Glucan for preventing and treating hypertension and orally-taken yeast cell wall extract

A technology of yeast cell wall and glucan, applied in the field of medicine and health care, to achieve the effect of repairing immunity

Inactive Publication Date: 2019-05-24
石雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] We found that by taking β-1,3 / 1,6-glucan with a specific branch structure every day, it can effectively improve the non-specific immunity of the human body, thereby slowing down or treating unidentified lesions, and fundamentally eliminating The inducement of high blood pressure, so as to prevent and treat hypertension. This kind of β-1,3 / 1,6-glucan with a specific branch structure also has the effect of preventing and treating hyperlipidemia. The method of treating hypertension and hyperlipidemia by dextran non-specifically improving immunity has not been reported yet

Method used

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  • Glucan for preventing and treating hypertension and orally-taken yeast cell wall extract
  • Glucan for preventing and treating hypertension and orally-taken yeast cell wall extract
  • Glucan for preventing and treating hypertension and orally-taken yeast cell wall extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A yeast cell wall extract, the preparation method of which is:

[0048] 1) Using a conventional method to break the yeast cell wall and remove the cell content to obtain the yeast cell wall;

[0049] 2) Add 2-5% sodium hydroxide solution to the yeast cell wall, disperse, react at a temperature range of 70-90°C for 45 minutes to 3 hours, and remove the supernatant after centrifugation;

[0050] 3) Repeat step 2) 3 to 5 times;

[0051] 4) Titrate the pH of the product in step 3) to a range of 4.0 to 5.0 with a strong acid, redisperse in a sodium hydroxide solution, react at 70° C. for 45 minutes, and centrifuge to obtain a solid component.

[0052] 5) Washing and purifying with distilled water, and drying to obtain yeast cell wall extract powder, the purity of dextran is 81.46% as detected by high performance liquid chromatography.

[0053] The obtained yeast cell wall extract is displayed by a 9500-fold electron microscope as shown in the figure figure 2 As shown, th...

Embodiment 2

[0056] A yeast cell wall extract, the preparation method of which is:

[0057] 1) Using a conventional method to break the yeast cell wall and remove the cell content to obtain the yeast cell wall;

[0058] 2) Add 2-5% sodium hydroxide solution to the yeast cell wall, disperse, react at a temperature range of 70-90°C for 45 minutes to 3 hours, and remove the supernatant after centrifugation;

[0059] 3) Repeat step 2) 5 to 10 times;

[0060] 4) Titrate the pH of the product in step 3) to a range of 4.0 to 5.0 with a strong acid, redisperse in a sodium hydroxide solution, react at 70° C. for 45 minutes, and centrifuge to obtain a solid component.

[0061]5) Washing and purifying with distilled water, and drying to obtain yeast cell wall extract powder, the purity of dextran is 93.54% as detected by high performance liquid chromatography.

[0062] The obtained yeast cell wall extract is displayed by a 9500-fold electron microscope as shown in the figure figure 2 As shown, th...

Embodiment 3

[0064] Purchase two commercially available β-1,3 / 1,6-glucans, and the β-1,3 / 1,6-glucans of Example 1 and Example 2 of the present invention, under a 9500X electron microscope Under the observation, the image results are as follows image 3 As shown, its function is shown in the following table:

[0065] Table 1 Dextran of the present invention and commercially available dextran molecular structure and hypertension therapeutic effect contrast

[0066]

[0067]

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Abstract

The invention relates to glucan for preventing and treating hypertension and orally-taken yeast cell wall extract. The component, for preventing and treating hypertension, of the glucan is a beta-1,3-1,6 glucan unit with a specific branch structure. The glucan is obtained by orally taking the yeast cell wall extract, the yeast cell wall extract contains 75-95% of beta-1,3-1,6 glucan, the branch chain of the glucan is of a long branch chain structure, the content of the branch-chain glucose accounts for 18% or above of the total quantity of the glucan, a person orally takes 0.005-0.05g / kg bodyweight of the yeast cell wall extract every day during hypertension prevention and treatment, the effect can be seen in one month, and the person needs to continuously take the yeast cell wall extractfor at least 6 months. The glucan has a definite and stable hypertension prevention and treatment effect, the orally-taken yeast cell wall extract can be absorbed by the intestinal tract to allow thehuman body to obtain the beta-1,3-1,6 glucan branch structure, in-vivo lesions which can be detected or cannot be detected can be treated in a broad spectrum manner, and an evident prevention and treatment effect is achieved.

Description

technical field [0001] The invention relates to the field of medicine and health care, in particular to a glucan with the effect of preventing and treating hypertension and a yeast cell wall extract for oral administration. The dextran and the yeast extract for oral administration can also be used for treating hyperlipidemia prevention. Background technique [0002] Dextran refers to a homopolysaccharide composed of glucose as a monosaccharide, and the glucose units are connected by glycosidic bonds. With the different types of microorganisms and growth conditions, their structures are also different. Among the glucans, β-glucan is the most physiologically active. The active structure of β-glucan is a polysaccharide composed of glucose units, most of which are combined by β-1,3, which is the way of glucose chain connection. It can activate macrophages and neutrophils, etc., so it can increase the content of leukin, cytokinin and special antibodies, and fully stimulate the ...

Claims

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Application Information

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IPC IPC(8): A61K31/716A61K36/064A61P9/12A61P3/06A61P37/04C08B37/02
Inventor 石雨
Owner 石雨
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