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Application of red mushroom extracts in preparing preparation for treating and/ or preventing liver injury related diseases caused by high fat diet

A technology of high-fat diet and extract, which is applied in the application field of red mushroom extract in the preparation of preparations for the treatment and/or prevention of diseases related to liver damage caused by high-fat diet, and can solve the problems of decreased bacterial diversity, increased fat mass, Intestinal flora structural imbalance and other problems, to achieve the effect of alleviating the deterioration of inflammation, high utilization rate of raw materials, and improving physiological and pathological indicators

Inactive Publication Date: 2019-05-21
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have confirmed that: (1) Intestinal flora is related to obesity. Obese people have intestinal flora structure disorder and decreased bacterial diversity; obese mice have fewer Bacteroidetes and more Firmicutes; Transplantation of gut microbes into germ-free mice leads to increased fat mass in the latter

Method used

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  • Application of red mushroom extracts in preparing preparation for treating and/ or preventing liver injury related diseases caused by high fat diet
  • Application of red mushroom extracts in preparing preparation for treating and/ or preventing liver injury related diseases caused by high fat diet
  • Application of red mushroom extracts in preparing preparation for treating and/ or preventing liver injury related diseases caused by high fat diet

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preparation example Construction

[0034] In the fifth aspect of the present invention, a preparation method of russula extract is provided, comprising: after crushing the fruiting body of russula, sequentially extracting with alcohol, water, and sodium hydroxide (NaOH aqueous solution) to obtain The solution is extracted, concentrated and freeze-dried respectively to obtain the alcohol extract of the russula, the water extract of the russula and the alkali extract of the russula.

[0035] Preferably, a preparation method of Russula russula extract comprises: after crushing the fruiting body of Russula russula, extracting with 95% ethanol, water, and 1%-2% NaOH alkaline water successively to obtain extraction solutions respectively, and then separately After concentrating and freeze-drying, the alcohol extract of russula, water extract of russula and alkali extract of russula are obtained.

[0036] Preferably, a method for preparing a russula extract, comprising: crushing the fruit body of russula, extracting w...

Embodiment 1

[0050] Embodiment 1: the preparation of russula extract, the steps are as follows:

[0051] (1) Pulverize the fruiting bodies of Russula russula, use ethanol with a solid-to-liquid ratio of 1:8-1:15, extract by reflux for 2-4 hours, filter with suction, obtain the filtrate, concentrate under reduced pressure to obtain a thick paste of appropriate concentration, thick paste Freeze overnight at -80°C and dry in a freeze dryer to obtain the alcohol extract of Russatus.

[0052] (2) Take the above-mentioned filter residue after alcohol extraction, use water with a material-to-liquid ratio of 1:8-1:15, reflux extraction for 1-3 hours, and suction filter to obtain the filtrate, concentrate under reduced pressure to obtain a thick paste of appropriate concentration, The thick paste was frozen overnight at -80°C, and dried in a freeze dryer to obtain the water extract of Russula edodes.

[0053] (3) Take the above-mentioned filter residue extracted by alcohol and water, use 2% NaOH a...

Embodiment 2

[0057] Example 2: Improvement effect of russula extract on liver injury in obese mice induced by high-fat diet

[0058] 1. Reagents:

[0059] Total cholesterol (T-CHO) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0060] Triglyceride (TG) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0061] Low-density lipoprotein cholesterol (LDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0062] High-density lipoprotein cholesterol (HDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0063] Alanine aminotransferase (ALT) test kits, total protein (TP) test kits, albumin (ALB) test kits and globulin (GLB) test kits were purchased from Nanjing Jiancheng Bioengineering Institute.

[0064] Thirty female C57 mice, SPF grade, weighing 12-14 g, and 28-30 days old, were purchased from Guangdong Medical Experimental Animal Center with license number SCXK (Guangdong) 2013-0002.

[0065] Rats and mice maintained feed: Guangdong Medical Experimental...

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Abstract

The invention relates to an application of an edible fungus extract in preparing a preparation for treating and / or preventing liver injury related diseases caused by a high fat diet, in particular toan application of a red mushroom extract in preparing a preparation for treating and / or preventing liver injury related diseases caused by a high fat diet. The preparation method is simple and feasible, and low in operation cost; and an extraction solvent in the preparation method can be recycled, the residual risk of an organic reagent is avoided, the natural quality of the red mushroom extractis ensured, and the red mushroom extract is environment-friendly, and the method belongs to a green manufacturing technology. According to the invention, the raw materials are completely extracted, the raw materials are fully utilized, and the utilization rate of the raw materials is high on the basis of ensuring the effect of the extract. The red mushroom extract shows obvious treatment and / orprevention effects on liver injury related diseases, for example, the red mushroom extract can effectively relieve the deterioration of inflammation and improve various physiological and pathologicalindexes related to immunity, can be used in various fields such as medicines, health care products and the like, and has great economic and social values.

Description

technical field [0001] The present invention relates to the use of an edible fungus extract in preparing a preparation for treating and / or preventing diseases related to liver damage caused by a high-fat diet, in particular to the use of a russula extract in the preparation of a preparation for treating and / or preventing liver damage caused by a high-fat diet. Use in the preparation of diseases. Background technique [0002] Gut microbiome is known as "the second genome of the human body" and is closely related to human health. There are more than 1,000 species of human intestinal microorganisms, among which Firmicutes and Bacteroidetes are the dominant flora, and the number of genes in the intestinal genome is more than 100 times that of the human genome. The intestinal flora and the host have a mutually beneficial symbiotic relationship, maintaining a dynamic balance in the intestinal tract. When the balance is broken, people may suffer from various diseases. Existing st...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P1/16A23L31/00A23L33/10
Inventor 陈地灵唐晓萃郭殷锐吴清平谢意珍帅欧杨柏华
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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