Unlock instant, AI-driven research and patent intelligence for your innovation.

Purine dione as wnt pathway modulator

A pathway and compound technology, applied in anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc.

Active Publication Date: 2019-05-21
AGENCY FOR SCI TECH & RES
View PDF12 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Wnt signaling is critical for stem cell maintenance, it may therefore be via a different or parallel signaling pathway to the β-catenin pathway

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Purine dione as wnt pathway modulator
  • Purine dione as wnt pathway modulator
  • Purine dione as wnt pathway modulator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0224] The following examples provide compounds according to the invention as well as a number of general synthetic schemes for their preparation. Each synthetic scheme has been illustrated with a specific example, and the examples that follow can be prepared by this same general method. Those skilled in the art will readily understand the changes required for the illustrated examples of each synthetic scheme to prepare other related compounds.

[0225] Amine Synthesis

[0226] Suzuki Method A: A stirred solution of aryl halide (1 equiv), boronic acid (1.5 equiv) and sodium carbonate (2 equiv) in toluene (0.08M) and water (0.32M) was charged with argon. Degas for 15 minutes. Tetrakis(triphenylphosphine)palladium(0) (0.05 equiv) was added to the reaction mixture and the reaction mixture was heated to reflux for 16 hours. After the starting material was consumed, the reaction mixture was concentrated and water was added to the reaction mixture and extracted with ethyl acetate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
specific rotationaaaaaaaaaa
Login to View More

Abstract

The invention relates to a purine dione as a WNT pathway modulator. The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be insertedhere] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

Description

[0001] This application is a divisional application of the application dated May 19, 2014, the application number is 201480041283.2, and the invention title is "purine diketone as a WNT pathway regulator". technical field [0002] The present invention relates to Wnt pathway modulators, methods for making them, and methods of using them. Background technique [0003] This application claims priority from application GB1309333.1 filed on May 23, 2013, the entire content of which application is hereby incorporated by cross-reference. [0004] Wnt proteins are secreted glycoproteins that act as growth factors that regulate various cellular functions, including proliferation, differentiation, death, migration, and polarity, by activating multiple intracellular signal transduction cascades that Including β-catenin-dependent pathways and β-catenin-independent pathways. There are 19 Wnt members that have been discovered in humans and mice, and they exhibit unique expression profil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D473/08A61K31/522A61P27/02A61P3/10A61P9/10A61P13/12A61P17/06A61P19/00A61P19/02A61P35/00A61P35/02
CPCA61K31/522A61K31/5377C07D473/08C07D473/06A61P1/00A61P1/16A61P1/18A61P11/00A61P13/08A61P13/10A61P13/12A61P15/00A61P17/00A61P17/06A61P19/00A61P19/02A61P19/08A61P27/02A61P29/00A61P3/00A61P35/00A61P35/02A61P43/00A61P5/14A61P9/00A61P9/10A61P3/10C07B2200/13
Inventor 何淑仪S·E·布兰卡德A·J·杜拉斯瓦米J·阿拉姆V·A·阿德苏尔
Owner AGENCY FOR SCI TECH & RES