Tumor immune biomarker and application thereof
A biomarker and tumor technology, applied in the field of biomedicine, can solve the problem that the function of liver cancer immune markers has not been reported, and achieve the effects of improving the early diagnosis rate, the response rate and the clinical prognosis.
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[0032] Specific embodiment one: A tumor immune biomarker of this embodiment, the marker is PGLYRP2 gene or its expressed protein; the PGLYRP2 gene includes PGLYRP2 isoform 1 gene and PGLYRP2 isoform 2 gene ; Its expressed proteins include PGLYRP2 isoform 1 protein and PGLYRP2 isoform 2 protein;
[0033] The nucleotide sequence of the PGLYRP2 isoform 1 gene is shown in the sequence table Seq ID No:1;
[0034] The nucleotide sequence of the PGLYRP2 isoform 2 gene is shown in the sequence table Seq ID No: 3;
[0035] The amino acid of PGLYRP2 isoform 1 protein is shown in the sequence table Seq ID No: 2;
[0036] The amino acid of PGLYRP2 isoform 2 protein is shown in the sequence table Seq ID No: 4.
[0037] PGLYRP2 isoform 1 mRNA of this embodiment (NCBI reference sequence: NM_052890.4).
[0038] PGLYRP2 isoform 2 mRNA of this embodiment (NCBI reference sequence: NM_001363546.1).
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[0039] Embodiment 2: The application of a tumor immune biomarker of this embodiment is used to prepare a preparation for diagnosis, prediction, detection or screening of liver cancer, and for predicting whether liver cancer tumor immunotherapy is effective.
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[0040] Embodiment 3: The application of a tumor immune biomarker of this embodiment is used to prepare a kit for diagnosing, predicting, detecting, or screening liver cancer, and predicting whether liver cancer tumor immunotherapy is effective.
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