A kind of method and product suitable for detecting the content of oquindox in veterinary drug preparations

Abstract

The invention discloses a method and a product for detecting the content of oquindox in a veterinary drug preparation. The product used in the detection is the octoplast hapten compound shown in formula I. The invention relies on the basic principles of immunology and immunochemistry and the technical means of residual analysis to design and synthesize small molecule target analyte hapten, and couple with carrier protein to prepare effective artificial antigen, and immunize animals to prepare specificity for small molecule analyte. Antibody. Using the specific immunological reaction of antigen and antibody, it can quantitatively detect the target analyte of trace small molecule in the sample, which has the characteristics of specificity, sensitivity, accuracy, rapidity, convenience and low cost.

Description

technical field

[0001] The invention belongs to the detection field, and relates to a method and a product for detecting the content of olaquindox in veterinary drug preparations. Background technique

[0002] Olaquindox (OLA) is a broad-spectrum quinoxaline antibacterial drug, which can promote protein assimilation and can significantly increase feed remuneration. Therefore, it was widely used in the breeding industry as a feed additive for livestock and poultry in the early days. However, olaquindox has obvious cumulative toxicity and certain genotoxicity in the body, has obvious teratogenic effects on most animals, and has potential triplicity to humans. "The Veterinary Pharmacopoeia of the People's Republic of China" (2005 edition) stipulates that olaquindox is prohibited from being used in poultry, aquatic animals and pigs above 35kg. In 2017, the Office of Veterinary Pharmacopoeia of China prohibited the use of olaquindox as a drug feed additive in food animals. Howe...

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