Tissue engineering urethra stent and preparation technology thereof

Abstract

The invention discloses a tissue engineering urethra stent and a preparation technology thereof, and relates to the technical field of high molecular materials. Specifically, through the preparation technology, a tissue engineering urethra stent which is suitable for different individuals can be prepared, and through the preparation technology, large-scale batch production can be facilitated. Secondly, the tissue engineering urethra stent prepared through the preparation technology has favorable biocompatibility, favorable biodegradability and favorable bio-mechanical properties; and through the microcosmic porous structure of the tissue engineering urethra stent, adhesion and proliferation of seed cells can be guaranteed, and the tissue engineering urethra stent can carry the seed cells of large enough quantity, is suitable for urethra damage of different forms, and is particularly suitable for repair of long-segment urethra damage.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a tissue engineering urethral support and a preparation process thereof. Background technique [0002] Urethral stenting has been greatly developed in recent years. At present, the commonly used clinical method is to place a tissue engineered urethral stent at the stricture of the urethra to expand the stricture or obstruction of the urethra. This stent is made of stainless steel, synthetic fiber silica gel or nickel-titanium alloy. It can be placed in the stricture of the urethra through the cystoscope to expand the narrow and closed posterior urethra. After recovery of voiding function. [0003] Urethral tissue damage and functional loss in children caused by factors such as trauma, tumor, and surgery are common diseases of the urinary system, and the search for ideal repair materials for urethral defects has always been the focus of research. [0004] Traditional ...

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Problems solved by technology

[0009] However, the main disadvantage of this type of material is that the protein content between batches of materials varies, and its network structure such as pore size and porosity cannot fully meet the needs of urethral reconstruction, and its pore size and porosity are extremely difficult to quantify Regulation, since such materials are mostly obtained from pigs, there are also ethical aspects and risks of disease transmission in their practicality

[0010] (2) Natural polymer materials: These materials are natural extracts such as silk fibroin and collagen, which have good cytocompatibility and are conducive to the adhesion, proliferation and differentiation of seed cells, but the biological properties of such materials The mechanical properties are poor, and it is difficult to shape, and there are large differences in the biochemical properties of each batch of products

The disadvantage is that these polymer materials are all hydrophobic polyester materials, which lack cell recognition signals and are not conducive to the adhesion of seed cells

[0012] Although the above two polymer scaffold materials can be used in the repair of short urethral defects, they have both confirmed the feasibility of reconstructing the urethra with tissue engineering materials, but they still cannot prove that they can repair and reconstruct long-term urethral defects without damage.

And this kind of tissue engineering tissue engineering urethral scaffolds all have the disadvantages of low utilization rate of seed cells and uneven distribution.

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