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A dinuclear cd(ii) complex containing sulfur-sulfur bond and its in-situ synthesis method

A technology of in situ synthesis and complexes, applied in cadmium organic compounds, drug combinations, antineoplastic drugs, etc.

Inactive Publication Date: 2021-05-14
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are many literature reports on in situ reactions, no 3,3'-bis(5-mercapto-1,2,4-triazole) is oxidized to form a trimeric direct reaction containing sulfur-sulfur bonds. Chain Ligands and Formation of Binuclear Cd(Ⅱ) Complexes Report

Method used

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  • A dinuclear cd(ii) complex containing sulfur-sulfur bond and its in-situ synthesis method

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Embodiment

[0017] A method for in-situ synthesis of a dinuclear Cd(II) complex containing a sulfur-sulfur bond, comprising the steps of:

[0018] (1) Weigh 0.0400g 3,3’-bis(5-mercapto-1,2,4-triazole) (H 4 L) and 0.0617g cadmium nitrate hexahydrate Cd(NO 3 ) 2 ·6H 2 O, mixed in 10mL dimethylformamide (DMF), stirred at room temperature for 30 min;

[0019] (2) Transfer the above mixture into a 25 mL hydrothermal reaction kettle with a polytetrafluoroethylene liner, place it in a constant temperature oven at 160ºC, cool it down to room temperature after 3 days, and filter;

[0020] (3) The above filtrate was placed in a beaker and volatilized naturally at room temperature to obtain single crystal grade colorless needle crystals.

[0021] see figure 1 , Example Schematic diagram of the molecular structure of a dinuclear Cd(II) complex containing a sulfur-sulfur bond. For the convenience of observation, the solvent water molecules in the crystal are deleted. It can be seen from the str...

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Abstract

The invention discloses a dinuclear Cd(II) complex containing sulfur-sulfur bonds and an in-situ synthesis method thereof. The chemical formula of the dinuclear Cd(II) complex is: [Cd 2 (H 6 L 1 ) 2 ]·4H 2 O, where H 8 L 1 It is a chain trimer formed by three 3,3'-bis(5-mercapto-1,2,4-triazole) connected by two pairs of sulfur-sulfur bonds. The in-situ synthesis method of the complex comprises the following steps: (1) Weighing 0.04-0.05g 3,3'-bis(5-mercapto-1,2,4-triazole) and 0.06-0.07g hexahydrate Cadmium nitrate, mixed in 9‑11mL dimethylformamide, stirred at room temperature for 25‑35 min; (2) Transfer the above mixed solution into a 25mL hydrothermal reaction kettle with a polytetrafluoroethylene liner, and place In a constant temperature oven at 150‑170ºC, cool down to room temperature after 3‑4 days, and filter; (3) Put the above filtrate in a beaker and volatilize naturally at room temperature to obtain single crystal grade colorless needle crystals. The complex of the present invention has potential application value in the aspects of antibacterial, antitumor and as a carrier for drug targeted release.

Description

technical field [0001] The invention relates to a cadmium complex, in particular to a dinuclear Cd(II) complex containing a sulfur-sulfur bond and an in-situ synthesis method thereof. Background technique [0002] In situ reaction is one of the hotspots in coordination chemistry research. Although there are many literature reports on in situ reactions, no 3,3'-bis(5-mercapto-1,2,4-triazole) is oxidized to form a trimeric direct reaction containing sulfur-sulfur bonds. Chain ligands, and then a report on the formation of dinuclear Cd(II) complexes. [0003] Sulfur-containing triazoles are widely used as intermediates in medicine, pesticides and other fields, and their complexes with metal ions also have good antibacterial and anticancer activities. When a compound containing a sulfur-sulfur bond reaches a tumor cell, a sulfur-sulfur bond breaking reaction will occur due to glutathione present in a large amount in the cell, therefore, by 3,3'-bis(5-mercapto-1 , 2,4-triazole...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F3/08A61P35/00A61P31/02A61P31/04
Inventor 蒋毅民王慧许小陵
Owner GUANGXI NORMAL UNIV