Mouse fixing device for epilepsy research experiments

A fixed device and experimental technology, applied in veterinary instruments, medical science, and animal restraint instruments, etc., can solve the problems of poor safety performance, poor mouse immobilization effect, and small application range, and achieve the effect of preventing rats from escaping and immobilizing Good, wide range of effects

Inactive Publication Date: 2019-05-21
THE FIRST PEOPLES HOSPITAL OF NANTONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the process of epilepsy research, mice are generally used for experiments, and the mice need to be fixed during the experiment. However, the existing mouse fixing devices are not easy to use, and the effect of fixing the mice is relatively poor, which cannot prevent the mice from being crushed by the head. Death due to injury cannot guarantee the smooth progress of the experiment, and the rats are easy to escape, and the rats struggled a lot during the experiment, resulting in excessive physical exertion of the rats and inaccurate experimental results, which cannot guarantee the smooth progress of the epilepsy experiment. It does not have the function of collecting mouse urine and saliva. During the experiment, the mouse's saliva and urine are easy to pollute the laboratory. The safety performance is poor, and the limbs of the mouse cannot be fixed, which will cause the mouse to scratch the experimenter. The scope of application is small. Cannot be used to immobilize mice of different sizes, for this reason, an experimental mouse immobilization device for epilepsy research is proposed

Method used

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  • Mouse fixing device for epilepsy research experiments
  • Mouse fixing device for epilepsy research experiments
  • Mouse fixing device for epilepsy research experiments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A mouse immobilization device for epilepsy research experiments, such as figure 1 As shown, it includes a fixed platform 1, a head fixed unit 2, a spine fixed unit 3, a limb fixed unit 4 and a bottom support unit 5. The fixed platform 1 is detachably installed on the top of the bottom support unit 5, and the The head fixation unit 2 is installed on the upper side of the fixed platform 1, the spine fixation unit 3 is installed in the upper middle of the fixed platform 1, and the limb fixation unit 4 is installed on the bottom of the fixed platform 1 .

[0056] By adopting the above-mentioned technical scheme, the bottom supporting unit 5 is used to support the whole device, the head fixing unit 2 is used to fix the head of the mouse, the limb fixing unit 4 is used to fix the limbs of the mouse, and the spine fixing unit 3 is used to fix the mouse's limbs. The back of the spine, the above makes the effect of immobilizing the mice better, which can prevent the mice from e...

Embodiment 2

[0076] The difference from Example 1 is that the surface of the base 32 and the support platform 6 is also provided with a protective layer, and the protective layer is prepared by the following method:

[0077] Take the following raw materials and weigh them by weight: 25 parts of epoxy resin, 10 parts of titanium dioxide powder, 10 parts of natural rubber particles, 10 parts of phenolic resin, 8 parts of mica powder, 15 parts of polyurethane, 3 parts of paraffin wax, 2 parts of alcohol ester twelve , 2 parts of triethanolamine, 2 parts of emulsified silicone oil and 30 parts of water;

[0078] S1. Add the weighed paraffin wax, alcohol ester dodeca, triethanolamine, emulsified silicone oil and water into the mixer and stir for 20min at a stirring speed of 600r / min to prepare a mixed solution;

[0079] S2, adding epoxy resin, titanium dioxide powder, natural rubber particles, phenolic resin, mica powder and polyurethane into a pulverizer for pulverization, until the particle d...

Embodiment 3

[0085] The difference with embodiment 2 is the preparation of protective layer, and its specific preparation method is as follows:

[0086] Take the following raw materials and weigh them by weight: 30 parts of epoxy resin, 12 parts of titanium dioxide powder, 11 parts of natural rubber particles, 12 parts of phenolic resin, 9 parts of mica powder, 17 parts of polyurethane, 4 parts of paraffin wax, 3 parts of alcohol ester twelve , 3 parts of triethanolamine, 3 parts of emulsified silicone oil and 40 parts of water;

[0087] S1. Add the weighed paraffin, alcohol ester dodeca, triethanolamine, emulsified silicone oil and water into the mixer and stir for 25min at a stirring speed of 700r / min to prepare a mixed solution;

[0088] S2, adding epoxy resin, titanium dioxide powder, natural rubber particles, phenolic resin, mica powder and polyurethane into a pulverizer for pulverization, until the particle diameter of the material is not greater than 100nm, and a mixed powder materi...

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Abstract

The invention discloses a mouse fixing device for epilepsy research experiments, which comprises a fixing platform, a head fixing unit, a vertebrae fixing unit, a limb fixing unit and a bottom supporting unit, wherein the fixing platform is detachably arranged on the upper part of the bottom supporting unit. The device can be used conveniently; the device has better effect of fixing the mouse, canprevent the head of the mouse from being crushed, and can prevent the mouse from being killed due to the crushing of the head, thereby ensuring the smooth progress of the epilepsy research experiments, preventing the mouse from escaping, and preventing the mouse from greatly struggling during the experiments to cause the experimental result to be inaccurate; the device can effectively ensure thesmooth progress of the epilepsy research experiments, has the function of collecting mouse urine and oral water, and can prevent the oral water and the urine of the mouse from polluting the laboratoryin the experimental process; the device is safe and reliable, can prevent the mouse from scratching the experimental personnel, has wide application range and can be used for fixing the mice with different sizes.

Description

technical field [0001] The invention relates to the technical field of experimental equipment, in particular to a mouse fixation device for epilepsy research experiments. Background technique [0002] Epilepsy is the second most persistent disease of the nervous system, especially status epilepticus SE, which is a life-threatening emergency with high morbidity and mortality. Currently, the International League Against Epilepsy defines SE as follows: SE refers to a seizure that lasts for more than 30 minutes, or a seizure that lasts for more than 30 minutes, or a seizure that fails to recover consciousness during the intermittent period for more than 30 minutes. In SE, the seizure lasts for a long time without any cessation or recurrence. The state of consciousness does not return to baseline during the second seizure. The mechanism of SE can be considered to be abnormally long (after t1 time) seizures due to the failure of the mechanism to terminate epilepsy or the emergenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D3/00
Inventor 叶子
Owner THE FIRST PEOPLES HOSPITAL OF NANTONG
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