by ultrasonic waves, and it was injected into the CuCl / OM solution ...

Embodiment 2

[0062] 1) Preparation of PCS prepolymer: citric acid with a total mass of 6g, 1,8-octanediol and (3-aminopropyl) triethoxysilane according to 1:1:0.4, firstly mix citric acid and 1, Add 8-octanediol to a 50mL round-bottomed flask, stir it in a nitrogen atmosphere and melt it in an oil bath at 160°C; Silane, reacted under nitrogen atmosphere for 2h. The reaction product was dissolved in DMSO, purified by dialysis in deionized water for 2 days, and freeze-dried for later use;

[0063] 2) Preparation of CSNW nanofibers: First, 1.0 mmol of cuprous(I) chloride (CuCl) and 10.0 ml of oleylamine (OM) were added to a three-necked flask (50 mL) at room temperature, and heated in vacuum to 130°C to remove oxygen and water. At the same time, 2.5 mmol of sodium diethyldithiocarbamate (NaDDTC) was dispersed in 6.0 ml of OM by ultrasonic waves, and it was injected into the CuCl / OM solution at 260 °C, and then the mixture was kept at 260 °C for 15 min. It is gray-black. The precipitate (C...

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Abstract

The invention discloses a preparation method and application of a multifunctional PCS hybridized nanometer fiber biomedical elastomer. Macromolecule PCS with good biological compatibility and good photoluminescence is adopted and compounded with multifunctional nanometer fibers to prepare the PCS hybridized nanometer fiber biomedical elastomer. According to a thermal polymerization method for usage, the synthesized elastomer is modified and wrapped by macromolecules to obviously reduce ion release in the nanometer fibers, accordingly, biological toxicity is reduced, meanwhile, an original photothermal effect is kept, and an original antibacterial effect is kept. In this way, in the preparation method, the nanometer fibers and PCS conduct a polymerization reaction through a mild chemical method to form the multifunctional PCS hybridized nanometer fiber biomedical elastomer, and the multifunctional PCS hybridized nanometer fiber biomedical elastomer can be used for synthesizing an antibacterial and degradable multifunctional PCS-CSNW nanometer composite elastomer capable of conducting near infrared photo-thermal treatment, and can be used for synthesizing a multifunctional PCS-LHNW nanometer fiber composite material with fluorescence enhancement and magnetic imaging.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a preparation method and application of a multifunctional PCS hybrid nanofiber biomedical elastomer. Background technique [0002] Tissues of the human body, including hard tissues (bone) and soft tissues (skin, blood vessels, muscles) have superior viscoelastic mechanical properties. The development of biodegradable elastomer materials with elastic behavior has become an important direction of regenerative medicine and organ replacement. Bioelastomers have made important progress in the fields of functional implants, medical catheters, bandages, prosthetics, artificial organs, and plastic surgery. Bioelastomers currently reported in clinical and research studies, such as polyester and silicone rubber, have excellent biocompatibility, bionic mechanical properties, and controllable biodegradability. In recent years, polycitrate, a biodegradable...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/14C08G18/32C08G77/445
Inventor 雷波李艳男李娜张新瑜
Owner XI AN JIAOTONG UNIV
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