Application and preparation of systemic lupus erythematosus treating and rehabilitating substance

A technology for seeds and products, applied in the field of biomedicine, can solve problems such as long-term use

Inactive Publication Date: 2019-05-24
XISHUANGBANNA HUAKUN BIOTECH CO LTD
2 Cites 0 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0004] At present, patients with systemic lupus erythematosus are mainly treated with hormones...
View more

Abstract

The invention discloses a rubber tree seed fat-soluble component distilled product and application thereof. The rubber tree seed fat-soluble component distilled product can be applied to drugs, healthcare products and foods to treating and rehabilitating patients suffering from systemic lupus erythematosus. A preparation method of the rubber tree seed fat-soluble component distilled product comprises extracting the fat-soluble components of rubber tree seeds as the raw material, heating the raw material in vacuum, and inletting vapor for distillation; condensing gas molecules carried by the vapor, and collecting oily matters floating on the condensate water to obtain the rubber tree seed fat-soluble component distilled product. By daily orally taking or eating the drugs, the healthcare products and the foods which are added with the rubber tree seed fat-soluble component distilled product, the patients suffering from systemic lupus erythematosus can achieve good treating and rehabilitating effects.

Application Domain

Immunological disordersPlant ingredients

Technology Topic

DistillationDiscoid lupus erythematosus +6

Image

  • Application and preparation of systemic lupus erythematosus treating and rehabilitating substance

Examples

  • Experimental program(14)

Example Embodiment

[0025] Example 1
[0026] Using 100kg of fresh rubber tree seeds as raw materials, after drying and shelling, 40kg of seed kernels were prepared. The seed kernel material is heated to 80-100 ℃, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds. Extruding 15kg of liquid material is the resin-soluble part of the rubber resin seed of the present invention.
[0027] Using 10 kg of fat-soluble substances extracted from rubber tree seeds as raw materials, under vacuum conditions, the raw materials are heated and heated, and steam is introduced for distillation. The gaseous molecules carried by the water vapor are condensed, and the oil floating on the condensed water is the distillation product of the fat-soluble part of the rubber tree seeds. The distillation conditions are as follows: the absolute pressure of the vacuum degree is 0.3Pa; when the raw material is heated to 160°C, water vapor is introduced, and the temperature is stopped when the temperature is raised to 253°C, and the temperature is maintained until the end of the distillation, and finally 0.9kg of resin of rubber tree seeds is obtained. Distillation product of the soluble fraction.
[0028] The best natural animal model of human systemic lupus erythematosus, namely NZB×NZW F1 female mice, was used as the experimental object. NZB×NZW F1 mice are a cross between New Zealand black mice and New Zealand white mice. The mice developed symptoms similar to those of human SLE, including thymic tissue degeneration, thymic epithelial atrophy and immunodeficiency, lymphadenopathy and splenomegaly, elevated levels of autoantibodies, and elevated proteinuria with systemic edema , Mesangial proliferative glomerulonephritis caused by immune complex deposition and often accompanied by crescent formation, renal failure and so on. The pathological manifestations of female mice are more severe (similar to humans, human beings also have a higher incidence and more severe disease), and the average lifespan is only about 5-8 months, which is much lower than that of normal female mice. The effect of the substance of the present invention in preventing and treating systemic lupus erythematosus can be measured by the change in the lifespan of female NZB×NZW F1 mice.
[0029] The experiment selected 280 NZB×NZW F1 female mice, 35 in each group, divided into 8 groups, namely: i blank pair group, given normal feed; ii. The feed of the substance (the added amount of this substance in the feed is 2.5g/kg, the daily feed intake of mice is 1/5 of its body weight, and the daily intake of this substance by mice is 0.5g/kg, which is equivalent to 30 times the low dose of 16.7 mg/kg of the human body); iii. The high-dose group of the substance of the present invention was given a feed supplemented with a high-dose substance of the present invention (the added amount of the substance in the feed was 15 g/kg, and the mice daily The feed intake is 1/5 of its body weight, and the daily intake of this substance in mice is 3g/kg, which is equivalent to 30 times the high dose of 100mg/kg in humans); iv. A high-dose feed of substance A, which is the distillation product of the fat-soluble part of flaxseed, is added to the feed at 15 g/kg, and the daily feed intake of mice is 1/5 of their body weight. The daily intake of the substance is 3g/kg, which is equivalent to 30 times of the high dose of 100mg/kg in the human body; v. The high-dose substance B control group was given feed supplemented with high-dose substance B. Substance B is fat-soluble in perilla seeds. Part of the distillation product (perilla seed oil), the addition amount in the feed is 15g/kg, the daily feed intake of mice is 1/5 of its body weight, and the daily intake of this substance by mice is 3g/kg. kg, equivalent to 30 times the high dose of 100 mg/kg of human body; vi. high dose C substance control group, given feed supplemented with high dose C substance, C substance is the distillation product of the fat-soluble part of corn germ (corn germ oil), The added amount in the feed is 15g/kg, the daily feed intake of mice is 1/5 of its body weight, and the daily intake of this substance by mice is 3g/kg, which is equivalent to a high dose of 100mg/kg for humans. 30 times; vii. The high-dose substance D control group was given a feed supplemented with high-dose substance D. Substance D was the distillation product of the fat-soluble part of olive fruit (olive oil), and the added amount in the feed was 15g/kg. The daily feed intake of mice is 1/5 of their body weight, and the daily intake of this substance by mice is 3g/kg, which is equivalent to 30 times the high dose of 100mg/kg in humans; viii. The high-dose substance E control group, Feeds supplemented with high doses of substance E, which is the distillation of the fat-soluble part of pumpkin seeds
[0030] The product (pumpkin seed oil) is added in the feed at 15g/kg, the daily feed intake of mice is 1/5 of its body weight, and the daily intake of this substance by mice is 3g/kg, which is equivalent to 30 times the high dose of 100mg/kg in humans.
[0031] The samples of abnormal death and obvious outlier samples in the experiment were removed, and 30 valid data were obtained for each group. The final test results are shown in the appendix. figure 1.
[0032] The experimental results show that the systemic lupus erythematosus model mice ate the feed supplemented with the substance of the present invention, whether it is a high-dose group or a low-dose group, their lifespan can be prolonged relative to the blank control group, and the difference in statistics is extremely significant. (P<0.01); the prolongation of mouse lifespan was positively correlated with the added amount of the substance of the present invention, and there was a very significant difference between the two (P<0.01). Anatomical data on experimental mice showed that the substance of the present invention can significantly improve the invasion of various organs of the body in the active stage of lupus, and the damage to each organ of the mice in the substance group of the present invention was less than that of the blank control group.
[0033] The experimental results also showed that when the systemic lupus erythematosus model mice ate the feed added with the distillation products of the fat-soluble parts of other oils, the lifespan of the mice was not significantly different from that of the blank control group (P>0.05).

