Synthetic method of H&E-like image and optical system adopting same

A synthesis method and H&E technology, applied in the field of synthesis methods and optical systems adopting the method, can solve problems such as damage to samples to be tested, long-term waste of fluorescent dyes, and need for improvement in color contrast.

Pending Publication Date: 2019-05-14
ACUSOLUTIONS INC
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] However, since the patent framework uses multiple fluorescence images to generate H&E-like images, it still has the following disadvantages: (1) The color contrast of this type of H&E images still needs to be improved because the structu...

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  • Synthetic method of H&E-like image and optical system adopting same
  • Synthetic method of H&E-like image and optical system adopting same
  • Synthetic method of H&E-like image and optical system adopting same

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Embodiment Construction

[0033] Please refer to figure 1 , which shows a flowchart of a method for synthesizing H&E-like images in a preferred embodiment of the present invention.

[0034] Such as figure 1 Shown, the synthesis method of class H&E image of the present invention comprises the following steps:

[0035]Input a grayscale interference image or grayscale reflection image of a sample to be tested into a first storage block of an information processing device, and input a grayscale fluorescence image of the sample to be tested into a first storage block of the information processing device In the second storage block (step a); use the information processing device to convert the gray-scale interference image or gray-scale reflection image into a first RGB image through a first color conversion operation, and use the information processing device to convert the gray-scale image The step fluorescence image is converted into a second RGB image through a second color conversion operation (step b...

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Abstract

The invention discloses a synthetic method of an H&E-like image. The method comprises the following steps: inputting a gray scale interference image or a gray scale reflection image of a to-be-detected sample into a first storage block of an information processing device, and inputting a gray scale fluorescence image of the to-be-detected sample into a second storage block of the information processing device; converting the gray-scale interference image or the gray-scale reflection image into a first RGB image through a first color conversion operation by using the information processing device, and converting the gray-scale fluorescence image into a second RGB image through a second color conversion operation by using the information processing device; an image fusion operation and an intensity inversion operation are performed on the first RGB image and the second RGB image by using the information processing device to generate a class of H & E images. In addition, the invention also discloses an optical system adopting the method.

Description

technical field [0001] The invention relates to an image synthesis method of an optical system, in particular to an H&E (Hematoxylin and Eosin, hematoxylin and eosin) image synthesis method and an optical system using the method. Background technique [0002] When performing tumor resection, it is often necessary to wait for the pathologist to use a frozen section (frozen section) to test to determine whether the tumor is completely removed. However, in the process of frozen sectioning, if the sample to be tested is a sample with a lot of water, it will produce ice crystals (crystal ice) that destroy the tissue structure after freezing; and if the sample to be tested is a sample with a lot of fat (fat), At the temperature (~-20°C) where all tissues have been frozen and solidified, the adipose tissue will easily fall off from the slice because it has not been frozen and solidified, resulting in incomplete sliced ​​tissue. In addition, frozen cells are not easy to be stained ...

Claims

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Application Information

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IPC IPC(8): G06T5/50
Inventor 蔡建中许光裕
Owner ACUSOLUTIONS INC
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