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A kind of production method of pharmaceutical intermediate hexahydropyrene

An intermediate and pharmaceutical technology, which is applied in the field of producing pharmaceutical intermediate hexahydropyrene by hydrogenation process, which can solve the problems affecting the operation cycle of the device and the coking of furnace tubes, etc.

Active Publication Date: 2022-03-08
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hexahydropyrene products cannot be extracted from the distillate, and only blended fuel oil is produced. The coal tar directly entering the high-temperature heating furnace in this process will cause coking of the furnace tube and affect the normal operation cycle of the device.

Method used

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  • A kind of production method of pharmaceutical intermediate hexahydropyrene
  • A kind of production method of pharmaceutical intermediate hexahydropyrene
  • A kind of production method of pharmaceutical intermediate hexahydropyrene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Such as figure 1 As shown in the flow process, the catalyst in the supplementary hydrofinishing reaction zone is not segmented, but only a kind of catalyst A is used, wherein the operating conditions of the supplementary hydrofinishing reaction zone and the yield and purity of the obtained hexadecahydropyrene are as shown in Table 5 Show.

Embodiment 2

[0078] Such as figure 1 As shown in the flow process, the catalyst in the supplementary hydrofinishing reaction zone is not segmented, but only a catalyst B is used, wherein the operating conditions of the supplementary hydrofinishing reaction zone and the yield and purity of the obtained hexadecahydropyrene are as shown in Table 5 Show.

Embodiment 3

[0082] Such as figure 1 In the process shown, the supplementary hydrofinishing reaction zone is divided into two supplementary hydrofinishing reaction stages, and the gradation scheme of catalyst A and catalyst B is adopted. Catalyst A is used in the first supplementary hydrofinishing reaction stage, and catalyst A is used in the second supplementary hydrofinishing reaction stage. Catalyst B was used in the reaction stage, wherein, the operating conditions of the supplementary hydrotreating reaction zone and the yield and purity of the obtained hexadecahydropyrene are shown in Table 5.

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Abstract

The invention discloses a production method of a pharmaceutical intermediate hexahydropyrene. After the coal tar raw material is pretreated, it undergoes hydrofining and hydrocracking reactions, and the resulting liquid is subjected to fractional distillation; the obtained diesel fraction enters the supplementary refining reaction zone, and undergoes hydrogenation saturation reaction under the action of supplementary refining catalyst; the supplementary refined product is cut , the resulting fractions were cooled and filtered to obtain high-purity hexadecahydropyrene. The present invention realizes for the first time the purpose of producing hexahydropyrene by using coal tar raw material through a hydrogenation process. Compared with the prior art, the method of the present invention obtains high-purity hexadecahydropyrene, and at the same time produces clean fuel oil and solvent oil products whose quality meets the requirements. The method of the invention changes the situation that hexadecahydropyrene is completely dependent on imports, improves the economical efficiency of coal tar processing, and has the characteristics of simple process and low energy consumption for operation.

Description

technical field [0001] The invention relates to a production method of a pharmaceutical intermediate hexahydropyrene, specifically, a method for producing a pharmaceutical intermediate hexahydropyrene by a hydrogenation process. Background technique [0002] The production process of high-purity hexadecahydropyrene is harsh and expensive. Therefore, high-purity hexadecahydropyrene products that meet market requirements have become rare resources. [0003] At present, the synthesis method is one of the important ways to produce high-purity hexadecahydropyrene. Pyrene is an important component in coal tar, which is enriched in the fraction at 300-360 °C during the initial distillation of coal tar, and can be obtained through traditional rectification and crystallization methods. The raw material of coal tar basically does not contain hexadecahydropyrene, and the direct extraction of hexadecahydropyrene from coal tar has not been reported. The operation cost is high, and the e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C4/18C07C5/10C07C7/00C07C7/04C07C7/163C10G67/02C07C13/66
Inventor 孙国权姚春雷全辉张志银方向晨樊宏飞
Owner CHINA PETROLEUM & CHEM CORP