Example Embodiment

[0034] Example 2
[0035] Using 100kg of fresh rubber tree seeds as raw materials, after drying and shelling, 40kg of seed kernels were prepared. The seed kernel material is heated to 80-100° C., and then subjected to static extrusion with a pressure of 50 MPa, and 12 kg of liquid material is extruded, which is the resin-soluble part of the rubber resin seed of the present invention.
[0036]Using 10 kg of fat-soluble substances extracted from rubber tree seeds as raw materials, under vacuum conditions, the raw materials are heated and heated, and steam is introduced for distillation. The gaseous molecules carried by the water vapor are condensed, and the oil floating on the condensed water is the distillation product of the fat-soluble part of the rubber tree seeds. The distillation conditions are: the absolute pressure of the vacuum degree is 0.01Pa; when the raw material is heated to 160°C, water vapor is introduced, and the temperature is stopped when the temperature is raised to 250°C, and the temperature is maintained until the distillation ends, and finally 0.9kg of resin of rubber tree seeds is obtained. Distillation product of the soluble fraction.
[0037] A pair of identical twins with systemic lupus erythematosus, female, aged 30 years, developed almost simultaneously. After the onset of the disease, both of them started treatment with the same variety and dose of basic drugs. The basic drug is hormone combined with immunosuppressive drugs.
[0038] A (sister) starts from the first day of basic drug treatment, and additionally takes the medicines made of the substances disclosed in the present invention for the treatment and rehabilitation of patients with systemic lupus erythematosus, and the dosage is 1 g/day (for systemic lupus erythematosus patients). Substances for the Treatment and Rehabilitation of Lupus Patients). After 2 months, the dose of the basic drugs (hormones and immunosuppressants) of A was reduced by half, and the condition remained stable. After 4 months of treatment according to the halved basic drugs (hormones plus immunosuppressants) plus 1 gram/substance invented in Japan (6 months after the onset of treatment), patient A entered the recovery period, and the basic drugs (hormones and immunosuppressants) were stopped. Inhibitors), only take medicines made from the substances disclosed in the present invention for the treatment and rehabilitation of patients with systemic lupus erythematosus, and the dosage is still 1 g/day (calculated based on the substances for the treatment and rehabilitation of patients with systemic lupus erythematosus). ), the condition has remained stable and has not recurred.
[0039] B (sister) has been treated with basic medicines and has not taken any additional substances except normal diet. Two months later, B tried to reduce the dose of basic drugs (hormones and immunosuppressants), but the condition always recurred and the dose reduction failed. After 4 months of treatment with the initial dose of basic drugs (hormones plus immunosuppressants) (6 months after the onset of treatment), the patient entered the rehabilitation period. However, once the patient stops taking hormones and immunosuppressants, the disease will always recur, and finally, they can only take hormones and immunosuppressants for a long time.

