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Tumor immune biomarker and application thereof

A biomarker and tumor technology, applied in the field of biomedicine, can solve the problem that the function of liver cancer immune markers has not been reported, and achieve the effects of improving the early diagnosis rate, the response rate and the clinical prognosis.

Pending Publication Date: 2019-06-14
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the function of PGLYRP2 at home and abroad mainly focuses on the innate immune signaling pathway, and there is no report on its role in liver cancer and its function as an immune marker of liver cancer

Method used

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  • Tumor immune biomarker and application thereof
  • Tumor immune biomarker and application thereof
  • Tumor immune biomarker and application thereof

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0032] Embodiment 1: A tumor immune biomarker according to this embodiment, the marker is the PGLYRP2 gene or its expressed protein; the PGLYRP2 gene includes the PGLYRP2 isoform 1 gene and the PGLYRP2 isoform 2 gene ; The expressed protein includes PGLYRP2 isoform 1 protein and PGLYRP2 isoform 2 protein;

[0033] The nucleotide sequence of the PGLYRP2 isoform 1 gene is shown in the sequence table Seq ID No: 1;

[0034] The nucleotide sequence of the PGLYRP2 isoform 2 gene is shown in the sequence table Seq ID No: 3;

[0035] The amino acid of PGLYRP2 isoform 1 protein is shown in the sequence table Seq ID No: 2;

[0036] The amino acid of PGLYRP2 isoform 2 protein is shown in Seq ID No: 4 in the sequence table.

[0037] PGLYRP2 isoform 1 mRNA of this embodiment (NCBI reference sequence: NM_052890.4).

[0038] PGLYRP2 isoform 2 mRNA of this embodiment (NCBI reference sequence: NM_001363546.1).

specific Embodiment approach 2

[0039] Embodiment 2: The application of a tumor immune biomarker of this embodiment, which is used to prepare a preparation for diagnosing, predicting, detecting or screening liver cancer, and predicting whether the tumor immunotherapy for liver cancer is effective.

specific Embodiment approach 3

[0040] Embodiment 3: The application of a tumor immune biomarker of this embodiment, which is used to prepare a kit for diagnosing, predicting, detecting or screening liver cancer, and predicting whether the tumor immunotherapy for liver cancer is effective.

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Abstract

The invention discloses a tumor immune biomarker and application thereof, relates to the technical field of biological medicine, in particular to a liver cancer tumor immune biomarker and applicationthereof. The liver cancer tumor marker comprises PGLYRP2. The invention particularly relates to application of a PGLYRP2 gene and PGLYRP2 protein in diagnosis and treatment of hepatocellular carcinoma. A new marker is provided for early diagnosis, prognosis judgment and treatment scheme selection of liver cancer by researching the relationship between expression of the PGLYRP2 gene in liver cancertissue and clinical prognosis of liver cancer patients, immune cell infiltration of tumors and induction of host anti-tumor immune response so as to improve early diagnosis rate of liver cancer patients, improve response rate of liver cancer tumor immunotherapy and improve clinical prognosis. The invention is applied to the field of oncotherapy.

Description

technical field [0001] The invention relates to the technical field of biomedicine. Background technique [0002] Traditional tumor therapy (surgery, radiotherapy and chemotherapy) generally has a poor prognosis for patients with advanced liver cancer. At present, tumor immunotherapy has been approved for the treatment of various human cancers, and this therapy has achieved excellent results in some patients with advanced tumors. Effect. The global market for tumor immunotherapy drugs is also growing explosively. Although clinical studies have shown that a variety of tumor immunotherapy drugs have great potential, the overall response to immunotherapy in cancer patients is still low. Therefore, predicting and screening which tumor patients are suitable for immunotherapy by tumor immune biomarkers is of great significance to the success of tumor immunotherapy. [0003] Liver cancer is one of the common malignant tumors in my country, and its incidence rate ranks first in t...

Claims

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Application Information

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IPC IPC(8): C07K14/705C12N15/12G01N33/574C12Q1/6886
Inventor 史明陈曦冯佳肖力
Owner HARBIN INST OF TECH
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