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Yak skin polypeptide with blood tonifying effect and preparation method thereof

A yak skin and skin peptide technology, which is applied in the fields of peptides, blood diseases, extracellular fluid diseases, etc., can solve the physical and chemical properties of yak skin glue - denaturation temperature, emulsification performance, foaming ability, foaming stability and anti-oxidation performance differences and other issues, to achieve the effect of increasing economic added value, simplifying the preparation and operation process, and avoiding waste

Inactive Publication Date: 2019-05-31
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previous research has found that yak hide glue with different molecular weights has great differences in physical and chemical properties - denaturation temperature, emulsification performance, foaming ability and foaming stability, anti-oxidation performance, etc.

Method used

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  • Yak skin polypeptide with blood tonifying effect and preparation method thereof
  • Yak skin polypeptide with blood tonifying effect and preparation method thereof
  • Yak skin polypeptide with blood tonifying effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A yak leather polypeptide with blood-enriching effect. The molecular weight is composed of 17KDa, 34 KDa, and 43 KDa. The maximum absorption wavelength of the peptide bond is at 216 nm. The infrared spectrum of the amide I band is at 1600~1700 cm. -1 Where the amide II band infrared spectrum is at 1560~1500 cm -1 Where the IR spectrum of Amide III is at 1234~1237 cm -1 Place.

[0027] A preparation method of yak skin polypeptide with blood-enriching effect, including the following steps:

[0028] (1) Microdermabrasion: Clean the Qinghai-Tibet Plateau yak skin after depilation and degreasing, cut it into 10cm squares with a trimmer, and place it in a microdermabrasion machine to remove the epidermis and clean it;

[0029] (2) Heating: Add the ground yak skin to a glycine buffer with a pH of 1 and a concentration of 0.1 mol / L in a ratio of 1:1, microwave heating for 2 min, and cooling to room temperature;

[0030] (3) Foam extraction: take pure water, heat it until the water boils...

Embodiment 2

[0036] A yak leather polypeptide with blood-enriching effect. The molecular weight is composed of 17KDa, 34 KDa, and 43 KDa. The maximum absorption wavelength of the peptide bond is at 216 nm. The infrared spectrum of the amide I band is at 1600~1700 cm. -1 Where the amide II band infrared spectrum is at 1560~1500 cm -1 Where the IR spectrum of Amide III is at 1234~1237 cm -1 Place.

[0037] A preparation method of yak skin polypeptide with blood-enriching effect, including the following steps:

[0038] (1) Microdermabrasion: Clean the Qinghai-Tibet Plateau yak skin after depilation and degreasing, cut it into 15cm squares with a cutter, and place it in a microdermabrasion machine to remove the epidermis and clean it;

[0039] (2) Heating: Add the ground yak skin into a glycine buffer with a pH of 9 and a concentration of 0.1 mol / L in a ratio of 1-10 at a ratio of 1 to 10, microwave heating for 30 min, and cooling to room temperature;

[0040] (3) Foam extraction: take pure water, heat...

Embodiment 3

[0046] A yak leather polypeptide with blood-enriching effect. The molecular weight is composed of 17KDa, 34 KDa, and 43 KDa. The maximum absorption wavelength of the peptide bond is at 216 nm. The infrared spectrum of the amide I band is at 1600~1700 cm. -1 Where the amide II band infrared spectrum is at 1560~1500 cm -1 Where the IR spectrum of Amide III is at 1234~1237 cm -1 Place.

[0047] A preparation method of yak skin polypeptide with blood-enriching effect, including the following steps:

[0048] (1) Microdermabrasion: Clean the Qinghai-Tibet Plateau yak skin after depilation and degreasing, cut it into 13cm squares with a trimmer, and grind the epidermis in a microdermabrasion machine to clean it;

[0049] (2) Heating: Add the ground yak skin to the glycine buffer with a pH of 4 and a concentration of 0.1 mol / L in a ratio of 1:5, microwave heating for 15 min, and cooling to room temperature;

[0050] (3) Foam extraction: take pure water, heat it until the water boils, and put i...

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Abstract

The invention relates to the field of medicines, in particular to a yak skin polypeptide with blood tonifying effect and a preparation method thereof.The molecular weight of the yak skin polypeptide is composed of 17KDa, 34KDa and 43KDa, the maximum ultraviolet absorption wavelength of peptide bonds is at 216nanometer, the amide I band infrared spectrum is at 1600 '-1700' cm <-1>, the amide II band infrared spectrum is at 1560 '-1500' cm <-1>, and the amide III infrared spectrum is at 1234 '-1237' cm <-1>.The preparation method comprises grinding skin, heating, extracting foam, preparing enzymolysis solution, centrifuging, concentrating, separating, and drying.According to the invention, the pure natural pollution-free Qinghai-Tibet plateau yak skin is used as a main raw material, the rawmaterial sources are wide, the nutrition is rich, the economic added value of the yak skin is improved; and meanwhile, a product with the effect of enriching blood is added; the preparation operationflow is simple, and the prior peeling machine is changed into a grinding machine, so that waste caused by different thickness of raw materials is avoided; and the prepared yak skin polypeptide has theblood-enriching bioactive components with three molecular weight sections.

Description

Technical field [0001] The invention relates to the field of medicines, in particular to a yak skin polypeptide with blood-enriching effect and a preparation method thereof. Background technique [0002] The yak is a cattle species endemic to the plateau. It lives in the harsh living environment of hypoxia, high cold, high altitude, low and sparse pasture, and long withered grass. The glue made from its fresh skin is rich in nutrients. According to literature, yak hide glue contains 20.95% of essential amino acids and mineral elements such as calcium, sodium, magnesium, and potassium. Preliminary research work found that yak hide rubber with different molecular weights has great differences in physical and chemical properties-denaturation temperature, emulsification performance, foaming ability and foaming stability, and oxidation resistance. Therefore, the development of yak leather products can not only improve the economic value of yak, but also has positive significance for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K2/00C12P21/06A61P7/06
Inventor 杜玉枝杨红霞肖远灿李岑毕宏涛张明魏立新
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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