Example Embodiment

[0040] Example 3
[0041] Using 100kg of fresh rubber tree seeds as raw materials, after drying and shelling, 40kg of seed kernels were prepared. The seed kernel material is heated to 80-100 ℃, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds. Extruding 15kg of liquid material is the resin-soluble part of the rubber resin seed of the present invention.
[0042] Using 10 kg of fat-soluble substances extracted from rubber tree seeds as raw materials, under vacuum conditions, the raw materials are heated and heated, and steam is introduced for distillation. The gaseous molecules carried by the water vapor are condensed, and the oil floating on the condensed water is the distillation product of the fat-soluble part of the rubber tree seeds. The distillation conditions are as follows: the absolute pressure of the vacuum degree is 0.3Pa; when the raw material is heated to 160°C, water vapor is introduced, and the temperature is stopped when the temperature is raised to 253°C, and the temperature is maintained until the end of the distillation, and finally 0.9kg of resin of rubber tree seeds is obtained. Distillation product of the soluble fraction.
[0043] A pair of identical twins with systemic lupus erythematosus, female, aged 27 years, developed almost simultaneously. After the onset of the disease, both of them were treated with the same dose of hormone plus immunosuppressive drug regimen.
[0044] A (sister), starting from the first day of basic drug treatment, additionally takes the health food made from the distillation product of the fat-soluble part of rubber tree seeds, which is a substance for the treatment and rehabilitation of patients with systemic lupus erythematosus disclosed in the present invention, and the dosage is It is 2 g/day (calculated as substances for the treatment and rehabilitation of patients with systemic lupus erythematosus). After 2 months, the dose of the basic drugs (hormones and immunosuppressants) of A was reduced by half, and the condition remained stable. After 4 months of treatment according to the halved basic drugs (hormones plus immunosuppressive agents) plus 2 grams/substances invented in Japan (6 months after the onset of treatment), patient A entered the recovery period, and the basic drugs (hormones and immunosuppressants) were stopped. Inhibitors), only take medicines made from the substances disclosed in the present invention for the treatment and rehabilitation of patients with systemic lupus erythematosus, and the dosage is still 10 grams per day (calculated based on the substances for treatment and rehabilitation of patients with systemic lupus erythematosus). ), the condition has remained stable and has not recurred.
[0045] B (Sister), starting from the first day of basic drug treatment, additionally consume food made from the distillation product of linseed oil, a fat-soluble substance extracted from flax seeds, in an amount of 2 g/day (to extract from flax seeds) the fat-soluble substance of the distillation product of linseed oil). Two months later, B tried to reduce the dose of basic drugs (hormones and immunosuppressants), but the condition always recurred and the dose reduction failed. Continue the treatment for 4 months after the initial dose of basic drugs (hormones plus immunosuppressants) and food made from the distillate of linseed oil, a fat-soluble substance extracted from flax seeds (6 months after the onset of treatment). ) The patient entered the recovery period. However, once the patient stops taking hormones and immunosuppressants, the disease will always recur, and finally, they can only take hormones and immunosuppressants for a long time.

PUM

no PUM

Description & Claims & Application Information

We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products