Inhibitors of indoleamine 2,3-dioxygenase and methods of their use

A C1-C6, OC1-C6 technology, applied in the field of enzyme active compounds, can solve problems such as different functions
CN109843293AInactive Publication Date: 2019-06-04BRISTOL MYERS SQUIBB CO
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BRISTOL MYERS SQUIBB CO
Publication Date
2019-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3 -dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and / or inflammatory disorders utilizing the compounds of the invention.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Provisional Application No. 62 / 380,042, filed August 26, 2016, which is hereby incorporated by reference in its entirety. field of invention

[0003] The present invention generally relates to compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and the use of compounds of the present invention in the treatment of proliferative disorders such as cancer, viral infections and / or methods for autoimmune diseases. Background of the invention

[0004] Indoleamine 2,3-dioxygenase (IDO; also known as IDO1) is an IFN-γ target gene that plays a role in immune regulation. IDO is an oxidoreductase and is one of two enzymes that catalyze the first and rate-limiting step in the conversion of tryptophan to N-formyl-kynurenine. It exists as a 41 kD monomer found in several cell populations includ...

Claims

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