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Viscid germander herb anti-inflammatory paints and preparation method thereof

A film-coating agent and Huxiang technology, which can be used in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of poor water-solubility and fat-solubility, unable to exert long-lasting medicinal effects, inconvenient to carry and use, etc. Effects of natural smell, improved drug stability and bioavailability, convenient administration

Active Publication Date: 2019-05-21
苏州伍角星生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Lamiaceae plant gossamnia is a real medicinal material in Guangdong. It is commonly known as blood and sorrow. There are many problems such as fast loss of medicine solution, a lot of waste, and the inability to exert the medicine effect for a long time, and the patient's compliance is poor, and it is inconvenient to carry and use
In addition, the material basis of the anti-inflammatory effect of goshen, that is, the total triterpenes of goshen, has poor water solubility and fat solubility, which greatly limits its application in the pharmaceutical industry and daily chemical industry, resulting in low bioavailability
Therefore, it is of practical significance how to use the anti-inflammatory substances of gossamia to prepare anti-inflammatory products and solve the problems of inconvenient portability and low bioavailability.

Method used

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  • Viscid germander herb anti-inflammatory paints and preparation method thereof
  • Viscid germander herb anti-inflammatory paints and preparation method thereof
  • Viscid germander herb anti-inflammatory paints and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] (1) Mix the water phase (the concentration of the triterpenoids in the water phase is 8.15mg / mL) containing the extract of the gossammonia triterpenoids with the oil phase at a volume ratio of 1:0.8, and heat the mixture at 50°C and 1 rpm Stir evenly per second, until the liquid is clear, and make the microemulsion containing the triterpenoid extract of the mountain gooseberry, wherein the oil phase is PEG-40 (hydrogenated castor oil) with a volume ratio of 8:2:1.5:0.5, and the mass concentration is 1% konjac glucomannan glue (1g konjac glucomannan is dissolved in deionized water to obtain 100mL of viscous liquid, which is the konjac glucomannan glue with a mass concentration of 1%), isopropyl myristate A mixture of esters and camellia oil;

[0067] (2) Add povidone K30 and polyvinyl alcohol-124 with a mass ratio of 2:1, and glycerol in an amount of 3mL / 100mL of the blank coating agent to 85% ethanol by volume fraction of the blank coating agent, Swell naturally at roo...

Embodiment 2

[0071] Change the mass ratio of povidone K30 and polyvinyl alcohol-124 in the embodiment 1 step (2) to 2.1:1, change the volume fraction of ethanol into the blank coating agent to 90%, and other conditions are the same as in embodiment 1. Prepare the anti-inflammatory varnish (every milliliter is equivalent to crude drug 15g)

[0072] The appearance of the prepared mountain gooseberry anti-inflammatory coating agent is tan, clear, uniform, no oil drop, no delamination phenomenon, and sticky texture. It is used to test the skin of guinea pigs and shows that it has good adhesion and is not easy to fall off. When lifted, there is no residue on the surface.

Embodiment 3

[0081] In Vitro Skin Transdermal Experiment of Shanhuxiang Anti-inflammatory Coating

[0082] (1) Preparation of isolated mouse skin: after the rat was anesthetized by intraperitoneal injection of 5% (w / v) chloral hydrate (injection volume: 1 mL per 100 g of rat injection), the back of the rat was fixed on the mouse board, and the Carefully remove the abdominal hair with a shaver, kill the mouse, cut off the skin, peel off the subcutaneous fat layer, wash and soak in normal saline, store at -15~-20°C until use, thaw naturally before use, and check its integrity;

[0083] (2) Get three kinds of anti-inflammatory coatings containing the different concentrations of the gossammonia triterpenoid extract: high concentration I group (per milliliter is equivalent to 15g crude drug, made by Example 2), medium concentration group II (every milliliter Milliliter is equivalent to 10g crude drug), low-concentration III group (per milliliter is equivalent to 5g crude drug) (the preparation ...

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Abstract

The invention discloses viscid germander herb anti-inflammatory paints and a preparation method thereof. The viscid germander herb anti-inflammatory paints are prepared from, by mass, 1.8-2.2% of a micro emulsion containing a viscid germander herb triterpenes extract and 1% of blank paints, wherein the micro emulsion comprises an aqueous phase and an oil phase of which the volume ratio is 1:(0.75-0.95), and the blank paints are composed of povidone, poval, a plasticizer and ethyl alcohol. The preparation method comprises the steps that the aqueous phase and the oil phase which contain viscid germander herb triterpenes are mixed and stirred to prepare the micro emulsion, then the micro emulsion and the blank paints are stirred and mixed uniformly, and the viscid germander herb anti-inflammatory paints are prepared. The viscid germander herb anti-inflammatory paints have the advantages that the preparation process is simple, economical and practical, and the viscid germander herb anti-inflammatory paints contain viscid germander herb and tea oil camellia oil, and have antibacterial, anti-inflammatory, astringent and heat-clearing effects.

Description

technical field [0001] The invention belongs to the technical field of external preparations, and in particular relates to an anti-inflammatory film coating agent of mountain gooseberry and a preparation method thereof. Background technique [0002] Film coating agent refers to an external preparation made by dissolving film-forming materials in organic solvents and mixing them with drugs. When used, it is applied to the affected area. After the solvent evaporates, a thin film is formed to protect the wound surface, and at the same time, the contained medicine is gradually released. The preparation process of the film-coating agent is simple, and it is convenient to use. After administration, the drug can be released at a certain rate, avoiding the first-pass effect, and reducing the toxic and side effects of the drug and other adverse reactions. [0003] Lamiaceae plant gossamnia is a real medicinal material in Guangdong. It is commonly known as blood and sorrow. There ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/107A61K47/10A61K47/36A61K47/14A61K47/46A61K47/32A61K36/53A61P29/00
Inventor 舒洁倩梁盈军袁娴李子行
Owner 苏州伍角星生物医药技术有限公司
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